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A Tribute to Daniel L. Kastner, MD, PhD (1951–2026)
The rheumatology, genetics and NIH communities mourn for Dr. Daniel L. Kastner, who died on July 28, 2026, in Bethesda, Maryland, at age 74. The following are declarations, tributes, and memories dedicated to this mensch of a man, titan of science, memorable mentor and humble physician.
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Methotrexate Safety Tips (7.31.2026)
Dr. Jack Cush reviews the news and journal articles from this past week on RheumNow.com.
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Four Decades of Gout Management
During this month-long campaign on Gout, we have documented many significant changes in our approach to gout, as well as many unmet needs and deficiencies that merit our continued, primary attention. We are all familiar with the famous 1905 quote, “Those who cannot remember the past are
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Treatment goals in gout: aim for remission!
Rheumatologists are used to the concept of disease remission as this is a treatment goal we use for many chronic rheumatic diseases in our clinical practice.
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Tips for safe use of allopurinol
These are tips and hopefully the patients are abstaining from moderate alcohol and are not tipsy! Here are 5 tips that may not be totally obvious.
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Four Decades of Gout Management
During this month-long campaign on Gout, we have documented many significant changes in our approach to gout, as well as many unmet needs and deficiencies that merit our continued primary attention.
https://t.co/ddzj3RktDD https://t.co/x7o0HfWqHa
Dr. John Cush RheumNow ( View Tweet)
New, Advanced Therapies in Gout
New, Advanced Therapies in Gout explores the rapidly evolving therapeutic landscape beyond conventional urate-lowering therapy.
https://t.co/0uNK0nOEp6 https://t.co/YD7tQu2QrT
Dr. John Cush RheumNow ( View Tweet)
QD Clinic: Addressing Severe Gout Flares
Dr. Eric Dein, Summit, NJ, discusses a difficult-to-treat case of gout.
https://t.co/tochY0BUBj https://t.co/9hQ13cDY9s
Dr. John Cush RheumNow ( View Tweet)
Gout & Metabolic Syndrome
Dr. John Fitzgerald, Los Angeles, hates the expression "It's only Gout."
https://t.co/0JipL3kgcM https://t.co/jszxYAfZwa
Dr. John Cush RheumNow ( View Tweet)
Treatment goals in gout: aim for remission!
Rheumatologists are used to the concept of disease remission as this is a treatment goal we use for many chronic rheumatic diseases in our clinical practice. Recently, G-CAN (the Gout and Crystal Arthritis Network), endorsed a https://t.co/PP2NBqvo7E
Dr. John Cush RheumNow ( View Tweet)
Tips for safe use of allopurinol
https://t.co/Yn1u1bEj4F https://t.co/lMWPI9OsVe
Dr. John Cush RheumNow ( View Tweet)
Gout: Diagnosis
The diagnosis of gout - labs, imaging and polarized microscopy, created by @MithuRheum for RheumNow.
https://t.co/s8gkANFJSB https://t.co/pkUeFLG5if
Links:
Dr. John Cush RheumNow ( View Tweet)
Future therapies (in development) for gout - the goal is durable crystal depletion.
Created by: Dr. Aravind Palraj @rheumat_aravind for RheumNow.
https://t.co/yeCSAnHiY2 https://t.co/nH8f2Y3hNP
Dr. John Cush RheumNow ( View Tweet)
Calcium Pyrophosphate Deposition Dz new terminology from 2026 G-CAN consensus. Preferred:
- acute CPP crystal arthritis
- Chronic CPP crystal arthritis
- Chronic CPP crystal arthritis
- OA w/ CPP
- Chondrocalcinosis (xray)
* Pseudogout is obsolete
https://t.co/bsztXz9UDs https://t.co/GOey5YmKif
Dr. John Cush RheumNow ( View Tweet)
New GoutStop cards - print and give to your gout patients!
https://t.co/Bh0IuM5tzu https://t.co/j5rQJStSnu
Links:
Dr. John Cush RheumNow ( View Tweet)
Uricase-Targeted Therapies in Gout
https://t.co/RB6Yj4oY9a https://t.co/NrWq6Y93Hg
Dr. John Cush RheumNow ( View Tweet)
When Gout Flares, So Does the Cardiovascular System
We have spent decades teaching that a gout flare is a joint problem: a hot, swollen, painful joint that we treat with anti-inflammatory drugs and move on from (i.e., the treat to avoid symptoms strategy). The campaign title https://t.co/HCUQVaor4f
Dr. John Cush RheumNow ( View Tweet)
2 T2T RCTs of 383 gout pts starting allopurinol - 31% had tophi. At 12 mos achieving target uric acid (<0.36mmol/L) was same in pts with and without tophi (70.3 vs 73.6), as was the %gout flares in month 11 (71.4% vs 79.7%; p=0.21). Allopurinol T2T success not influenced by https://t.co/zr7K8Y2Bqz
Dr. John Cush RheumNow ( View Tweet)
Evidence-Based Dietary Recommendations for Gout
Gout, historically referred to as the “disease of kings,” was once associated with a lifestyle of excess. Today, it is more appropriate to refer to gout as a “disease of commoners,” as it is the most common inflammatory arthritis https://t.co/uIrSeOjxJZ
Dr. John Cush RheumNow ( View Tweet)
Pragmatism in Gout: How therapeutic choices can have multiple benefits
Drugs prescribed to calm flares or lower uric acid are designed with one primary goal in mind, yet many also produce meaningful effects beyond the joints. Some of those secondary effects are unwelcome; such https://t.co/QvXAwFM7LJ
Dr. John Cush RheumNow ( View Tweet)
