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A composite risk score that included three biomarkers predicted thrombotic events among patients with systemic lupus erythematosus (SLE), a cross-sectional study found.
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Reuters reports on regulatory efforts by Canada and the US to curb the rising cost of drugs, especially expensive new medicines.
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An unusual pilot study has shown that insulin resistence (IR), assessed by Hgb-A1c levels, was more prevalent in fibromyalgia (FM) patients compared to non-diabetic controls and that when FM patients were given metformin, half had complete resolution of their pain.
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Systemic lupus erythematosus (SLE) is an autoimmune disease with a propensity to develop glomerulonephritis (47-70%) or end-stage kidney disease despite therapy.
Dr. John Cush
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"Everyone Needs A Coach" my TED-like talk from RheumNow Live 2019. https://t.co/G4jengfX0X
Dr. John Cush
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FDA has approved Ruzurgi (amifampridine) for Lambert-Eaton myasthenic syndrome in children 6-17 years. Drug works by blocking potassium channel efflux in nerve terminals, opening Ca2+ channels & increasing acetylcholine release https://t.co/y7JFr76PTr
Dr. John Cush
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Long term safety of Secukinumab in PsO, PsA, & AS RCTs ( 96,054 patient-years) - favorable results with low incidence of serious infx (1.4, 1.9, 1.2, /100PYs), Candida (2.2, 1.5, 0.7/100pYs), IBD (0.01, 0.05, and 0.1/100PYs) or MACE (0.3, 0.4, 0.6). No TB. https://t.co/BTbBlOYj8W
Dr. John Cush
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In mice infected with the ZIKA virus, use of IL-1 receptor antagonist therapy mitigates placental dysfunction and perinatal injury by inhibiting microglial activation in the perinatal brain and by direct effects on the placenta. https://t.co/pgcOBoXMux
Dr. John Cush
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Danish population study of 55,037 found 210 men (37.6% RF+) & 456 women (41% RF+) RA pts; In women, body fat%, waist size, & obesity was assoc. w/ higher risk of RA. (10% higher for each 5% body fat, 5% for each 5- cm in waist, & 50% higher for obese) https://t.co/PRUBWcWXjC
Dr. John Cush
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Claims comparison of venous thromboembolic events (VTE) in treated RA pts finds a nonsignificant, but numerically higher rate of VTE in TOFA vs TNFi pts (0.60/100PY vs 0.34/100PY) (1.12/100PY vs 0.92/100PY), respectively. HR 1.33 (95% CI 0.78–2.24). https://t.co/JygSou07B1
Dr Philip Robinson
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A bit of welcome data on this -> Abatacept concentrations in maternal serum and breast milk during breastfeeding and an infant safety assessment https://t.co/TypfZZgcdK
Dr Philip Robinson
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New data on tocilizumab in pregnancy, upshot is: "Tocilizumab concentrations in cord blood and infant serum were 80–90% of those in maternal serum" https://t.co/qV7758L4Pm
Dr. John Cush
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In first-degree relatives of RA patients, comparing ACPA pos and neg FDR finds all moderate to severe periodontitis was significantly more prevalent in ACPA+ FDR (91%) compared to ACPA neg FDR (40%). From the Journal of Clinical Periodontology https://t.co/5d4YKGszZO
Dr. John Cush
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The RheumNow Podcast is up – DESIREABLE Results (5.3.19) WATCH it here https://t.co/uyYKxw21Kd or listen to the PODCAST on iTunes (Apple Car Play) or SoundCloud here>> https://t.co/HW0aDJo90Q
Dr. John Cush
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Cohort study finds 6/420 (1.4%) of SLE patients had steroid induced pancreatitis is - half of them died. Lit review finds 451 lupus pancreatitis with majority developing pancreatitis w/in 3 days of medium-to-high dose steroids (mortality = 37.5%). https://t.co/QsIHsl44qx
Dr. John Cush
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“..the only difference between those who have failed and those who have succeeded lies in the difference of their habits —I will form good habits and become their slave. - from The greatest Salesman in the World
Dr. John Cush
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Eight Survival skills (cont) 5) Set a daily goal and track your progress. 6) find a daily "hassle" & reframe it in a more positive light. 7) Do something nice for someone else each day. 8) Practice mindfulness by paying attention to the present moment https://t.co/8uX7Db7QdB
Dr. John Cush
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Eight Survival skills (from NPR article) to manage stress: 1) identify one positive event each day.2) Tell someone or share that positive event. 3) Start a daily gratitude journal. 4) Whats your personal strength and how have you used it; https://t.co/8uX7Db7QdB
Dr. John Cush
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Study of 281 Italian pts with temporal artery Bx-proven Giant cell arteritis shows increased mortality w/ large vessel involvement (HR 5.14) at diagnosis, and reduced mortality with PMR onset (HR 0.57) & adventitial inflammation (HR 0.31) on TABx. https://t.co/iF90cqYtqn
Dr. John Cush
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Recent Methotrexate use lowers Cardivascular risk by 20% finds a Study of 23,994 elderly RA patients. 13.7% had a CVE (28.5 events per 1000 PY; 95% CI 27.6–29.5). https://t.co/yyR5DUTfF8
