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No Link Between Autoimmune Diseases and Monoclonal Gammopathy of Undetermined Significance
Annals of Internal Medicine reports a study of more than 75,000 persons screened for monoclonal gammopathy of undetermined significance (MGUS) and found no association between autoimmune rheumatic disease (AIRD) and MGUS.
JAMA full read comprehensive review of 'Chronic Pruritus' affecting 22%, 1% of all out pt visits
- Dx algorithm
- Pathophys
- Rx options
- Alternative Rx
https://t.co/epiP8Yi1Oz https://t.co/GsORbADJZy https://t.co/K7Q6Yrx1yI
Dr. John Cush RheumNow ( View Tweet)
There's a huge difference between knowing the name of something and knowing something.
We talk in fact-deficient, obfuscating generalities to cover up our lack of understanding.
Prof. Feynman ProfFeynman ( View Tweet)
Do you have a rheumatology question or case for Dr. Cush? Record it here and we may feature it on an upcoming podcast. Tell us your name and where you practice rheumatology.
https://t.co/qvVEUoNYi5 https://t.co/duw6jg5xpp
Dr. John Cush RheumNow ( View Tweet)
No Link Between Autoimmune Diseases and Monoclonal Gammopathy of Undetermined Significance
Annals of Internal Medicine reports a study of more than 75,000 persons screened for MGUS and found no association between AIRD and MGUS.
https://t.co/F8diWbUYPf https://t.co/M53Dgphcge
Dr. John Cush RheumNow ( View Tweet)
Lille Univ Hosp study of 485 systemic sclerosis pts, found osteoporosis in 23% (18% w/ fragility Fx). OP independently linked to age (OR1.06), topoisomerase I Ab+ positivity (OR 2.22) & GC treatment (OR 4.48) https://t.co/9KN5VQnl4A https://t.co/L7RwDdzaFZ
Dr. John Cush RheumNow ( View Tweet)
Consensus Statements on Vitamin D
The “Controversies in Vitamin D” International Conference has published their proceedings on vitamin D metabolism, assessment, actions, and supplementation.
https://t.co/QGXbJdJpAC https://t.co/N1UkTi6u8C
Dr. John Cush RheumNow ( View Tweet)
Alot of murky "research" on Platelet-rich plasma (PRP). This RCT of120 pts having anterior cruciate ligament reconstruction (half randomized to PRP) shows no PRP benefit, no significant improvement of knee symptoms & function post ACLR https://t.co/AwkCAq1QFb https://t.co/YP0hJd7soc
Dr. John Cush RheumNow ( View Tweet)
K Kuhn et al: Altered tryptophan catabolism by microbiome may contribute to inflammatory arthritis. Tryptophan increases indole leading to ncreases in serum IL-6, TNF, and IL-1β; splenic RORγt+CD4+ T cells, & IL-23 and IL-17 production https://t.co/i9le12QZm2 https://t.co/akeXxWnQ9o
Dr. John Cush RheumNow ( View Tweet)
Infectious Mortality in ARD
Infectious conditions are a significant cause of mortality in ARD. Among patients hospitalized with an infection, we compared in-hospital and long-term (3-year) mortality between those with and without ARD.
https://t.co/p4n5Los89F https://t.co/vUBLC9TDDG
Dr. John Cush RheumNow ( View Tweet)
Save the date! We’ll be covering #EULAR24! https://t.co/HGjP2SFyOp
Dr. John Cush RheumNow ( View Tweet)
NEJM: evolution of pyoderma gangrenosum skin lesions https://t.co/wE9pAZZs9L https://t.co/jTijcCvpfI
Links:
Dr. John Cush RheumNow ( View Tweet)
JAMA Case: Scurvy in a 3 yr old w/ Gingival Hemorrhage and Musculoskeletal Pain. limp and increased bilateral limb weakness with inability to bear weight. Diet: mostly chicken nuggets and milk https://t.co/e3kpEXNl3K https://t.co/D4u56I0PSq
Dr. John Cush RheumNow ( View Tweet)
NEJM: evolution of pyoderma gangrenosum skin lesions https://t.co/vsgQhsjY5q https://t.co/INrbTIc9kX
Links:
Dr. John Cush RheumNow ( View Tweet)
In 530 #GCA pts, relapses seen in 46%; but severe relapse (ischemi/aortic events) in 3%. Severe GCA relapse pts more likely to be younger at Dx(P=0.02), w/ more limb claudication(< 0.0001), fewer GCA-related cranial Sxs (<0.0001); but not higher mortality https://t.co/k7wgU6oMcn https://t.co/BKOfGmZ27u
Dr. John Cush RheumNow ( View Tweet)
Biomarker Predictors of Osteoarthritis
Science Advances has reported that Duke University researchers have validated a biomarkers of osteoarthritis that may be identified 2 years before the appearance of radiographic OA. S
https://t.co/z5Tg9pAgqO https://t.co/ltY4rEg9p3 https://t.co/AjCKaUW59X
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Dr. John Cush RheumNow ( View Tweet)
Full-read Overview of Macrophage Activation Syndrome - a rare complication of autoimmune inflammatory rheumatic dz; assoc w/ Still’s disease SLE, Kawasaki, dermatomyositis, RA, Sjögren’s. Precipitating factors, including genetics & infections reviewed https://t.co/LmL3BPmo6c https://t.co/OkfwpzNLAL
Dr. John Cush RheumNow ( View Tweet)
🏆Dr. Georg Schett's pioneering work in CAR-T for #autoimmune disease has landed him among the TIME100 Most Influential People in Health
“Not only are the patients in drug-free remission, but I believe many are cured of their autoimmune disease," he said
https://t.co/Rj7FpkluNg
Links:
Healio Rheumatology HealioRheum ( View Tweet)
Articular Findings Sarcoidosis:
- Acute arthritis: Lg Jt Oligoarthritis; Loffgrens syndrome (hilar LN, arthritis, E. nodosum)
- Acute > Chronic arthritis
- Chronic arthritis: tenosynovitis, oligo- &polyarthritis, dactylitis, erosions or Jaccouds arthritis
Dr. John Cush RheumNow ( View Tweet)
Prospective look at 25 280 older adults (mean 74yrs) w/ incident fracture, shows impact of multimorbidity by Charlson Comorbid Index (CCI). If CCI =2-3, Incr risk of subseq Fx (16-25%) & death (HR ~2); If CCI=4+, Fx Risk ^33-48%, death HR~4. https://t.co/6wnhFNiSXH https://t.co/Xy2y0ANDRd
Dr. John Cush RheumNow ( View Tweet)
