Articles By Jack Cush, MD
Long-Term Safety of Adalimumab Reviewed
Burmester and colleagues have published their review of the long-term outcomes and safety issues with the TNF inhibitor, adalimumab (ADA). The analysis included 15,132 patients exposed to adalimumab in global RA clinical trials.
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Pravastatin Improves Obstetric Outcomes in Anti-Phospholipid Syndrome Patients
Pregnancy complications of anti-phospholipid syndrome (APS) have included recurrent abortions, spontaneous fetal loss, preeclampsia, and premature birth. The etiopathogenesis of these events has been presumed to be placental thrombosis or infarction.
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Novel Rise of Combined Dermatology-Rheumatology Clinics
Rheumatology News has a novel online report about combined rheumatology-dermatology clinics. In the last several years, there have been a few of these in operation (Boston, Chicago, Rhode Island).
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MONEYBALL
The movie Moneyball is a David versus Goliath tale with the A’s (David) struggling to compete with Goliath teams like the Yankees. The movie pits hunch-driven “expertise” (convention) against a mathematic approach to decision making (Moneyball). Would you trust a big Whopper computer printout of next best drug(s) to give to Mrs. Hawking who has psoriatic arthritis and needs to start a DMARD? I believe most of you would huff and scoff at a formulaic or number-driven approach.
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RheumNow Week in Review – 22 July 2016
From tofacitinib developmental trials in RA and psoriasis and adherence to T2T in early RA to a rheumatology pearl about dapsone and much more, here are the highlights of what you may have missed on RheumNow.com this week.
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Epigenetic Changes to Inflammasome Found in Autoinflammatory Syndromes
The gene mutations underlying inflammasome activity have been well described, but there appears to be variable penetrance among patients with the same gene mutation, suggesting additional mechanisms may influence disease expression.
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Little Evidence Favoring the Health Benefits of Vitamin D
Vitamin D certainly plays a pivotal role in bone health and immune function.
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DEXA Still Needed While on Bisphosphonates
Reuters reports that a study of 6629 Canadian women with osteoporosis taking bisphosphonates found that nearly one in five had a decrease in bone density while on medication. (Citation source: http://buff.ly/2afb7nj)
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Knee Replacement and the Physical Terrorist
Experience is a great teacher. My experience with knee replacement surgery taught me the pivotal importance of the physical therapist in individual outcomes.
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Prevalence of Spondyloarthropathy in Fibromyalgia
With the introduction of ASAS criteria for the diagnosis of axial and peripheral spondyloarthropathy, there has been a debate about whether patients with fibromyalgia (FM) could be mistaken for a spondyloarthropathy, or vice versa.
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