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Could Weight-Loss Drug Improve Hip Replacement Outcomes?
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MedPage Today
The antidiabetic and weight-loss drug semaglutide (Ozempic, Wegovy, Rybelsus) either does or does not help patients undergoing total hip arthroplasty (THA) avoid complications and other poor outcomes, according to two retrospective studies presented here.
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What are the Early Stages of Lupus?
Incomplete lupus? Undifferentiated connective tissue disease? Pre-clinical autoimmune disease? During the lupus pod at RheumNow Live 2024, Dr. David Karp discussed the spectrum of autoimmune disease and the confusing terminology that is used with the complex world of early autoimmune disease. He cautioned against the traditional use of phrases such as incomplete lupus or undifferentiated connective tissue disease, which are heterogeneous and poorly defined.
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Dr. Anisha Dua at #RWCS24 lecturing on vasculitis mimics https://t.co/Bo31icqn7S
Dr. John Cush RheumNow ( View Tweet)
Catastrophic APL has high mortality.. Use of triple Rx w pulse steroids, IV heparin and plasma exchange still only has 50% survival. #RWCS24 https://t.co/ycttHcpmjL
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Congratulations to Dr. Megan Clowse - named the new chief of the Division of Rheumatology and Immunology at Duke University School of Medicine, Durham, N.C. !! @clowse https://t.co/d6iCEHlF3F
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Obesity increase risk of psoriasis
Obesity increase risk of PsA in psoriasis pts RWCS24 https://t.co/Wt9h0QLbKH
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Obesity is assoc w higher CRP.
Losing weight lowers CRP RWCS24 https://t.co/Gc6TKtmOgI
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Higher adipose in RA linked to atherosclerosis but protects against erosions RWCS24 https://t.co/qsFMhj4LyZ
Dr. John Cush RheumNow ( View Tweet)
Dr Jon Giles at #RWCS24 shows adipose tissue produces pro inflammatory ytokines https://t.co/8NMAWIODuQ
Dr. John Cush RheumNow ( View Tweet)
Co-management of Psoriatic Disease
It is a common clinical scenario to see someone with both severe psoriatic arthritis and skin psoriasis. Co-management with dermatology optimises the care of this patient group.
https://t.co/8xZ9ZBpa3O https://t.co/xMYLhxA1j1
Dr. John Cush RheumNow ( View Tweet)
RWCS 2024 is Kicked off by Dr Artie Kavaugh in Maui. Watch for tweets from #RWCS24 #ValentinesDay https://t.co/iPKIfXphrx
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NJ leads on prior authorization legislation:
- Prior auth turnaround time is 24 hrs urgent requests
- Peer-to-peers for denials involves same specialty MD
- Transparency: companies have to share data on denials/reasons.
(29 states w/ active bills/reforms) https://t.co/pZlyW68DDL https://t.co/uc251qj2Gf
Dr. John Cush RheumNow ( View Tweet)
JAKi Safety and Efficacy in bDMARD-IR Patients With RA
This ACR 2023 poster shows SELECT-CHOICE outcomes through Week 204 from bDMARD-IR patients with RA, including TNFi-IR subgroup outcomes.
Sponsored by AbbVie US Medical Affairs. https://t.co/3fJsZ4IMjG https://t.co/xaKlZPmDkC
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Tonix is developing a drug, TNX-102 SL, that targets poor sleep quality for fibromyalgia. Phase 3 trial in FM (457 pts) showed TNX-102 SL was better (vs PBO) & improved sleep quality (p=0.0000001 & improved daily pain (p=0.00005) https://t.co/QpgET61Vec https://t.co/zphVycL3rg
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Taiwan National Health claims data looked at drugs & gout flares. Signif increase flares were seen w/ ASA, thiazides, loop diuretics, ethambutol, pyrazinamide (1.15-3.35) & metformin (SR=1.14). Lower risk w/ fenofibrate (SR=0.60) & losartan (0.92) https://t.co/1RUw1Q2EBz https://t.co/D2E68kuuwN
Dr. John Cush RheumNow ( View Tweet)
Microbiome study (stool- & saliva) in 144 DMARD-naïve RA pts. Samples 6 wks after DMARD Rx. In those achieving MCID, stool microbes decreased (Prevotella, Streptococcus). Baseline microbiota in DMARD-naïve pts indicated future response https://t.co/PQJEp3bNBE https://t.co/jV5SeNd21z
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85 Chinese SLE pts study of Dz activity & depression/ anxiety assessed by PHQ-9 & GAD-7. Good correlation betw SLEDAI-2K & SLE-DAS (r=0.76);also w/ mod-high activity (r=0.79), but less w/ mild Dz/remission (r=0.45). Anxiety/Depresion did not affect scores https://t.co/eyhgiYxf3P https://t.co/5LHg3HO21v
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Retro study of 1,169 pts (age 66 yrs) receiving intra-articular steroids & changes on A1C. A1C increases were assoc w/ higher baseline A1C (OR 1.84) for A1C 7–8 (vs <7%) or A1C >8% (OR 4.8 ). YET most patients do not experience increase A1C after IACS https://t.co/t3OWYeT1gr https://t.co/qi5qIUZQdZ
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14d study of 30 #RA pts collected data from iPhone + Apple smartwatch +PROs showed that AI analysis of sensor data augmented PRO data (by 10%) regarding RA status & severity. Sensor + PRO correlated well w/ RAPID3 status (r2, 0.692) https://t.co/3izpHiqRHG https://t.co/vMvtqOZCjF
Dr. John Cush RheumNow ( View Tweet)
VITAL Info on Autoimmune Disease
Dr. Jack Cush reviews the journal reports from the past week on https://t.co/V10S4oVFsv. Highlights are summarized by three songs: "Stairway to Heaven", "You're No Good", and "How Long (has this been going on)".
https://t.co/2553GYCfui https://t.co/y1seBTYk5u
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