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EULAR 2025 - Day 1 Report

Jack Cush, MD

Wednesday was Day One at EULAR 2025 in Barcelona. Thousands from around the world gathered, eager to reunite at this international educational forum. Below are a few of my favorites from Day 1.

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Secukinumab Use in Refractory Giant Cell Arteritis

Jack Cush, MD

In 2023, the phase 2 TitAIN study showed that the effectiveness and safety of secukinumab in 52 patients with giant cell arteritis (GCA) who had an inadequate response to tocilizumab.

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2025 EULAR/ACR Risk Stratification Criteria for At-Risk Arthralgia

Jack Cush, MD

A collaborative EULAR/ACR expert panel has established criteria for arthralgia patients at risk (clinically suspect arthralgia) to progress to chronic rheumatoid arthritis (RA).

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MTX Fails Knee OA (6.6.2025)

Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from this past week on RheumNow.com

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HLA-B27 Testing in Practice

Jack Cush, MD

Analysis of testing for human leukocyte antigen B27 (HLA-B27) in a teaching center shows HLA-B27 testing was frequently performed by rheumatologists and nonrheumatologists for a broad spectrum of indications and primarily as a screening test. 

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Autoimmunity Rising in Expectant Mothers

Jack Cush, MD

Lancet Rheumatology has published a UK study showing a significant increased in the number of expectant mothers beginning their pregnancies with autoimmune conditions.

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Denosumab and Osteoporosis - A JAMA Review

Jack Cush, MD

An overview of denosumab use in osteoporosis (OP)  by Bauer and Ensrud was published in JAMA. 

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Contemporary lupus nephritis treatment

Janet Pope, MD, MPH, FRCPC

Outcomes in lupus nephritis are akin to the glass half full. Serial monotherapy is out, as the percentage who achieved a complete renal response was very low and some went to end stage kidney disease (ESKD). Solutions?

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2025 ACR Guideline for the Treatment of SLE

Jack Cush, MD

The ACR has released its 2025 Systemic Lupus Erythematosus (SLE) treatment guidelines and consensus-based good practice statements, applicable to children and adults with SLE. 

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Got paraproteinemia? Here’s what to think about, from a rheumatology point of view. @RheumNow #EULAR2025 https://t.co/eu7Mi5yeum

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David Liew drdavidliew ( View Tweet)
HLA-B27 Testing in Practice Analysis of testing for human leukocyte antigen B27 (HLA-B27) in a teaching center shows HLA-B27 testing was frequently performed by rheumatologists and nonrheumatologists for a broad spectrum of indications and primarily as a screening test. https://t.co/IabqHyi0rl
Dr. John Cush RheumNow ( View Tweet)
Turkish study of 1263 primary care referrals to rheumatology found 35.7% with inflammatory rheumatic Dz (IRD), 17.7% osteoarthritis, and 11.2% regional pain syndromes. Another German study showed low risk of IRD if CRP <5 https://t.co/v5qYb7c7jP https://t.co/iq4NfcC3cH https://t.co/RQan6rQi8a

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Dr. John Cush RheumNow ( View Tweet)
Genetic Link to CPPD In a first-of-its-kind genome-wide association study (GWAS) researchers have discovered two genes, RNF144B and ENPP1, that cause calcium pyrophosphate deposition (CPPD) disease in Americans of European and African descent. https://t.co/YSR6rEYzjG https://t.co/L7JyoxQp3K

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Dr. John Cush RheumNow ( View Tweet)
JAMA CME review of Immune Thrombotic Thrombocytopenic Purpura (iTTP) - thrombotic microangiopathy w/ hemolytic anemia (MAHA) & thrombocytopenia. iTTP incidence is 2-6 per million. Caused by Abs to ADAMTS13), w/ low ADAMTS13 activity vWF multimers bind platelets https://t.co/kwKXUciBd1
Dr. John Cush RheumNow ( View Tweet)
Annals of Internal Medicine has published a CME review of LYME DISEASE. Most Lyme is Dx by onset of the erythema migrans rashes,. Lyme Ab testing is of low sensitivity at onset but more sensitive w/ time & CNS, CV complications. or Mono- or oligoarticular arthritis https://t.co/NfL0dabeGe
Dr. John Cush RheumNow ( View Tweet)
SLE, Antiphospholipid Antibodies, and the Placenta It is well established that women with SLE are at increased risk for adverse pregnancy outcomes, including preeclampsia, preterm birth, and pregnancy loss. However, the pathophysiologic mechanisms driving these complications https://t.co/z0BOT3xsuQ
Dr. John Cush RheumNow ( View Tweet)
Lupus in an empty house The full house immunofluorescence pattern is the classic histopathologic finding of lupus and lupus nephritis. Glomerular deposits staining for IgG, IgA, IgM, C3 and C1q can help confirm a suspected diagnosis of systemic lupus erythematosus (SLE). This https://t.co/Zcywc5r9q9
Dr. John Cush RheumNow ( View Tweet)
We are not (yet) in #SLE Getting 👇 Correct drug In right pt At right time At correct individual dose Even more problematic is in a renal bx - 2 glomeruli beside each other have v different cytokine expressions Unravelling #LUPUS2025 @RheumNow https://t.co/yGBvhFkPKY

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Janet Pope Janetbirdope ( View Tweet)
Here’s who flares in #SLE least to most Persistently neg antiDNA Persistently + antiDNA conversion of neg to + antiDNA So are we over ordering antibodies in 1st 2 groups 🤷‍♀️ Unravelling #LUPUS2025 @RheumNow https://t.co/1Feau7f199

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Janet Pope Janetbirdope ( View Tweet)
An excellent presentation from Dr Pankti Mehta @PanktiMehta24 Re #Jaccoud’s With #IFN signature if #erosive IA - often + CCP / RF Vs nonerosive often +RNP @RheumNow #LUPUS2025 https://t.co/y6z4KbhCdy

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Janet Pope Janetbirdope ( View Tweet)
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