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Chronic MSK Pain and Earlier Retirement

d Jack Cush, MD

Frequent musculoskeletal pain is linked with an increased risk of exiting work and retiring earlier, according to a new study published in the journal PLOS ONE.

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Infection and Rituximab-linked Immunoglobulin Deficiency

d Jack Cush, MD

A minority of immune-mediated inflammatory disease (IMID) patients treated with rituximab (RTX) are expected to develop and depressed immunoglobulin (Ig) levels.  A recent cohort analysis suggests that RTX-induced Ig deficiency was not associated with an increased risk of severe infecti

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Washington Post: Case of Delayed Rheum Diagnosis

d Jack Cush, MD

The Washington Post recently published a "medical mystery" case titled, "Medical Mysteries: A rolled ankle set this runner down a painful path", which tells the tale of how and why rheumatologists are often not consulted or are consulted too late.

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Top 10 Pharma R&D Budgets in 2023

d Jack Cush, MD

Pharma budgets have undergone significant changes coming out of COVID. This year Merck & Co. has knocked Roche from previous years of leading in research and development (R&D) budgets and investments.

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Insights on Postinfectious ME/CFS

d Jack Cush, MD

The medical community is challenged by myalgic encephalomyelitis/chronic fatigue syndrome, or ME/CFS - its origins, pathogenesis outcomes and treatment.  JAMA has reviewed a recent Nature paper wherein an NIH led team of multidisciplinary experts performed an inpatient study of postinfe

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We're gearing up for Tuesday Night Rheumatology all April long. Register today! Our first TNR takes place 4/2 at 6:30pm ET and will focus on Success in Rheumatoid Arthritis. https://t.co/TTMK07Bf7u https://t.co/lSxmfXI4sD

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Dr. John Cush RheumNow ( View Tweet)
Top 10 Pharma R&D Budgets in 2023 Pharma budgets have undergone significant changes since COVID. This year Merck & Co. has knocked Roche from previous years of leading in R&D budgets and investments. https://t.co/xx0eKgXaiQ https://t.co/tMrFlatoMk

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Dr. John Cush RheumNow ( View Tweet)
Insights on Postinfectious ME/CFS JAMA has reviewed a recent Nature paper wherein an NIH led team of multidisciplinary experts performed an inpatient study of postinfectious ME/CFS patients. https://t.co/3NiJCqZVy0 https://t.co/GAoBW9U1DW

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Dr. John Cush RheumNow ( View Tweet)
91 #SLE pts w/ no baseline synovitis, underwent Ultrasound exams. 10 yrs later, 31 had clinical progression of arthritis. Pts w/ progression, 75% had baseline subclinical synovitis on US vs without progression 77% did NOT have an abnormal US at baseline https://t.co/MN9wkNgsQV https://t.co/ozgvjFI531

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Dr. John Cush RheumNow ( View Tweet)
Biden signs executive order on womens health research ($200 million to NIH interdisc. women res), focus on: - integrate Women’s Health Across Federal Research prgs - fund Research on Women’s Midlife Health - double funding Office Womens Health Research https://t.co/NKtI5iFKeb https://t.co/G5T0YEdEkO

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Dr. John Cush RheumNow ( View Tweet)
Ides of March (3.15.2024) Dr. Jack Cush has advice for Caesar and the superstitious, and covers pregnancy, platelets, dialysis and vaccinations in Lupus. https://t.co/s87j9fXQNA https://t.co/QNDXweNAvp

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Dr. John Cush RheumNow ( View Tweet)
4873 gout pts w/ High SUA renally typed: UA overproduct. (ROA 9%); underexcreter (RUE 61%); combined (23%) or normal (7%) ROL: older, lower SUA, tophi & DM RUE: lower BMI, No DM Combined: younger, HighBMI/SUA/eGFR & smoking Normal: older, Low SUA/eGFR https://t.co/9u0Lujlkqf https://t.co/gVOvwd54Z1

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Dr. John Cush RheumNow ( View Tweet)
UAB study shows the US adult rheumatology workforce grew clinically active adult rheumatology workforce grew 23% betw 2009-2020; including a 43% increase in women. Number of Rheums (5,667) grew 23% and APPs (379) grew 141%. https://t.co/sVPoNIUZUu https://t.co/4myGYaUtcd

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Dr. John Cush RheumNow ( View Tweet)
US Trends in RA DMARD Use 2017-2021 A trend analysis of disease-modifying anti-rheumatic drugs (DMARDs) shows that only half of rheumatoid arthritis (RA) patients are taking DMARDs, and that the COVID-19 pandemic substantially affected DMARD use. https://t.co/vQmVyAjIaL https://t.co/tSJ4H5XtnU

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Dr. John Cush RheumNow ( View Tweet)
MMWR: Vaccination and Multisystem Inflammatory Syndrome in Children MIS-C is a rare but serious condition typically occurring 2–6 weeks after SARS-CoV-2 infection and characterized by fever and multiorgan involvement. https://t.co/PN2MPQxqSR https://t.co/eIzB4pjner

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Dr. John Cush RheumNow ( View Tweet)
In RA, NO selective response with Seropositivity. Study of 28 eligible RCTs shows pts Rx w/ cs- or bDMARD that seropositivity did not predict better bDMARD response (ACR20 RRR ~1). Comparable resp in RF+ & RF- w/ TNFi or non-TNFi bDMARDs. https://t.co/AUWPgkzayt https://t.co/om9AYhNsQ9

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Dr. John Cush RheumNow ( View Tweet)
9 Facts about Leflunomide Medscape has published an informative review of leflunomide, drawn from Dr. Eric Ruderman’s recent lecture on the subject at the February RWCS meeting in Maui. https://t.co/X9lyrOs3D7 https://t.co/TGh2LnGdJ8

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Dr. John Cush RheumNow ( View Tweet)
Retro study 109 oligoarticular JIA pts (~8 yrs) Rx w/ intraarticular steroids w/ 4.3 yrs F/U: 38% needed no Rx, 15.5% needed more IAS; 46% systemic Rx(MTX; 8 mos) &22% biologics(2.2 yrs later). @FUV 89% were inactive. Persistence predicted by ANA+ & B27+ https://t.co/5YLkYyA84l https://t.co/wClhEiKOIw

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Dr. John Cush RheumNow ( View Tweet)
Japanese study of 672 autoimmune pts on TNFi & tocilizumab - 1.6% (n=9) developed non-tuberculous Mycobacteria (NTM) infx post biologics. 2 disseminated NTM, 2 died. NTM pts had higher mortality [(22% vs 2.6%) & took more steroid (17 vs 3 mg, P=0.004).https://t.co/fGGafrTeiL https://t.co/DkmiC2hVEA

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Dr. John Cush RheumNow ( View Tweet)
JAMA Review of DMARD Use in Rheumatoid Arthritis JAMA has reviewed the "2022 EULAR Recommendations for the Management of Rheumatoid Arthritis With Synthetic and Biological Disease-Modifying Antirheumatic Drugs". https://t.co/fpAigPpKzv https://t.co/GkbqW2BxpA

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Dr. John Cush RheumNow ( View Tweet)

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