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Psoriatic Pregnancies Pose Risks to the Mother, Not Child

d Jack Cush, MD

A metanalysis of pregnancy outcomes in women with psoriasis and psoriatic arthritis finds an excess risk of adverse maternal events, but not adverse neonatal events.



This systematic review included 16 studies meeting inclusion criteria. 

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Analysis of Taiwans National Health Insurance Database, shows from 4.5 children (<18yrs), 23% received steroid burst < 14 days (URI, allergies, asthma) and shows higher 30 rates of GI Bleed (IRR 1.4), Sepsis (2.02), & pneumonia (2.19) https://t.co/ReuNP1C8ww

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Dr. John Cush RheumNow ( View Tweet)

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RheumNow Podcast – Coconspirators: RA and Lung Disease

d Jack Cush, MD

Dr. Jack Cush reviews and discusses more than a dozen news and journal articles from the past week on RheumNow.com.

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Study of 207 Pediatric pts treated w/ Rituxan (for Rheum, Cancer, CNS, Renal dz) and 40% developed hypogammaglobulinemia post-RTX; hypo-IgG Pre-RTX 28.7% to Post RTX 42.6%, p=0.009; low IgG levels had higher risk of serious infx (OR 2.3) https://t.co/b91rPYgVV2

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Dr. John Cush RheumNow ( View Tweet)

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Autoimmune Risk of Death Up during COVID

d Jack Cush, MD

A population-based study in the UK shows that patients with rare autoimmune rheumatic diseases (RAIRD) were 44% more likely to die during the 2020 COVID-19 pandemic (March - April) compared to either the general population or their pre-COVID risk.

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RheumNow Podcast – Upadacitinib Wins in PsA (4.2.2021)

d Jack Cush, MD

Dr Jack Cush reviews the news and Journal reports and takes "Back Talk" questions from viewers.

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In the UK, NICE has recommended Kineret (anakinra) for use as 1st line biologic Rx in systemic JIA and adult-onset still’s disease (AOSD); but pts must first fail a DMARD - the latter is unfortunate as systemic Sxs of Still's do not respond to usual DMARDs.https://t.co/BNdqhLy9jg

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Dr. John Cush RheumNow ( View Tweet)

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Hypertension Unaffected by Urate Lowering Therapy

d Jack Cush, MD

Does uric acid contribute to the risk of hypertension (HTN)?  A recent cohort trial shows that allopurinol in young adults does not sufficiently lower blood pressure (BP).

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RheumNow Podcast – Great Associations (3.19.2021)

d Jack Cush, MD

Dr. Jack Cush rants on the journal reports, news and FDA actions featured this past week on RheumNow.com.

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Apremilast Equals MTX in Palmoplantar Psoriasis

d Jack Cush, MD

Palmoplantar psoriasis (PPP) is a therapeutically challenging variant of psoriasis; nonetheless, a prospective, randomized, active-controlled trial from India suggests that apremilast is effective and safe in patients with PPP.

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MDA-5 Antibodies and Juvenile Dermatomyositis

d Jack Cush, MD

A multicentre, retrospective study examined MSA profiles (by immunoprecipitation) from 96 juvenile idiopathic inflammatory myopathies (JIIM) at nine pediatric rheumatology centres in Japan. MSA were found in 85 of 96 cases with over 90% of patients having one of the following three MSA

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Analysis of 8416 pts w/ Kawasaki disease (KD) shows older and younger children differ. <10% were under 6 mos, 78%) were 6 mos-4yrs; 11% 5 to 9 yrs. Younger KD had more incomplete KD, coronary aneurysms, while older had more delayed diagnoses, more fever https://t.co/NkSmfg38ru

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Dr. John Cush RheumNow ( View Tweet)

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Higher Lupus Mortality Among Minority Populations

d Jack Cush, MD

The February 19th MMWR reports that higher mortality rates in certain patients with systemic lupus erythematosus (SLE); data based on recent San Francisco County statistics showing a four fold higher mortality among Asian and Hispanic/Latina females with SLE.

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Very high levels of IL-18 IL-18 (> 10 000 pg/ml) is associated with Macrophage Activation syndrome (with systemic JIA) as well as primary and secondary Hemophagocytic lymphohistiocytosis (HLH) https://t.co/dotoaYbuPd

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Dr. John Cush RheumNow ( View Tweet)

Common mucocutaneous findings in 35 kids w/ MIS-C & COVID: 1) conjunctival injection (21), palmoplantar erythema (18), lip hyperemia (17), periorbital erythema/edema (7), strawberry tongue (8), & malar erythema (6) https://t.co/mcSOXtXaEh

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Dr. John Cush RheumNow ( View Tweet)

1975: Nixon & Bresnev, in effort of medical diplomacy, cooperated on JRA trials. (Fact: Stalin's personal physician was a rheumatologist.) Dr. Steven's shares an interesting historical slide about this collaboration. #RWCS2021 #RWCS @RWCSmtg @RheumNow https://t.co/Px71qfqDcy
Dr. Rachel Tate uptoTate ( View Tweet)
Some statistics regarding pediatric rheumatologists in the US and abroad. Here in the US we have under 30 fellowship options, 448 pediatric rheumatologists in 2019 (and growing), and patients/families are driving on ave 42.8 miles to get care. #RWCS2021 #RWCS @RheumNow @RWCSmtg https://t.co/RhTroEKcwN
Dr. Rachel Tate uptoTate ( View Tweet)
A serious shortage of pediatric rheumatologists in the USA, where we need at least 1 ped rheum per 400,000 population. @RWCSmtg https://t.co/o8XCkjUOaN
Dr. John Cush RheumNow ( View Tweet)
CARRA was established in 2000 to further pediatric Rheumatology through research and registries @RWCSmtg https://t.co/drXGz23QyN
Dr. John Cush RheumNow ( View Tweet)
Milestone achievements of the pediatric Rheumatology collaborative study group @RWCSmtg https://t.co/OGXd2YWj5A
Dr. John Cush RheumNow ( View Tweet)

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