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NEJM: Interleukin-6 Inhibition in Critically-Ill COVID-19

Jack Cush, MD Mar 01, 2021

The pendulum and jury are wavering with regard to the benefits of interleukin-6 receptor antagonists in COVID-19; the current NEJM reports the results of a study favoring such biologic therapy in in critically ill COVID-19 patients.

Article

MAXIMISE Trial - Secukinumab Efficacy in Psoriatic Spondylitis Patients

Jack Cush, MD Feb 26, 2021

The results of the novel MAXIMISE trial have been published, demonstrating that secukinumab significantly improved axial signs and symptoms in psoriatic arthritis patients with axial manifestations with inadequate NSAID response.

Influenza vaccinations may hit a record high this season. Last year 48.4% of Americans got the flu shot. Survey suggests that nearly two-thirds will have flu vax this year (44% already had a flu shot, 13.5% said they will get& 9.3% said probably will get) https://t.co/3CnIdx49rW https://t.co/Khp6wsahCD

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Report from DANBIO Danish register looked at chronic pain in a matched cohort study of Psoriasis. Chronic pain was not associated with excess mortality (hence not PsA) (OR 0.99,0.95-1.03). Mortality was increased with steriods, COPD, DM, CA, CV disease. https://t.co/91JW3BOPtw

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News Feature: NEJM: Interleukin-6 Inhibition in Critically-Ill COVID-19 https://t.co/IrKnTlPDpK https://t.co/8topsI3nQN

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QD Clinic - Self-Medicating Myself Getting pills from Mexico, Spouse or the Dog? https://t.co/jcAmyhihN5 https://t.co/68UMEVCM6W

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Top February Tweet: ACR Task Force published guidelines on RMD drug use w/ COVID vaccines. My views: 1. I agree, no change most DMARD, biologics 2. I disagree; I would NOT hold Orencia, I would NOT hold JAKi 3. I disagree: I would not hold MTX https://t.co/uSPfvJB8EC https://t.co/unOY1jvzTJ

https://bit.ly/3p7PPJh

Compared with no statin use; statin use in RA pts is assoc w/ 28% lower mortality risk. Population study of 19,614 RA pts w/ incident statin use, compared 1,883 statin users vs 1,883 nonusers. All-cause mortality was lower (HR 0.72;0.56-0.91) w/ statins https://t.co/onMlWoVdPL

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News Feature: Measureable Benefits to Treat-to-Target Management in RA https://t.co/iAvLWJGTXp https://t.co/NfNj3MWznI

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RheumNow Live is a powerful, interactive meeting delivered by researchers, educators, & clinicians. The speaker list includes: Roy Fleischmann, Alan Matsumoto, Clay Cockerell, Eric Ruderman, Alexis Ogdie, Philip Robinson, Jeff Sparks, and more. https://t.co/vJlU0Z3Q3x https://t.co/fRbQbGRwoR

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Pooled analysis of 16 observational RA registries (27 583 patients) shows that seropositivity was associated with better remission, LDAS and withdrawal rates for RTX and ABA, but not TNF inhibitors. https://t.co/aNphJpB7JB

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QD Clinic: PFAPA Syndrome Recurrent Fevers, Stomatitis, Lymphadenopathy ? https://t.co/uMBk8e2wJO https://t.co/02ZMjRmOuU

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Systemic Sclerosis is 5 times more prevalent in women than men. Analysis of epidemiology studies shows SSc prevalence as 17.6 per 100000 and pooled incidence of SSc was 1.4 per 100000 PYs. https://t.co/RyVIBUWyen

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Its sill not SAFE! Avoid congregate settings! CDC report shows among 81 who participated in indoor high-intensity exercise classes - 68% developed COVID-19. 40% with COVID-19 attended class on day Sxs began. Most (76%) wore masks infrequently https://t.co/KLZauJUupN

https://bit.ly/2Pax4IP

In Israel (as of Feb 2021) 84% of those ≥70 years and 10% for <50 years have received 2 doses of the COVID Vaccine; as such the need for mechanical ventilation in the elderly has declined 67% with the implementation of COVID vaccines. https://t.co/9Qnv72QYUS

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Listen to last weeks QD Clinics Podcasts (134-137 Feb 26) - RA or Not QD137 - RA or Not QD136 - Periorbital Mass QD135 - Periorbital Edema QD134 - PFAPA Syndrome https://t.co/pMXm6vFuBl

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My Experience as a COVID19 Vaccine Trial Participant https://t.co/ILfXLUL8IZ

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QD Clinic - RA or Not? Lessons from the clinic. Enough serology, but not enough joints - when does it become RA? https://t.co/akklOklPee

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News Feature: MAXIMISE Trial - Secukinumab Efficacy in Psoriatic Spondylitis Patients https://t.co/34RU4OSaRi

https://bit.ly/3syHWyx

News Feature: Higher Lupus Mortality Among Minority Populations https://t.co/l4xUz9se02 https://t.co/UsGRc2twWU

https://bit.ly/2ZOYZA7

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NEJM: Interleukin-6 Inhibition in Critically-Ill COVID-19

MAXIMISE Trial - Secukinumab Efficacy in Psoriatic Spondylitis Patients

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