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INDIGO: Switching B Cells Off, Not Out, in IgG4-Related Disease

Henrique Dalmolin, MD

B-cell targeting has moved to the centre of IgG4-related disease treatment, with inebilizumab, a CD19 depleter, as the recent benchmark. At EULAR 2026, INDIGO tested whether the disease can be controlled by switching B cells off rather than depleting them.

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EULAR flags

Improving Understanding in SSc

2026 EULAR Press Release

Systemic sclerosis is a rare connective tissue disorder characterised by autoimmune features with vascular manifestations, causing fibrosis of the skin and internal organs. EULAR is focused on systemic sclerosis as the rheumatic disease with the highest morbidity and mortality. New data presented at the EULAR 2026 Congress underscore key complications, and offer hope for a possible new therapeutic strategy.

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question mark

Immune Dimming or Immune Reset in RA: How Far Should We Go?

Aurelie Najm, MD, PhD

CD19-directed CAR T-cell therapy has rapidly moved into autoimmune disease, driven in large part by striking reports in SLE, where sustained drug-free remission has raised the possibility of a true immune reset. In RA, where multiple effective therapeutic classes already exist, the relevance of such deep immune interventions remains uncertain.

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#EULAR2026 Want to catch up with the latest breakthrough in research on the last day of the conference? Please find our Day 4 Daily Recap led by @RheumNow and joined by my colleagues @synovialjoints @DrMiniDey 😃 https://t.co/fONe6g4ne1 https://t.co/kOqzF8t64w

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Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
RheumNow’s expanded coverage of the #EULAR2026 Annual Meeting is sponsored by Bristol Myers Squibb and UCB. RheumNow and its faculty independently select all coverage content.

Dr. John Cush RheumNow ( View Tweet)

Some new #vaccination #recommendations #EULAR2026 @RheumNow https://t.co/j7cOJPpOcV https://t.co/VnGkFwTZ86

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Janet Pope Janetbirdope ( View Tweet)
Remember Babies of pts on chronic #immunosuppression with #SARDs ❎delay #vaccinations til 6/12 For safety & to mount sufficient response #rotovirus #vaccine is Ok before 6 months or vaccine is ineffective Pts w #SARDs need #COVID shots @RheumNow #EULAR2026 #vaccine #recom https://t.co/WEzNajWlxY

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Janet Pope Janetbirdope ( View Tweet)
What’s new with the 2026 update of reco for vax in AIIRD? Vaccinate as soon as possible Non-live vaccines are safe Hold MTX for upto 2wks to inc vax yield Strong reco for RZV Catch-up vax for HPV in SLE Rotavirus vax for newborns exposed in utero to TNFi @RheumNow #EULAR2026 https://t.co/RZbyvAcYRI

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sheila RHEUMarampa ( View Tweet)
#EULAR2026 #SARD #vaccination #recommendations I think 🤔 ✅proactive➡️take responsibility ✅close gap ✅mostly practical But How long will #shingrix work if #vaccine In age<50yrs When if ever To revaccinate? @RheumNow @eular_org @ACRheum https://t.co/najJwzdecL

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Janet Pope Janetbirdope ( View Tweet)
Good performance of #definite #antisynthetase #syndrome ✅+antibody mandatory Possible also does ok @RheumNow #EULAR2026 June 6 #antisynthetase #classifiaction #criteria https://t.co/5sxogTX9YT

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Janet Pope Janetbirdope ( View Tweet)
Dr. Cavagna presents the 2025 EULAR/ACR Classification Criteria for Anti-Synthetase Syndrome He emphasizes the inportance of ruling out anti-MDA5 Ab & anti-PM/Scl Ab DM since these conditions share overlapping features w/ ASyS. @RheumNow #EULAR2026 https://t.co/AtGRlp5qyW

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sheila RHEUMarampa ( View Tweet)
How many patients with IBD have axSpA? POS1338 #EULAR2026 @RheumNow ⬇️⬇️⬇️ https://t.co/29qkrCnDYz

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Nelly ZIADE 🍀 Nellziade ( View Tweet)
Abstr LB0004 CC312 is a CD19/CD3/CD28 tri-specific T cell engager and sustains SRI-4 responses beyond one year with rapid, deep B-cell depletion in autoimmune diseases. Not CAR-T. Not a conventional biologic. A T cell engager that redirects your own immune cells to deplete B https://t.co/rTs3Rg7BPe

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Antoni Chan MD (Prof) synovialjoints ( View Tweet)
All content is independently chosen and produced by the RheumNow faculty. Our expanded #EULAR2026 coverage is made possible by support from Bristol Myers Squibb and UCB.

Dr. John Cush RheumNow ( View Tweet)

#EULAR2026 Updated recommendations on the management of PMR &LVV. A pleasure to have been part of this huge piece of work, covering 3 distinct conditions, and both diagnosis & management principles. Watch this space for full guideline coming soon! #EULAR2026 @RheumNow https://t.co/CUvaQVSU8k

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Mrinalini Dey DrMiniDey ( View Tweet)
Top 5 abst in #SjD #anifrolumab +RCT #ianalumab LTE Rx sustained #telitatacept +LTE #iana improves u/s parotids #TYK2 sig in#SjD OP0002, 0126, 127, 160 POS0284 #EULARbest #EULAR2026 @RheumNow @eular_org

Janet Pope Janetbirdope ( View Tweet)

Do GLP-1 agonists achieve meaningful weight loss in patients with RMDs? RISE registry Retrospective N=60,206 Tirzepatide: lost 8% Semaglutide: list 6% At 12 months PsA had the highest usage OP0112 #EULAR2026 @RheumNow https://t.co/P3CTgiwqCr

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Nelly ZIADE 🍀 Nellziade ( View Tweet)
#antisynthetase #EULAR/ACR #classification #criteria #EULAR2026 @RheumNow Based on >2k pts Probable v definite Ignore low + #synthetase #antibodies Seems reasonable and applicable ➡️my opinion https://t.co/MyCRiCSiGo

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Janet Pope Janetbirdope ( View Tweet)
Core definitions when understanding vaccination. @RheumNow #EULAR2026 https://t.co/wD0iTDxMEx

Links:

sheila RHEUMarampa ( View Tweet)
RheumNow’s expanded coverage of #EULAR2026 annual meeting is sponsored by Bristol Myers Squibb and UCB. RheumNow and its faculty independently select all coverage content.

Dr. John Cush RheumNow ( View Tweet)

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