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Can the Focus Score predict Lymphoma in Sjogren’s syndrome?

Eric Dein, MD

Patients with Sjogren’s syndrome are nearly 19 times more likely to develop lymphoma, so identifying factors that impact this risk development is a major goal in caring for this disorder.

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EULAR,Podcast,2021

EULAR 2021 - Day 2 Podcasts

Jack Cush, MD

Check out this compilation of our EULAR 2021 Day 2 broadcasts below.



You can also follow the EULAR 2021 RheumNow podcasts on iTunes and Soundcloud.com



Listen by Clicking below:

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Checkpoint Inhibitor Safety in Melanoma Patients with Autoimmune Disease

Jack Cush, MD

Immune checkpoint inhibitors (ICI) are well known to cause immune-related adverse events (irAEs). A study from the Dutch Melanoma Treatment Registry shows that the use of checkpoint inhibitors for advanced melanoma in AID (autoimmune disease) patients did not increase the risk of irAEs, except for those with preexisting IBD.

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RheumNow Podcast – Coconspirators: RA and Lung Disease

Jack Cush, MD

Dr. Jack Cush reviews and discusses more than a dozen news and journal articles from the past week on RheumNow.com.

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Low Risk of Malignancy with Secukinumab

Jack Cush, MD

Analysis of ongoing safety from the secukinumab (SEC) drug development program shows a low risk for malignancy in SEC patients treated for up to five years for either psoriasis, psoriatic arthritis (PsA) or ankylosing spondylitis (AS).

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RheumNow Podcast – Mistakes with Steroids

Jack Cush, MD

Dr Jack Cush gives his spin on this week's RheumNews and Rheum Research from RheumNow.com.

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Overview of New VEXAS Syndrome

Jack Cush, MD

Medscape offers up an informative overview of the newly described syndrome called VEXAS discovered by researchers at the National Institutes of Health.

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High Risk Cancer Profiling with Inflammatory Myositis

Jack Cush, MD

A recent metanalysis of studies suggest you may be able to use certain clinical factors to stratify cancer risk in patients with idiopathic inflammatory myopathies (IIMs).

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Checkpoint Inhibitor Use with Pre-existing Autoimmune Disease

Jack Cush, MD

Annals of Internal Medicine reports treating advanced melanoma with immune checkpoint inhibitors (ICI) in patients with pre-existing autoimmune disease (AID) was as effective and safe in those with AID compared to those without AID, although severe colitis occurred more frequently among pati

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Can Focus Score Predict Risk of Lymphoma in Sjogren's Patients? https://t.co/kBptqUx2XG https://t.co/8y1736Kj8T

Links:

Dr. John Cush RheumNow ( View Tweet)
Can the Focus Score predict Lymphoma in Sjogren’s syndrome? by Dr. Eric Dein ( @ejdein1 ) https://t.co/B5HN6ju3ru https://t.co/3MuXH66YqJ

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Dr. John Cush RheumNow ( View Tweet)
Video: RA and Cancer: Myth or Reality? Dr. Jonathan Kay ( @RheumKay ) Dr. Kay reviewed highlights from the "Oncorheumatology: the crossroads of cancer and musculoskeletal diseases" scientific session including abstract OP0187, presented at #EULAR2021. https://t.co/KaLEZ67L5S https://t.co/6MHXyffO2W

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Dr. John Cush RheumNow ( View Tweet)
#EULAR2021 POS0230: TNFi changes intestinal microbiota in IBD-SpA ⬇️ Proteobacteria ⬆️Lachnospiraceae, Coprococcus Does inflammatory changes by TNFi restore intestinal eubiosis and does this affect SpA outcomes? @Rheumnow

Eric Dein ejdein1 ( View Tweet)

⭐️All cancer excluding NMSC - 0.9HR TNFi vs cDMARD ⭐️Squamous cell CA - 1.2HR of TNFi vs cDMARD ⭐️No overall increase in all CA: RTX, TOCI ⭐️Abatacept 1.21HR for all cancer, mainly NMSC ⭐️needs more data on JAKs, IL-17, IL-23 Abs#6916 #EULAR2021 @RheumNow

Robert B Chao, MD doctorRBC ( View Tweet)

OP0186 #EULAR2021 by Dr. Mariele Gatto. Anti-cancer effect of immunotherapy with ICI is believed to be mediated by CD8 positive Tc cells. It is not known if other cells get activated. This study looks at B cells. Transitional B cells ⬆️ in ICI induced arthritis (CP-IA). /TK https://t.co/szFF81SKVL
ARD & RMD Open ARD_BMJ ( View Tweet)
Checkpoint Inhibitor Safety in Melanoma Patients with AID A study from the DMT shows that the use of checkpoint inhibitors for advanced melanoma in AID patients didn't increase the risk of irAEs, except for those with preexisting IBD. https://t.co/VFzBOlc0wc https://t.co/0zfr8YFmZr

Links:

Dr. John Cush RheumNow ( View Tweet)
Great reminder of from Dr. Kathryn Dao, @KDAO2011 from #RNL2021 Caution! Verrucous LE can simulate skin cancer! Both can be found in photosensitivity areas! #RheumNow

Dr. John Cush RheumNow ( View Tweet)

High Risk Cancer Profiling with Inflammatory Myositis A recent metanalysis of studies suggest you may be able to use certain clinical factors to stratify cancer risk in patients with idiopathic inflammatory myopathies (IIMs). https://t.co/TjmdGtdDQG https://t.co/tlfVU031fY

Links:

Dr. John Cush RheumNow ( View Tweet)
No increased risk of cancer with TNFi use in PsA patients @RWCSmtg @JointMD https://t.co/7VSI1Fd1hw
Dr. John Cush RheumNow ( View Tweet)
Danish Cohort study of 5310 cutaneous LE or SLE pts between 1995-2014 (7-8 yrs F/U and 40.724 PYs) shows an overall increased cancer risk for CLE (SIR 1.35)and SLE (1.45), esp a 3-4 fold increased risk for NHL, hematological, pancreatic and lung cancers https://t.co/0FialHXVvb

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Dr. John Cush RheumNow ( View Tweet)

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