All News

Liver.hepatitis.jpg

Hepatic Safety of Urate Lowering Therapies in Gout

d Jack Cush, MD

Lee and a group of Korean investigators have analyzed the comparative safety of allopurinol and febuxostat in a small cohort of gout patients with fatty liver disease (FLD) and found febuxostat had a lower risk for hepatotoxicity (defined as AST or ALT at least 3× the upper limit of normal)

Read Article
Lupusfoto.jpg

Diagnosing Early Lupus from Mimics

d Jack Cush, MD

A multicenter study of early systemic lupus erythematosus (SLE) patients examined manifestations at disease onset and found that certain clinical features can help to distinguish early SLE from other SLE‐mimicking conditions. 

Read Article
heart.jpg (keep)

High CV Risk in Lupus

d RheumNow

Patients with systemic lupus erythematosus (SLE) remain at risk for accelerated atherosclerosis, and important questions have yet to be answered, British investigators reported.

Read Article
falls.jpg (keep)

Trazodone High Risk of Falls and Fractures

d Jack Cush, MD

The CMAJ (Canadian Medical Association Journal) has reported that trazadone use in the elderly may be associated with a risk of falls and major fractures. 

Read Article
Claims data study from Germany looked at OA of hip or knee in adults > 60 yrs finding 595,754 pts (mean 75 yrs; 70% female) Dx with OA (21.8%); 63% received analgesics, higher with increasing age. PT in 43.1% and 5.3% w/ joint replacement in 2014. https://t.co/shLSlDeO9h

Links:

Dr. John Cush RheumNow ( View Tweet)

CDC review of new syndrome Acute Flaccid Myelitis - 106 cases in 2018, mostly white (86%), children (median 4 yrs) w/ rapid onset of flaccid weakness in one or more limbs and spinal cord gray matter lesions. Evidence suggests a viral association. https://t.co/C5FHAHMHI9

Links:

Dr. John Cush RheumNow ( View Tweet)

Clinical Expectations of Biosimilars is one of several educational videos available in the "Therapeutic Update: Biosimilars in Rheumatology" video series, sponsored by Sandoz, Inc. and now available on RheumNow. https://t.co/1vmnEJqOSi

Links:

Dr. John Cush RheumNow ( View Tweet)

Musculoskeletal/Rheumatic diseases (arthralgias, myalgias, arthritis, PMR, myositis, Sjogrens, SLE) are uncommon side effects of immune checkpoint inhibitors, so-called irAE (immune related adverse events). Good review here. https://t.co/R52SW0HUjv

Links:

Dr. John Cush RheumNow ( View Tweet)

Despite many excellent therapies, most patients with gout are not adequately managed, and patients and providers have many misconceptions about gout. Great review by Ted Fields, MD https://t.co/Njpo1225XP

Links:

Dr. John Cush RheumNow ( View Tweet)

Bisphosphonate safety review - risk of Atypical Femoral Fracture is 1/1000 and risk of osteonecrosis of the jaw is 1/10,000. One-third of IV zolendronic acid pts will have arthralgia/myalgias or flu like sxs. https://t.co/80xBkZlKgn

Links:

Dr. John Cush RheumNow ( View Tweet)

TB Testing 2 - Note: <10% of pts initially PPD/IGRA neg may be positive later (either they were anergic or have a new TB infx). I Recommend repeat TB testing 3 mos after starting or changing from 1st to 2nd biologic - Repeat testing indicated if newly EXPOSED or when Risk Changes

Dr. John Cush RheumNow ( View Tweet)

TB Testing - Do PPD or IGRA before TNFi or biologic - If negative, start therapy - If Positive, Eval for active TB (Sxs, CXR, C/S); if neg --> LTBI Rx BEFORE biologic - If "Indeterminate", repeat or change test. If same or neg--> start biologic - Do not do annual TST or IGRA

Dr. John Cush RheumNow ( View Tweet)

Metanalysis shows DMARDs (6 studies) and biologics (5 studies) offer NO clinically significant benefit compared with placebo in Osteoarthritis. https://t.co/fNGVzuNQNo

Links:

Dr. John Cush RheumNow ( View Tweet)

Vasculopathy (inflammatory, occlusive, necrotizing) distguishes juvenile dermatomyositis from adult myositis - also w/ high risk of severe extra-muscular dz (GI, Lung, cardiac, skin). Good review article here https://t.co/yH8xwKl6S8

Links:

Dr. John Cush RheumNow ( View Tweet)

Could routine use of hydroxychloroquine reduce the rate of serious infections in immunosuppressed patients? A modest to moderate risk reduction noted in two large SLE cohort studies. https://t.co/pssLrteRRq

Links:

Dr. John Cush RheumNow ( View Tweet)

2018 NRMP report shows Rheumatology as one of the most competitive fellowships with 313 applicants for 221 positions - 147 filled by US grads and 69 by FMGs. https://t.co/xRmMyA2yCy

Links:

Dr. John Cush RheumNow ( View Tweet)

Clinical Trials Benchmark for Biosimilar Development is one of several educational videos available in the "Therapeutic Update: Biosimilars in Rheumatology" video series, sponsored by Sandoz, Inc. and now available on RheumNow. https://t.co/1vmnEJqOSi

Links:

Dr. John Cush RheumNow ( View Tweet)

J Rheum (Ward et al) reports that the minimal clinically important improvement (MCII) of RAPID-3 was –3.8. https://t.co/UxCOeMl52g

Links:

Dr. John Cush RheumNow ( View Tweet)

The "Type" of person you are often is displayed with how you manage authority

Dr. John Cush RheumNow ( View Tweet)

CORRECTION: mm! Guidelines on CT pulm nodules-no F/U needed for solid nodules <6mm in low risk pts (age,smoking, morphology); but larger (6-8mm), suspicious nodules should have 6 & 12 mos F/U images. Some 8cm or more nodules require more freq assessments https://t.co/Nl6zV3VQg1

Links:

Dr. John Cush RheumNow ( View Tweet)

Do you get our email newsletter?

Looking for the latest rheumatology news & trends? Sign up for the RheumNow weekday newsletter:

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Rheumnow.com is a news source dedicated to the field of Rheumatology. It is written by experts in the field, and written for rheumatologists and individuals working in related fields. Rheumnow.com provides daily updates on the site and in your inbox when you are signed up for our newsletter.

Copyright 2024 All Rights Reserved.

×