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Malar,rash,SLE, Lupus

Low Dose IL-2 Therapy in SLE

Jack Cush, MD
Aug 17, 2022

A multicentre, proof-of-concept trial of suggests that low-dose IL-2 therapy may be effective in moderate-to-severe systemic lupus erythematosus (SLE).

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SCLE,DIL,PPI

Drug-Induced Lupus from Proton Pump Inhibitors

Jack Cush, MD
Aug 17, 2022

A wide range of therapies have been implicated in causing drug-induced lupus erythematosus (DIL); now it appears that proton pump inhibitors (PPIs) can be added to the list of causative drugs.

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Rheums! Do you have a rheumatology question or case for Jack Cush? Record it here and we may feature it on an upcoming podcast. Tell us your name and where you practice rheumatology. https://t.co/cvmbzknQqA https://t.co/6mX5eRUNuU

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Dr. John Cush RheumNow ( View Tweet)
Aug 17, 2022
Survey of 3357 retired Olympians (45 yrs) shows same OA rates as 1735 gen population (41yrs) - #OA in 23% (knee 7.4%, hip, ankle). OA from Injury, age, obesity. Prior knee/hip injury increased OA rates significantly (aOR 1.51/4.03) https://t.co/yZAHA8MYly https://t.co/W1StoLYjkl

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Dr. John Cush RheumNow ( View Tweet)
Aug 17, 2022
NEJM Clinical Images: 74-yoF with psoriatic arthritis has swelling of the fifth finger; found to have nontender, subcutaneous nodules in the hypothenar region and over the fifth finger. https://t.co/leVXN4WNXx https://t.co/5S5nD8ZgcQ

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Dr. John Cush RheumNow ( View Tweet)
Aug 17, 2022
Study of 209 Early RA (<1yr) pts found 23 (11%) with Drug Free Remission (DFR) after 74 mos of F/U; DFR maintained x 48 mo (18–82). DFR was assoc w/ early persistence on Therapy (HR 3.84). Adhering to prescribed treatment may lead to DFR https://t.co/oO8wKOKfxE https://t.co/DPX9JudplX

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Dr. John Cush RheumNow ( View Tweet)
Aug 17, 2022
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Favorable Pregnancy Outcomes in Spondyloarthritis

Jack Cush, MD
Aug 16, 2022

Pregnancy often occurs in women with axial spondyloarthritis (axSpA), and a recent cohort study suggests outcomes are generally better than what had been reported in the literature.

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JUNIPERA Study - Secukinumab in Juvenile PsA & ERA

Jack Cush, MD
Aug 16, 2022

JUNIPERA study evaluated secukinumab (SEC) in children with enthesitis-related arthritis (ERA) and juvenile psoriatic arthritis (JPsA) and was found to be safe and effective in patients with active ERA and JPsA who previous failed to respond to conventional therapy.

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Popeye sign (=biceps tendon rupture) #MedTwitter https://t.co/vES4juLCUp
Avraham Z. Cooper, MD AvrahamCooperMD ( View Tweet)
Aug 16, 2022
Exciting news to announce! Our book "Telerheumatology: Origins, Current Practice, and Future Directions" is now available for download and has been published on SpringerLink. #telerheumatology #rheumtwitter #rheum https://t.co/rW0g6WByTp

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Christine Peoples CPeoplesMD ( View Tweet)

Aug 16, 2022
Mass Gen Brigham study of Rheum (SARD) pts COVID severity over time (3/20-1/22) shows less severe COVID over time. 1449 SARD pts had COVID-19 (1/3 RA); 28% severe. Early COVID was more severe (46%) vs 15% w/ Omicron. Unvax were more severe (78% v 60%) https://t.co/DTge2od82Q https://t.co/LXeujT6zd5

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Dr. John Cush RheumNow ( View Tweet)
Aug 16, 2022
Has insurance moved to a new tactic to intimidate doctors from appeals? I was expecting to do a peer to peer to get #Xeljanz approved, they put me on the phone with a courtroom judge to make me swear I am telling the truth about why the medicine is needed for the patient.

TheDaoIndex KDAO2011 ( View Tweet)

Aug 16, 2022
Biosimilar switching is due to costs, formulary, relocation. Study of 23 studies, 3657 pts found only observational data, no RCTs. Ref product to biosimilar usually RCTs; Biosimilar switches usually real world evidence w/ good efficacy & no new risks. https://t.co/odAYHdbVd1 https://t.co/BabkVYsMBL

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Dr. John Cush RheumNow ( View Tweet)
Aug 16, 2022
Are you a fan of the RheumNow podcast? Please rate, like and review us wherever you get your podcast. We'd appreciate it!

Dr. John Cush RheumNow ( View Tweet)

Aug 16, 2022
Recurrence of axSpA in 1st-degree relatives (FDR) probands w/ 35-yrs F/U. From 363 AS probands & 806 FDR, 27.1% of B27(+) FDR developed axSpA; 18.2% from AS probands; 4% from nr-axSpA probands. Recurrence higher with B27+ probands https://t.co/1xczXdtrH3 https://t.co/mXZ72nVAqp

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Dr. John Cush RheumNow ( View Tweet)
Aug 16, 2022
UK Women’s Cohort -diet & Hip Fx risk study shows that amongst 26,318 women, 822 hip Fxs - Hip Fx risk was higher in Vegetarians (HR 1.33; 1.03, 1.71)) but not meat-eaters (HR 1.00; 0.85, 1.18) or pescatarians (0.97; 0.75, 1.26); unaffected by BMI https://t.co/tipy0IBp4D https://t.co/sG0lJAUgDj

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Dr. John Cush RheumNow ( View Tweet)
Aug 16, 2022
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Black Adults Have a Higher Gout Risk

Jack Cush, MD
Aug 15, 2022

In a cross-sectional study of US adults, gout was more prevalent in black adults compared to white adults; possibly explained by sex-specific dietary differences and social determinants of health and clinical factors. 

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Cochrane review of Stem cell transplantation in systemic sclerosis (3RCTs w/ 125 pts). Non‐myeloablative & myeloablative selective HSCT had moderate evidence for improved survival, skin thickness & function. But these had high Serious AE rates. https://t.co/d3CPsKiR88 https://t.co/QgCYBikhyl

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Dr. John Cush RheumNow ( View Tweet)
Aug 15, 2022
Urine-soluble CD163 as a biomarker in #SLE: usCD163 significantly higher w/ active lupus nephritis & correlates w/ UPCR, disease activity, anti-dsDNA Ab levels and a higher chronic kidney disease stage. https://t.co/Mxe53pCnEF https://t.co/BOspodqpSE

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Dr. John Cush RheumNow ( View Tweet)
Aug 15, 2022
Axial PsA frequency? Study of Derm identified PSO adults w/ chronic LBP, onset <45 yrs, not Rx w/ DMARDs--> 100 pts referred to Rheumatology; 14 pts dx w/ axPsA, 5 w/ peripheral PsA, & 3 w/ both axial & peripheral PsA https://t.co/oVxDcY17ZQ https://t.co/oIOfptskf3

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Dr. John Cush RheumNow ( View Tweet)
Aug 15, 2022

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