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SLE: A Mutated Gene and TLR7 Overexpression
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EurekAlert!
A group of researchers lead by Min Ae Lee-Kirsch from the Department of Pediatrics, Medical Faculty, TUD Dresden University of Technology (Germany), studied four patients from two families who developed symptoms of SLE in the first years of life.
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2023 Rheumatology Year in Review
Dr. Jack Cush reviews highlights, advances and hot topics in rheumatology from 2023 and the RheumNow website.
2023 was a year of growth and new horizons while returning to operational and practice standards (in care and education) established before the pandemic.
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Increased CV Comorbidity in Dermatomyositis
A cohort study suggest that patients with dermatomyositis (DM) are at an increased risk for multiple comorbidities, including chronic kidney and cardiovascular disease,
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Drug-Induced Dermatomyositis
A JAMA Dermatology systematic review of drug-induced dermatomyositis (DM) found the most commonly implicated agents include hydroxyurea, immune checkpoint inhibitors, statins and lipid-lowering agents, penicillamine, and tumor necrosis factor inhibitors.
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Heritability of Osteoarthritis
A Swedish study examine the genetic contribution to various rheumatic/musculoskeletal diseases (RMDs) and showed that osteoarthritis (OA) had a large heritability compared with other RMDs.
https://t.co/KbQDQ1mB53 https://t.co/opLrlRit2W
Dr. John Cush RheumNow ( View Tweet)
Bidirectional relationship betw Autoimmune disease (AD) & perinatal depression (PND); 1:10 case control study of 1.3 milion pregnancies & 55,299 incident PND found AD preg w/ a 30% (OR 1.3) higher risk of PND & PND had a 30% ^ risk (OR 1.3) of AD https://t.co/zkwIo6liC7 https://t.co/Sy1HPLLeva
Dr. John Cush RheumNow ( View Tweet)
Experience the Future of Rheumatology at RheumNow Live 2024, just two weeks away!
Don't miss out – secure your spot today for an unforgettable journey into the latest advancements and insights.
https://t.co/bbnb97MOHO https://t.co/QXO34ZmP2i
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Dr. John Cush RheumNow ( View Tweet)
QD Clinic - ANA Positivity in RA
Considering an ANA+ Seropositive RA Patient
https://t.co/q0g0JsSWGu https://t.co/nXcEZbbEXG
Dr. John Cush RheumNow ( View Tweet)
Enthesitis, Synovitis, and Tenosynovitis in Psoriatic Arthritis
An ultrasound study suggests that enthesitis is associated with both synovitis and tenosynovitis in patients with Psoriatic arthritis (PsA).
https://t.co/c9z0nsABe0 https://t.co/Ez4i8qCcJ8
Dr. John Cush RheumNow ( View Tweet)
Curcumin therapy for knee osteoarthritis
Curcumin is widely used in traditional Chinese medicine to treat arthritis and is presumed to have analgesic and antiinflammatory effects that may benefit those with osteoarthritis, particularly KOA.
https://t.co/a8JscOOhmz https://t.co/j1htFQkfnD
Dr. John Cush RheumNow ( View Tweet)
Hydroxychloroquine Overview (full read)
History, PK/PD, MOA, Clinical Benefits, dosing, Adverse events covered.
https://t.co/oJcM5ewOBh https://t.co/UaUiH7rpfM
Dr. John Cush RheumNow ( View Tweet)
2023 Rheumatology Year in Review
Check out my top 10 list (in no particular order) of 2023 advances, game-changers, and developments that changed, or will soon change, rheumatologic practices.
https://t.co/UaaAd8pcpM https://t.co/8EIkMeunyZ
Dr. John Cush RheumNow ( View Tweet)
Hormonal Status Increases RA Risk
Early menopause—before the age of 45—taking hormone replacement therapy (HRT), and having 4 or more children are among several hormonal and reproductive factors linked to a heightened risk of RA in women.
https://t.co/Rz6rzkOHV5 https://t.co/UYjgs0MBv5
Dr. John Cush RheumNow ( View Tweet)
Full read review of Catastrophic Antiphospholipid Syndrome (CAPS) https://t.co/J1kOJYv1Cl https://t.co/cJQagQmEp6
Dr. John Cush RheumNow ( View Tweet)
Retrospective study 127 suspected #GCA w/ negative temporal artery Bx - 73 finally Dx w/ GCA & 61/73 were FDG PET-CT pos.(84%). In 54 nonGCA, FDG PET-CT was positive in 8 (15%). FDG-PET sensitivity 84% (100% extracranial LV-GCA), specificity of 85%. https://t.co/Uc8dbdzIil https://t.co/z2d7h6jCFP
Dr. John Cush RheumNow ( View Tweet)
Insurance claims data compared 33k RA to 1079 PM/DM pts and showed overall lower use of statin R in PM/DM (27% vs 181%, p<0.0001). But if DM/PM-HLD pts used statins they had lower mortality rate than non-users (HR = 0.515, p = 0.0273) https://t.co/El0mmNZ8ZR https://t.co/428YmGlV5k
Dr. John Cush RheumNow ( View Tweet)
Real-world data of 5070 RA pts (1816 Rx w/ b/tsDMARDs) showed the use of tsDMARD considerably increased from 2012 to 2021. All b/tsDMARDs pts improved Dz activity & function/ 10 yr effiicacy best for IL6Ri in switch pts and ABA in bNAIVE pts https://t.co/H4Ohe12LrV https://t.co/viUdiZvxVa
Dr. John Cush RheumNow ( View Tweet)
Metanlysis of 49 studies, 10 RCTs examined the relationship between RA and non-surgical Rx of periodontitis (NSRT) and in general short term studies show that NSPT benefits RA patients; and DMARD therapy benefits periodontitis https://t.co/ApKUipFzYn https://t.co/qw6SYn1tBf
Dr. John Cush RheumNow ( View Tweet)
Black, Asian, and Hispanic Military Members w/OA Treated Differently
Black, Asian, and Hispanic members of the U.S. Armed Forces were less likely than their white peers to undergo knee replacement surgeries post OA diagnosis, military researchers found.
https://t.co/Kzj4XyCmZt https://t.co/TwBAtn9Dwr
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ICYMI: When PMR Strikes Young, It Hits Hard
https://t.co/rUuPnbcgCY https://t.co/AMpqGCJhIa
Dr. John Cush RheumNow ( View Tweet)