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EULAR 2021 – Day 1 Report
After the opening ceremonies and keynote speaker there were several enticing sessions and a plenary session full of great research and presentations. Here are a few of the highlights that I saw.
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Can machine learning show JAKi effects for safety? Off target binding predicted in #tofacitinib 58, #baricitinib 41 but NO pathway for thrombosis or viral infection. Could have repurposing for + effects on lung vasculature & antifibrotic effects POS0091 #EULAR2021 @RheumNow
Janet Pope Janetbirdope ( View Tweet)
MACE events with #JAKi is as clear as mud! You voted >50% NOT Sure 1/3 only some Jakis vs MACE in #TNFi! Dunno #EULAR2021 @RheumNow @eular_org https://t.co/vWUgKSwAap
Janet Pope Janetbirdope ( View Tweet)
AVN in SLE is ⬇️ing over time! risks are same: younger, male, glucocorticoids & also found hyperlipidemia. ?due to older age of onset & less steroids over time & better immune suppressants POS0730 @RheumNow #EULAR2021 @eular_org https://t.co/IG3NVrZl4D
Janet Pope Janetbirdope ( View Tweet)
Once approved, what type of patients with #SLE would you treat with #anifrolumab? #EULAR2021 #OP0131 @RheumNow
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Do we need to monitor #ECG in patients on #HCQ and #polypharmacy? Dr Antivalle reported ⬆️QTc interval in HCQ vs controls. Only 3/132 was above ULN in HCQ group though. Importantly,⬆️QTc was noted more in HCQ + co-meds (e.g. PPI) #EULAR2021 #POS0090 @RheumNow https://t.co/1Ui4MghqIk
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Don’t forget to use imaging that you already have!
CT Abd/Pelvis (ordered for nonMSK) of 301 IBD pts shows underlying sacroilitis
⭐️60/301 had sacroilitis on CT
⭐️11/60 had AxSpA
⭐️3/60 previously undiagnosed axSpA
Abs#POS0035
#EULAR2021 @RheumNow
Robert B Chao, MD doctorRBC ( View Tweet)
Bingo. It always had been rather odd to me that you would call someone nr-SpA when they had MR evidence of disease; xrays are not sensitive to pick up changes. While we're at it, can we just use the term "imaging" instead of "radiographs" with the availability of better tech? https://t.co/I6reoHyywf
k dao KDAO2011 ( View Tweet)
Fatigue 35-80% of rheumatic pts! Excellent talk on fatigue in arthritis, SpA and systemic rheumatic disease! Abs#OP6875 #EULAR2021 @RheumNow
How do you help pts manage fatigue?
Robert B Chao, MD doctorRBC ( View Tweet)
What's your EULAR IQ? #EULAR2021
https://t.co/psumBpzUc7 https://t.co/ZyD87VY8u6
Links:
Dr. John Cush RheumNow ( View Tweet)
#EULAR2021 - Day 1 Podcasts
Check out this compilation of our EULAR 2021 Day 1 broadcasts .
You can follow the EULAR 2021 RheumNow podcasts on iTunes and Soundcloud.
https://t.co/p6n7BTsK5C https://t.co/I36SMGlb2o
Links:
Dr. John Cush RheumNow ( View Tweet)
Leave my MTX alone says pt & #rheumatologist if pt has chronic ILD. Acute pneumonia from MTX is NOT chronic ILD in RA @RheumNow @eular_org #EULAR2021 #BoehringerIngelheim RA ILD silent killer symposium https://t.co/IQTINuUpVq
Janet Pope Janetbirdope ( View Tweet)
Check out our psoriatic arthritis coverage from #EULAR2021. Head to RheumNow for full EULAR coverage.
https://t.co/NzB2e2Vfwb
Links:
Dr. John Cush RheumNow ( View Tweet)
What about musculoskeletal #pain in PsO patients? Results of a nationwide Danish survey #POS0149 that shed light into unadressed reduced quality of life and risk to move towards #PsA #EULAR2021 @RheumNow https://t.co/JQnHSvtpHm
Paul Studenic Stiddyo ( View Tweet)
OP0186 #EULAR2021 by Dr. Mariele Gatto.
Anti-cancer effect of immunotherapy with ICI is believed to be mediated by CD8 positive Tc cells.
It is not known if other cells get activated. This study looks at B cells.
Transitional B cells ⬆️ in ICI induced arthritis (CP-IA).
/TK https://t.co/szFF81SKVL
ARD & RMD Open ARD_BMJ ( View Tweet)
No requirement to stop cDMARDs before surgery. For biologics stop 1 dose before and restart 14 days post op, JAKi stop 7 days before, restart 14 days post op, glucocorticoids >10mg/day increases risk of infection in #rheumatoidarthritis Michael D George #EULAR2021
Dr. Antoni Chan synovialjoints ( View Tweet)
So how do irAEs work?
Dr. Anne Bass @lovetolearn27 @HSpecialSurgery gives #EULAR2021 a possible conceptual framework
@LCalabreseDO @CCalabreseDO @cappelliMD @got_rheum @MarieKostine and so many other good people! @RheumNow https://t.co/5eOZDwkGO6
David Liew drdavidliew ( View Tweet)
⬆️prevalence of HCQ retinopathy: Kaiser Permanente 676 pts retrospect study #OP0133
👉6.8% (n=46) had HCQ retinopathy w/ risks:
👉age>80 (OR 3.83)
👉h/o atherosclerosis (OR 2.99),
👉cum. dose >2000 mg (OR 15.8)
👉10-15 yrs use (OR 4.44)
👉>15 yrs (OR 19)
#EULAR2021 @rheumnow https://t.co/QA8HHXdnjL
k dao KDAO2011 ( View Tweet)
News: Featured Abstracts from Industry at EULAR 2021
https://t.co/hIBYUdHTLf https://t.co/LTTJ3WPl7X
Links:
Dr. John Cush RheumNow ( View Tweet)
Honoured to be part of the irAE session at #EULAR2021, with some great talks (and then also mine), including:
- Anne Bass @lovetolearn27 @HSpecialSurgery on irAE mechanisms
- Maria Suarez-Almazor @MDAndersonNews on irAEs in the clinic
Well worth tuning into! @RheumNow https://t.co/MN1IcLKv6u
David Liew drdavidliew ( View Tweet)
