B cell Targeting in SLE
MedPage Today
Recent News
Read ArticleKey Takeaways
- Many autoimmune diseases are driven by abnormal B cells, which can produce anti-self antibodies and also dysregulate other immune system components.
- Earlier reports have indicated that the oncology drug teclistamab (Tecvayli), which targets B-cell maturation antigen (BCMA) and the CD3 protein, was helpful in a small
2-Gene Blood Test for Kawasaki Disease in Febrile Children
JAMA Network Open has publshed that a simple 2-gene blood test may aid the earlier diagnosis of Kawasaki disease in children with febrile illnesses.
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Can AI Predict Progression to RA?
Dr. Jonathan Kay reports on abstract POS0967 at EULAR 2026 in London
https://t.co/m8wvp93mTA https://t.co/ADZa9C4068
Dr. John Cush @RheumNow ( View Tweet)
No Fetal Risks with First Trimester NSAID Use
PLoS Medicine has published a population-based retrospective cohort study from the Southern Israeli Pregnancy Registry (siPREG) project showing that 1st trimester exposure to NSAIDs was not associated with major congenital malformatoin (MCM) risk.
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Where are we with Biomarkers in Rheumatoid Arthritis?
Biomarker interest has grown considerably in the last 2 decades, owing to advances in genetics, imaging, protein, and multiomics. Despite these advances, biomarkers as the predictive holy grail of RA therapeutics and prognostication have not yet advanced beyond rheumatoid serologies and C-reactive protein (CRP).
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Do You Zoster Vaccinate? (6.19.2026)
Dr. Jack Cush reviews the news, journal reports and best ways to review EULAR 2026.
https://t.co/hOfXR39s3H https://t.co/X7skwKrCc3
Dr. John Cush @RheumNow ( View Tweet)
Missed a session at EULAR 2026?
No problem.
The RheumNow Faculty Reporter team was on the ground covering the studies, debates, and breakthroughs that are shaping the future of rheumatology. From JAK safety and CAR-T therapies to advances in lupus, psoriatic arthritis, and ILD, https://t.co/YZ7oRNXfqU
Dr. John Cush @RheumNow ( View Tweet)
Type 2 diabetes pts taking semaglutide have a 15% lower risk of fractures. Endocrine society abstract EHR study of 26K SEM vs controls. Previous studies have linked rapid weight loss to a greater risk of fractures https://t.co/7nRYST5fPX https://t.co/kJ9Y5gcXFD https://t.co/AD6iVfkK3w
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Dr. John Cush @RheumNow ( View Tweet)
Prospective study of 6 newly Dx RA pts starting MTX shows MTX causes a decline in T follicular helper (Tfh) cells and plasmablasts (@ wk 3 before clin response), selectively in responders but not nonresponders. MTX shifts cellular & gene expression towards a more physiological https://t.co/Q1M4vgN0aD
Dr. John Cush @RheumNow ( View Tweet)
#TB Infection or reactivation is Psoriasis or Psoriatic Arthritis pts taking IL-23 inhibitors is rare, rare. Literature review showed 34 studies of IL-23i in PsO had no new TB, but 1 case of LTBI reactivation. In 8 IL-23i PsA studies there were NO new TB or LTBI reactivations https://t.co/NFIap7DSOr
Dr. John Cush @RheumNow ( View Tweet)
Systematic review of live virus MMR in #JIA had 9 studies (743 pts) showing no flares, good safety & immunogenicity in short term, BUT incomplete or less durable protection in biologic-treated patients, especially for measles & rubella. 5-yrs post MMR, seroprotection was lower if https://t.co/JQhL9o1O4e
Dr. John Cush @RheumNow ( View Tweet)
Redefining axial spondyloarthritis
An editorial in Lancet Rheumatology calls for "..reframing axSpA as a systemic, autoimmune inflammatory disease with multiorgan involvement and substantial unmet need."
The pathogenesis relies on not only HLA-B27, but also on environmental triggers, immune dysregulation, and gut inflammation. AxSpA is not confined to the spine, as gut dysbiosis leads to immune activation, driven by IL-17, IL-22, and TNF.
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JAMA Review on Low Back Pain
A comprehensive JAMA review synthesizes current evidence on the epidemiology, pathophysiology, clinical evaluation, and treatment of nonspecific low back pain, drawing on 108 publications identified from a PubMed search (2005–2026) and the most recent guidelines from the WHO, ACP, and NICE. While the primary audience is generalists, the review carries important implications for rheumatologists who regularly encounter patients with back pain
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EULAR 2026: Updated Recommendations for Vaccination in Patients with Autoimmune Inflammatory Rheumatic Diseases
The 2026 EULAR vaccination recommendations, presented by Victoria Furer, were developed by a multinational 25-member task force that include rheumatologists, an https://t.co/AFnsmEYj41
Dr. John Cush @RheumNow ( View Tweet)
Is there a path to precision medicine in #RA? Theres a substantial unmet need. Immunoengineering is possible thru nanotechnological delivery vectors, cellular therapeutics, & biomaterial scaffolds, with compelling preclinical and early clinical support. https://t.co/gL56EOlt7p https://t.co/IFSHOM8g7w
Dr. John Cush @RheumNow ( View Tweet)
Breckenridge Pharmaceutical received FDA approval for their generic version of tofacitinib on 6/4/26. 5 mg and 10 mg tablets are now available in the U.S. market, for both adult and pediatric use. Tofacitinib Tablets are manufactured in Martorelles, Spain. https://t.co/oAh0KQSFgs https://t.co/fNxEm31MAI
Dr. John Cush @RheumNow ( View Tweet)
This is a great WISE read for yound doctors - from the great WISE Dr. Adam Cifu -- Advice for Internship https://t.co/BUtXzJxQxQ
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Dr. John Cush @RheumNow ( View Tweet)
"When you make the choice to avoid becoming the most experienced person in a room (whatever room you’re in), you’re making a bet about the future. " - Seth Godin https://t.co/oWtDNWeoND https://t.co/2dpiFRGaxZ
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Dr. John Cush @RheumNow ( View Tweet)
From Cytokine Endotypes to Clinical Reality in Still’s Disease
Recent EULAR 2026 data highlight a paradigm shift in Still’s disease from syndromic management to biologically informed precision therapy.
https://t.co/fBtkDLPJNE https://t.co/y8NBW6VHHa
Dr. John Cush @RheumNow ( View Tweet)
Genicular artery embolization (GAE) in knee OA? Multiple open label studies & metanalyses suggest a clear pain benefit; BUT 3 sham-controlled RCTs have not demonstrated a statistically significant benefit over placebo. GAE is not addressed by ACR or EULAR guidelines. https://t.co/amIN6kzY74
Dr. John Cush @RheumNow ( View Tweet)
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From the Blog
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Do You Zoster Vaccinate? (6.19.2026)
RheumNow EULAR 2026 Rheumatology Round Up
EULAR 2026 RA Topic Panel
CAR-T Topic Panel EULAR 2026
Therapeutic Updates
Psoriatic arthritis and overweight or obesity
Sponsored by Lilly Medical Affairs
Dr. Merola presenting the results from TOGETHER‑PsA, a phase 3b trial evaluating the concomitant use of an IL‑17A antagonist and an incretin receptor agonist in adults with psoriatic arthritis and overweight or obesity.
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Poster Hall
Sponsored by AbbVie Medical Affairs + Health Impact
