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TNF Inhibitors Reduce and Stabilize Coronary Plaque

Jack Cush, MD Apr 27, 2020

Arthritis & Rheumatology reports that biologic (bDMARD) use in rheumatoid arthritis may decrease cardiovascular disease risk by retarding coronary plaque formation and progression (especially non‐calcified and low‐attenuation plaque).

Article

High Dose Chloroquine Harmful in Severe COVID-19

Jack Cush, MD Apr 27, 2020

JAMA Open Network reports an interim analysis of the Brazilian CloroCovid-19 trial showing thta higher doses of chloroquine (CQ) in the treatment of severe COVID-19 was associated with QTc interval prolongation and increased mortality.

Article

RheumNow Podcast – In Times of Trouble (4.24.20)

Jack Cush, MD Apr 24, 2020

Dr Jack Cush reviews the news, journal reports, twitter feed and COVID developments from the past week on RheumNow.com

French retrospective study of 429 pts (302 SpA, 127 PsA) compared 203 on TNF inhib mAb vs 226 on etandercept as 1st TNFi. The probability of uveitis during the 1st yr was lower with ETA but not signif different than mAbs (OR 0.94; 0.35; 2.54) https://t.co/jCSxL0hh7H https://t.co/cCSyVqgd6w

Occurrence of anterior uveitis in patients with spondyloarthritis treated with …

Matched case control study of 94 SLE patients with diffuse alveolar hemorrhage finds Lupus nephritis, +SSA, thrombocytopenia & high CRP were independent risk factors for DAH. SLE-DAH pts had signif higher mortality (adjHR 6.0; 2.8–13.0). https://t.co/OUtSqXTGnw https://t.co/3myioyHqvc

SAGE Journals: Your gateway to world-class journal research

"Permanence, perseverance and persistence in spite of all obstacles, discouragements, and impossibilities: It is this, that in all things distinguishes the strong soul from the weak." - Thomas Carlyle

Health Canada issued a safety alert noting Chloroquine & hydroxychloroquine can have serious toxicities & should only be used under a physicians supervision. Due o concern that some may be directly buying/using CQ/HCQ to treat/prevent COVID-19 https://t.co/ksxveHADZX

Chloroquine and hydroxychloroquine can have serious side effects. These drugs s…

Sanofi announced early results of phase 2 trial of IL6 inhibitor, sarilumab, showing benefit only in Critical COVID-19 pts. 457 pts given IV Kevzara 400 mg vs 200 mg vs PBO , high dose had fewer deaths (32 v 46 v 55%) & more D/C (53 v 39 v 41%). https://t.co/6q21qJNj2C

Sanofi and Regeneron provide update on U.S. Phase 2/3 adaptive-designed trial i…

On April 24, FDA issued a Drug Safety Communication stating HCQ and CQ have not been shown to be safe and effective in COVID-19 and that HCQ/CQ should not be used outside of hospitalized or pts in clinical trials. https://t.co/l2DNBhhvTR

FDA cautions against use of hydroxychloroquine or chloroquine for COVID-19 outs…

Informative, straight forward, well done video of the SHOULDER Exam! https://t.co/AQetQjvQP1

Shoulder Exam I | Protocol

"Quantity and persistence will get you the outcomes you need." - James Altucher

The RheumNow Podcast is up! "In times of Trouble". Watch it here>> https://t.co/gapTwq3REW or listen to the podcast on iTunes or SoundCloud>> https://t.co/dpoCoX8qBR

"Yeah, you might beat me today, but then you’re gonna have to fight me again tomorrow and the day after that and every single day from now on until I kick the #$%! out of you, which I will.” - William Costanzo

The RheumNow Podcast is up! "In times of Trouble". ABA and DM, Zostavax fails, 3d Doubling rate, population testing, HCQ in COVID; Watch it here>> https://t.co/gapTwq3REW or listen to the podcast on iTunes or SoundCloud>> https://t.co/dpoCoX8qBR

"Stay in your seat come times of trouble. Its only people who jump off the roller coaster who get hurt." - Paul Harvey

Perhaps love is like a resting place, a shelter from the storm. It exists to give you comfort, it is there to keep you warm, and in those times of trouble when you are most alone, the memory of love will bring you home." - John Denver

There’s a saying that anyone driving faster than you is crazy and anyone driving slower doesn’t know how to drive. Similar with COVID-19: anyone taking more precautions than you has an anxiety issue and anyone taking fewer is an idiot.

Dr C Kershaw @UTSWNews grand rounds on ventilation in #COVID19 Why putting pts in prone position might help with ARDS ⁦@RheumNow⁩ https://t.co/I0AOx72Jwl

ACR Guidance for Rheumatic Disease during COVID-19 pandemic #Rheumatology @RheumNow https://t.co/vHav6g4p6Q

NICE guidelines on managing rheumatologic conditions during COVID-19 #Rheumatology @RheumNow https://t.co/dQcavsno5N

Topics

All News

TNF Inhibitors Reduce and Stabilize Coronary Plaque

High Dose Chloroquine Harmful in Severe COVID-19

RheumNow Podcast – In Times of Trouble (4.24.20)

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