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Prevalence of Cardiovascular Disease in Rheumatoid Arthritis
A prospective study of the BioSTAR registry estimates the prevalence of cardiovascular disease in rheumatoid arthritis (RA) to be 4.6%.
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Best Treatments for COVID-Related MIS-C
The RECOVERY trial focused on pediatric MIS-C patients treated with immunomodulators and anti-cytokine therapy demonstrated the benefits of first-line therapy with intravenous methylprednisolone or second-line tocilizumab in children refractory to initial treatment.
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New therapeutic approach for the treatment of sarcoidosis
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Eureka Alert!
A research team led by Georg Stary (Medical University of Vienna and CeMM) has identified a new approach to treating the inflammatory disease sarcoidosis. In a clinical study, the inhibition of a specific signaling pathway showed clear success in the treatment of granulomas in the skin. This opens up new therapeutic paths for sarcoidosis and similar inflammatory diseases. The results were recently published in the journal Lancet Rheumatology.
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Study of 235 newly Dx #RA patients (157 females) found that 11 pts (5%) had carpal tunnel syndrom (CTS) at the time of initial RA diagnosis. Such pts were more likey to be older, female, CCP negative and have a longer Sx duration. https://t.co/0CfF0lKBgk https://t.co/tx9CvQ4TWX
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No evidence of harm starting urate lowering Tx (ULT) during #gout attack. Metanalysis 6 RCTs (445 pts) w/ gout attacks given ULT vs PBO or delayed ULT. No differences in pain, time to resolve gout flare or risk of recurrent gout flare in 30d (RR 1.06) https://t.co/xUX2U6MmGP https://t.co/2bV0g2FOSK
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Meta-analysis of 35 RCTs (>20K pts) with inflammatory skin disorders shows that w/ short-term (<5 mos) use JAK inhibitors do not significantly increase risk of all-cause mortality (OR, 0.83; 0.44-1.57), MACE, or VTE (OR, 0.52; 0.26-1.04). https://t.co/zBlcZ02QqQ https://t.co/cXjswVS9lF
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Microbiome study of 16 SLE pts (44 fecal samples) shows that blooms of Ruminococcus gnavus pathobiont was assoc w/ lupus flares and may be the drivers of clinical of relapsing lupus disease https://t.co/OXA4L6kG4p https://t.co/zXX7ZfWik1
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2019 NHIS chronic pain study shows signif disparity in nonpharmacologic & integrative medicine (IHM) use by populations. More IHM with city living, higher income & education, widespread pains. Less IHM w/ elderly, males, Blacks, opioid use, depression https://t.co/uoOyQBXTmy https://t.co/yTTVc5zljG
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Join us this weekend! More than 25 sessions on topics ranging from spondyloarthritis, PsA, vasculitis and lupus to JAK inhibitors, RA, artificial intelligence and myositis. CME and MOC offered. Learn more about our program and registration options today!
https://t.co/6uWDDIUnvA https://t.co/aWk4IKZYC4
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ACR Applauds Prior Authorization Rule
The ACR applauds the CMS for finalizing its Advancing Interoperability and Improving Prior Authorization Processes for Medicare Advantage Organizations rule recently.
https://t.co/ZVPl2bUT3g https://t.co/ynynH0A8XN
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Severe Hypocalcemia Risk w/Denosumab and CKD Patients
On 1/19 the FDA issued a Drug Safety Communication about the risk of severe hypocalcemia in CKD patients taking denosumab for osteoporosis.
https://t.co/VPpIZBZQkm https://t.co/yxFYn1ob5A
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What do you know about monogenic and polygenic autoinflammatory diseases? Join Drs Liebowitz and Mehta as they review the challenges of these conditions. https://t.co/z0mTZEwFkP https://t.co/LAxl2eFZKR
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QD Clinic - RA, SSZ, & MI
RA with a myocardial inflarction - which DMARD?
https://t.co/9o83xedJ3j https://t.co/P5jmZAZ9rt
Dr. John Cush RheumNow ( View Tweet)
Join us this weekend! More than 25 sessions on topics ranging from spondyloarthritis, PsA, vasculitis and lupus to JAK inhibitors, RA, artificial intelligence and myositis. CME and MOC offered. Learn more about our program and registration options today!
https://t.co/Iac2T2Kohs https://t.co/zu1WJLOcmh
Links:
Dr. John Cush RheumNow ( View Tweet)
Methotrexate Nodulosis
How good (or not) are rheumatologists and what to do about MTX nodulosis?
https://t.co/Ot9UfpH68N https://t.co/JQ2AtuE7NV
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11-yr French study of #RA Pregnancies: more adverse Preg outcomes in RA, esp w/ active Dz. 11.8K RA vs 10.4 million non-RA Pregs. 75% live births in RA. RA had more preterm(aOR 1.84), low birth wt (1.65), C-Sect (1.46), hospz (1.30), & prematurity (2.02)https://t.co/v9CmiPkIBG https://t.co/S0siiuG0oZ
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Mexico survey of 250 RA pts -- 92% used complementary (CAM) therapies - mostly: herbals (65%), homeopathy (64%), cannabis derivatives (51%). Poor DMARD adherence assoc w/ age (p=0.019), comorbidities (p=0.047), CAM use (p = 0.042) (OR 2.84) https://t.co/EGxyIVCMnk https://t.co/jjF5cH53we
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FDA Safety Warning: denosumab now has a Boxed Warning for risk of severe hypocalcemia in CKD pts taking Prolia (usually seen 2-10 wks post injx). Pts may or may not be symptomatic. CKD pts should have Ca and Creatinine monitored. https://t.co/tGiG35cOnv https://t.co/ITOZneGKtb
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Rheumatologists and the Early Diagnosis of Spondyloarthritis
SPACE study of adults referred to rheumatology with less than 2 years of chronic back pain (CBP), shows that only one-third can be reliably diagnosed with axial spondyloarthritis (axSpA).
https://t.co/EwrrunyZs7. https://t.co/T0OqlsuU2P
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Rheumatologists: What is your preferred MOA/Drug in treating Psoriatic Arthritis?
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