All News

podcast logo

RheumNow Podcast – Bad Disease & Bad Outcomes (10.9.20)

d Jack Cush, MD

Dr. Jack Cush Reviews the news and journal articles from the past week on RheumNow.com.

Read Article
vasculitis.Churg-Strauss_syndrome.wikipedia.jpg

Biologics Beneficial in Eosinophilic Vasculitis

d

Two biologic therapies showed promise in the treatment of refractory or relapsing eosinophilic granulomatosis with polyangiitis (EGPA) in a retrospective European study.

Read Article
GPA.jpg

Sustained Remission Off Therapy Unlikely in GPA

d Jack Cush, MD

A French Vasculitis Study Group analysis of their granulomatosis with polyangiitis (GPA) reveals that after 10 years, only 7% of GPA patients achieved sustained remission off therapy (SROT) and have never relapsed.

Read Article
hip.THR_.jpg

IL-1 Inhibition Alters Arthroplasty Rates

d Jack Cush, MD

A subanalysis of the CANTOS trial suggests that inhibition of interleukin-1β (IL-1β) can reduce rates of incident hip or knee replacement (THR/TKR) surgeries.

Read Article
Fracture%20bone.png (keep)

Fractures from Delays in Denosumab Reinfusions

d Jack Cush, MD

Denosumab is effective in osteoporosis when used on schedue, but research suggests that discontinuation leads to rapid reversal of effect; a new observational study has shown that delays in denosumab administration of more than 16 weeks results in an increased vertebral fracture risk, according t

Read Article
microbes.jpg

Oral Dysbiosis May Antedate Rheumatoid Arthritis

d Jack Cush, MD

A study of oral microbiome in anti-cyclic citrullinated peptide (anti-CCP) positive at-risk individuals without synovitis (CCP+at risk) shows dysbiotic subgingival microbiomes and increased abundance of P. gingivalis compared with controls.

Read Article
steroids.prednisone.pills_.jpg

Systemic Steroids Reduce Mortality in COVID-19

d Jack Cush, MD

JAMA Internal Medicine reports an analysis of COVID-19 clinical trials showing that critically ill patients with COVID-19 treated with systemic corticosteroids have an overall lower mortality rate.

Read Article
Study of 193 Axial SpA pts with TNF inhibitor switching shows, using stringent outcome measures (ASDAS-ID) shows odds of responding to 2nd TNFi best w/ secondary TNFi failure (OR 7.3) or adverse events (OR 9.1), compared to primary TNFi failure. https://t.co/kpDelzBYRe

Links:

Dr. John Cush RheumNow ( View Tweet)

Study of 222 RA pts on MTX given anti-GMCSF (otilimab) 22·5 mg, 45 mg, 90 mg, 135 mg, 180 mg, or PBO weekly x 5 wks, then EOW. @wk 24 DAS28-CRP <2·6 5%, 16%. 19%, 14%, 14% respectively and 3% in PBO. Otilimab failed to meet primary endpoint. https://t.co/14QqyeTcuP

Links:

Dr. John Cush RheumNow ( View Tweet)

Comparison of 34,128 COVID and 84,585 influenza pts; COVID-19 patients have been more typically been male, younger, and have fewer comorbidities and lower medication use than flu. (data from USA, South Korea, Spain) https://t.co/VUzVxFdBra

Links:

Dr. John Cush RheumNow ( View Tweet)

Lockdown worsening; UK survey 678 patients musculoskeletal diseases pts in late April 2020 shows 53% worsening of Sx; 1/3 had clinic/hosp access probs problems & most (88%) had no probs w/ getting meds; but 44% needed others to help them get meds. https://t.co/3efmTdHhQx

Links:

Dr. John Cush RheumNow ( View Tweet)

Among 4766 mental health pts admited for Psychosis; 19% ANA tested and only 135 had a positive ANA >=1:160. (15% of those tested). Only 4 met 2019 ACR/EULAR criteria for SLE, and 2/4 met criteria for NPSLE. NPSLE prevalence was 1.5% in ANA+ psychosis Pts. https://t.co/c5C1VQaQAI

Links:

Dr. John Cush RheumNow ( View Tweet)

How pregnancy impacts nr-axSpA disease activity can vary from one woman to another, according to Eric Ruderman, MD, “I’ve had some patients who are better during pregnancy, and some who aren’t,” says Dr. Ruderman. Learn more about pregnancy and nr-axSpA: https://t.co/mC6YcG5lIx

Links:

NM Rheumatology NM_Rheumatology ( View Tweet)

To quash the virus, the immune system unleashes an arsenal. Sometimes these weapons turn inward and destroy healthy tissues. Combatting this friendly fire has become as crucial a part of the Covid-19 treatment strategy as subduing the virus itself. https://t.co/FrxVfSleEH

Links:

NYT Health NYTHealth ( View Tweet)

The AWIR San Diego, CA Virtual Summit CME Accredited : Worth 3.0 CEU Credits™ October 11th | Register Now: https://t.co/4vSqD0bxpk Join us on October 11th as we discuss Spondyloarthritis & the Spine, Telehealth regulatory updates, and more! For MD, NP, PA & PharmD Health Prof. https://t.co/QLXVJYjTD2

Links:

WOMEN IN RHEUM AWIRGROUP ( View Tweet)
https://t.co/EJD3z6ejkc
Dr. Dinesh Khanna sclerodermaUM ( View Tweet)
1) If you are have diffuse scleroderma and have previously participated in a clinical trial, we need your help! You will be asked to watch video tutorial and answer a survey which will take you 20 minutes to complete. the study is supported by @WeAreSRUK @scleroderma @srfcure

Dr. Dinesh Khanna sclerodermaUM ( View Tweet)

Incredible lecture on the highest of therapeutics for rheumatoid arthritis by @BrighamWomens Dr Michael Weinblatt. Love this screen shot of A to Z for therapies prior to the methotrexate era. Z=Zero therapy (do nothing). Incredible advances since then! https://t.co/AOIMBJiulo
Jeff Sparks jeffsparks ( View Tweet)
Classic bony erosion of gout is a punched-out, lytic lesion w/ a sclerotic margin & overhanging edge -- called a G sign, rat-bite erosion or the Martel sign, named after famed U MI radiologist Dr. William Martel who 1st described this gouty erosion in 1968 https://t.co/WJJUnjnnfl

Links:

Dr. John Cush RheumNow ( View Tweet)

European collaborative study of eosinophilic granulomatosis with polyangiitis (EGPA) Rx w/ RTX, mepolizumab or omalizumab (OMA). MEP > RTX > OMA. Mepolizumab was highly effective in GC‐dependent asthma. https://t.co/fi8pjnJO03

Links:

Dr. John Cush RheumNow ( View Tweet)

How well do you know this week's rheumatology news?
Take the rheumIQ quiz
Take the RheumIQ Quiz

×