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Higher Lupus Mortality Among Minority Populations

Jack Cush, MD Feb 23, 2021

The February 19th MMWR reports that higher mortality rates in certain patients with systemic lupus erythematosus (SLE); data based on recent San Francisco County statistics showing a four fold higher mortality among Asian and Hispanic/Latina females with SLE.

Article

ANAGO Study - Anakinra for Gout Flare

MedPage Today Feb 23, 2021

The interleukin (IL)-1 receptor antagonist anakinra (Kineret) was not superior to triamcinolone for relieving gout flares, but had similar effects for pain reduction as the glucocorticoid, a randomized phase II study found.

Article

Diagnosis & Treatment of Osteoarthritis Reviewed

Jack Cush, MD Feb 22, 2021

Katz, Arant and Loeser have published a comprehensive open-read overview of osteoarthritis (OA) of the hip and knee in JAMA; underscoring the impact, advances, disappointments and guidelines put forth.

Cohort analysis of 12351 RA patients from CPRD registry - finds RA on both glucorticoids & PPI have a greater risk OP fractures (adj HR: 1.60, 95% CI: 1.35 to 1.89) vs non-use. Higher than the Fx Risk with either oral GC or PPI use alone (adj HR 1.2). https://t.co/oPMnJoHCjX https://t.co/eW7rpVeHa4

https://bit.ly/2Pa9igc

Retrospective cohort study shows the risk of RA was lower in T2DM/diabetes (aHR 0.73; 95% CI 0.67–0.79) vs without T2DM. This risk was lost in when statins were not used (aHR 0.89; 0.69–1.14). Statins (in T2DM) had a protective effect against RA onset https://t.co/CfMJIuGOXI

https://bit.ly/3qTcivh

These companies do autoinflammatory gene testing in the USA. @RWCSmtg https://t.co/KiJ1wbyihw

Have you registered for RheumNow Live yet? Attend 3/20-3/21 in Fort Worth, TX or virtually! https://t.co/uwxOVh142F https://t.co/DXZPp8wJkv

https://bit.ly/3raRbVb

News Feature: Diagnosis & Treatment of Osteoarthritis Reviewed Katz, Arant and Loeser have published a comprehensive open-read overview of OA of the hip and knee in JAMA; underscoring the impact, advances, disappointments and guidelines put forth https://t.co/VVnUk02KiP https://t.co/97dFC56Jcb

https://bit.ly/3qOwQ8a

QD Clinic - PFAPA Syndrome Recurrent Fevers, Stomatitis, Lymphadenopathy ? https://t.co/uMBk8e2wJO https://t.co/LIs02svEDB

https://bit.ly/3dKPeeJ

We are excited to announce that Jeff Sparks ( @jeffsparks) will be leading a discussion on ILD in RA at RheumNow Live this March. Register to attend today. https://t.co/uwxOVh142F https://t.co/bnittqkhKQ

https://bit.ly/3raRbVb

Lung Preservation w/ Tocilizumab in Early Systemic Sclerosis Arthritis & Rheumatology has published the results of a subanalysis from TCZ clinical trials showing that Il-6 inhibition is related with preservation of lung function patients with early SSc. https://t.co/2BwWQWEkri https://t.co/pjVc8YTDwU

https://bit.ly/3ke9W7M

QD Clinics- The Sawtooth Steroid Taper Sawtooth Steroid Taper Surgery Rules for DMARDs & Biologics RA & DVT Traveling to Medical Meetings during COVID Hemoptysis and SLE When to do Genetic Testing in Febrile Patients https://t.co/dZLqGUyizG https://t.co/PYsH7K6ByB

https://bit.ly/2ZGAipq

A San Paolo study of the relevance of anti-Jo-autoAbs in 118 dermatomyositis patients; 8.5% of whom were Jo-1 positive. Jo-1+ had more "mechanic's hands," joint and lung disease; & low/no chance for remission and more steroid & immunosuppressive use https://t.co/yv51txWZCa https://t.co/fLu4PH0e9C

https://bit.ly/3k7aJaE

Rumor has it I won the"Slow Bike Race" in 3rd grade at field day. How to win the Slow Bike Race? Slow and steady, Focus, Balance, Economy of Effort, Think More-Pedal Less and Pay No Attention to the Competition. https://t.co/04XbS5FSlK

Data from Danish Medical Birth Register shows PREG women w/ spondyloarthritis have more adverse pregnancy outcomes - including preterm birth (OR 1.5), elective C-section (OR 1.44), & epidurals (OR 1.11). Not increased were preeclampsia & rate small wt. https://t.co/opYsOBAR6A

https://bit.ly/2ZAoTYr

Survery of 438 RHEUMS on #AS & SpA - half use mod NY & ASAS criteria. 3/4 say Inflammatory Back Pain is axSpA specific, ~1/2 say uveitis/dactylitis are “very specific; less so heel enthesitis, peripheral arthritis. SI MRI was mor common w/ younger Rheums https://t.co/xfjvK5TO0t

https://bit.ly/2OZ3UfP

Medscape has published the 2021 Rheumatologist Lifestyle, Happiness & Burnout Report. Happy went down during COVID 79% to 49% 32% burnt out; 11% depressed 51% have workplace issues Half take 3-4 wks vacation https://t.co/g8UAHtiLIB

https://wb.md/2ZB58zI

Single center study of 43 pregnant SLE pts (57 pregnancies) - 96.5% intended to breast feed & 72% did (same as gen population). But SLE women had more early discontinuations @ 3 mos (assoc w/ smoking, BMI, joint Dz) HCQ assoc w/ longer breastfeeding https://t.co/VVVTVUeOT5

https://bit.ly/3pFiKVl

Population based study of smoking cessation & risk of TKR in knee OA. TKR higher in recent quitters (26.7/1000PY vs 17.4/1000PY in smokers). adjusted HR=1.30 (95%CI:1.05-1.59). TKR risk was higher among quitters with weight gain (HR=1.42) https://t.co/6onQWQeFcI

https://bit.ly/3kayRck

CTD associated pulmonary HTN has improved sincd 2010. Metanalysis of 11 RCTs (4,329 pts) & 19 registries (9,739 pts); 5 RCTs find PAH Rx assoc w/ 36% lower mortality/morbidity. Registry data shows better PAH survival since 2010 (73% vs 65% @3yrs) https://t.co/0BkO70AQfi

https://bit.ly/3dBdLTs

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All News

Higher Lupus Mortality Among Minority Populations

ANAGO Study - Anakinra for Gout Flare

Diagnosis & Treatment of Osteoarthritis Reviewed

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