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Opioids Double Rates of Suicides and Overdoses

d Jack Cush, MD

An article in the New England Journal of Medicine reports that the rates of suicide and drug overdoses has doubled in the last 17 years, and that opioids are largely to blame.

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BMS Buyout of Celgene for $74 Billion

d Jack Cush, MD

Reuters reports that Bristol-Myers Squibb (BMS) has announced its intention to buy Celgene Corp for nearly $74 billion in a cash-and-stock deal.

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RheumNow Podcast – A Grand New Year (1.4.19)

d Jack Cush, MD

Dr. Jack Cush reviews the news and journals for the beginning of 2019. All from RheumNow.com.

Best wishes for a charmed 2019! My advice: 1. Just show up. 2. If you can, then you must do. 3. Live each day as if it twas your 1st day/last day/make or break day. 4. Teach.

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2018 Rheumatology Year In Review

d Jack Cush, MD

This annual appraisal of hallmark moments, news and research articles from 2018 are gleaned from that published in RheumNow during the last year and filtered by other news sources and literature review.  The top 10 list herein is rooted in what rheumatologists should know and what will likel

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Uncertain Long Term Efficacy in Trials of Knee Osteoarthritis

d Jack Cush, MD

A systematic review and network meta-analysis of 47 randomized clinical trials in knee osteoarthritis finds uncertainty around estimates of effect size for pain scores thereby casting uncertainty over the long-term efficacy of medications for knee osteoarthritis.

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Sleep Apnea Increases Gout Risk

d Jack Cush, MD

Both Gout and obstructive sleep apnea (OSA) comingle with a wide range of serious comorbidities. A matched retrospective cohort study from the UK Clinical Practice Research database shows those with OSA are at a higher risk of developing gout.

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Obesity makes everything worse, including SLE! Study of 148 SLE pts; the 32% who were obese had worse disease activity, depression, pain and fatigue. https://t.co/PQOQrBca2a

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Dr. John Cush RheumNow ( View Tweet)

Rheumatology Year in Review - New Drugs, irAEs, Enbrel in court, Opioids, new JAKs, Hot PsA Trial, new Lupus drugs, Medical Marijuana, Expen$ive Rheum drugs, Senolytics. https://t.co/9VpM4yRGfY

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Dr. John Cush RheumNow ( View Tweet)

RheumNow Weekly Podcast is up - watch here: https://t.co/vAtEYSPIhG or listen on iTunes or here https://t.co/D3n7so7mN9

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Dr. John Cush RheumNow ( View Tweet)

Potential Blockbuster Takeover - BMS proposal to takeover Celgene for $74 Billion! Bristol-Myers' acquisition of Celgene would rank among the industry's largest ever. https://t.co/hWuygShcNq

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Dr. John Cush RheumNow ( View Tweet)

Learn about the pathophysiology, assessment & treatment of #psoriatic #dactylitis in our new #Perspectives article Now online at https://t.co/ewqx3xdXTz #PsoriaticArthritis #Arthritis #Enthesitis https://t.co/2bkHgKNGPQ

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NatRevRheumatol NatRevRheumatol ( View Tweet)
Happy birthday to the US Public Health Service Commissioned Corps. I’m proud of my colleagues who continue the Commissioned Corps’ 130-year legacy as the frontline defender of public health, providing critical health expertise and rapid response to public health emergencies.

Secretary Alex Azar SecAzar ( View Tweet)

2018 Rheumatology Year In Review | RheumNow - Rheumatology News & Information https://t.co/zo1AaWZ0MR

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Dr. John Cush RheumNow ( View Tweet)

FDA warns fluoroquinolone use may increase risk ofruptures or tears in the aorta. Thus Fluoroquinolones should not be used w/ aortic aneurysms, peripheral vascular Dz, HTN, Marfans/Ehlers-Danlos, or the elderly, unless there are no other options available https://t.co/aTEE0keIS8

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Dr. John Cush RheumNow ( View Tweet)

Finnish followup study of 68,800 hip fracture pts w hip surgery finds 4.6% w/ complications - esp with heavy alcoholism (HR 1.38); Parkinson’s (1.22); osteoarthritis (2.02); rheumatic Dz (1.44); those w/ depression/psychosis, operative delay, prior THR https://t.co/StahnHXRuZ

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Dr. John Cush RheumNow ( View Tweet)

Chronic Urticaria associated with a 23% higher risk of osteoporosis, irrespective of steroid use. Population study from Israel compared 11,944 Chr urticaria w/ 59,829 controls. (HR = 1.23, 95% CI 1.10–1.37, p <0.001) https://t.co/eSq4BPV2J4

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Dr. John Cush RheumNow ( View Tweet)

Analysis of pegloticase clinical trial data shows that tophus resolution was achieved by 69.6% of 23 responders, 27.9% of 43 nonresponders, and 14.3% of 21 patients who received placebo. Resolution time = 9.9 mos. https://t.co/4Pu16t3BV8

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Dr. John Cush RheumNow ( View Tweet)

Case series compared 247 pregnancies in IgA Vasculitis patients vs 556 control pregnancies showing IgA Vasculitis had no effect on fertility and did not induce flares. But IgAV had more spont. abortions, gestational HTN, preterm delivery. https://t.co/uJirv32UYc

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Dr. John Cush RheumNow ( View Tweet)

“A goal without a plan is just a wish” ― Antoine de Saint-Exupéry

Dr. John Cush RheumNow ( View Tweet)

Pulmonary arterial hypertension is a very uncommon complication of Adult onset Stills disease - 4.8% of 41 AOSD pts developed PAH - often severe, with a mortality risk. https://t.co/XjyVArMNBl

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Dr. John Cush RheumNow ( View Tweet)

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