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ACR Best Abstracts - Day 1
The RheumNow faculty reporters have been glued to their monitors all day, viewing video, reading and listening to abstract presentations and I charged them to earmark those presentations were the “Best” they saw today. Below is the list of most often noted #ACRbest abstracts from Day 1.
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Serial RF titers? Abst#0754 from Japan: Pts with RF>45, tracked RF at month 0/4/12 after starting b/tsDMARD. 46/130 had RF decrease titers, had better radiographic remission/DAS28-ESR. Limits: varied Rx, More aggressive Rx w RF decrease grp @RheumNow. #ACR20
Eric Dein ejdein1 ( View Tweet)
#ACR20 @RheumNow. We think of dichotomy of erosive vs. non-erosive but Abst#0748 shows joint space narrowing precedes erosive disease and requires more attention for early recognition. https://t.co/JLd3xVTlXM
Eric Dein ejdein1 ( View Tweet)
Will we start getting fine-specificity ACPAs to drive treatment of RA? Abst#0743 shows fs-ACPA (anti-fibrinogen B) predict greater response to ABA+MTX vs MTX alone. #ACR20 @RheumNow. Role of RA antibodies will continue to evolve and guide Rx. https://t.co/pY4mm19Jc7
Eric Dein ejdein1 ( View Tweet)
What do you think? The great debate continues... leave your thoughts in the comment section below! #ACR20 @RheumNow @LCalabreseDO @CCalabreseDO https://t.co/KwQX0XoO93
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
HCQ Not Associated with QTc Length in SLE and RA Patients: Dr. Janet Pope @Janetbirdope #ACR20
https://t.co/zPIaFIiqr5 https://t.co/Wk8YQpIpo7
Links:
Dr. John Cush RheumNow ( View Tweet)
Year in review by @JYazdanyMD ENTRACTE trial: CV safety of TCZ vs. ETN >similar CV events >TCZ grp slightly more infections & GI perforations @RheumNow #ACR20 https://t.co/yBDeHBDB3Z
sheila RHEUMarampa ( View Tweet)
Abst#0194 at #ACR20 showed that significant symptoms of depression in RA are more frequent than depression diagnosed clinically, suggesting that depression may go undiagnosed and that symptoms of depression predicted mortality in RA patients! @RheumNow https://t.co/GqwXNB45y2
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
ACPA+ and subclinical synovitis does not automatically mean developing to RA.
Interesting work by Cleo Rogier et al. Something to consider in pts w/arthralgias & when to start csDMARDs @RheumNow #ACR20 Abstr#481 #ACRbest https://t.co/q3vIITmtq2
sheila RHEUMarampa ( View Tweet)
This convinces me! #TNF inhibitors vs #JAKI
great debate at #ACR20 https://t.co/Xb8KkmDJ8f
KenWarringtonMD MdWarrington ( View Tweet)
Scoring hand x-rays for Sharp scores is painfully tedious and not always perfectly consistent.
Why not get a computer to do it? Turns out you can - a deep adaptive machine learning model does as well as a human, each x-ray in literally one second.
#ACR20 ABST0493 @RheumNow https://t.co/SvqkaFy8XZ
David Liew drdavidliew ( View Tweet)
Zonulin levels ⬆ in pre-RA/RA pts; activation of zonulin signalling leads to ⬆ intestinal permeability.
Leaky gut - potential therapeutic target for RA?
@RheumNow #ACR20 abs#492 https://t.co/C4TVrWwcYG
sheila RHEUMarampa ( View Tweet)
UK Biobank data: RA is associated with not just restrictive but also *obstructive* patterns on spirometry/PFTs (independent of smoking).
Consistent observation; direction of causality? The lung in RA continues to fascinate.
Prisco @jeffsparks et al #ACR20 ABST0491 @RheumNow https://t.co/LcjtAefnVF
David Liew drdavidliew ( View Tweet)
Methotrexate and Nonalcoholic Fatty Liver Disease: Dr Eric Dein (@ejdein1)
Dr. Eric Dein discusses the findings of abstract #0181 at the #ACR20 annual meeting.
https://t.co/TzbRRbw1Kf https://t.co/vK6EahTyQ8
Links:
Dr. John Cush RheumNow ( View Tweet)
VA Population study shows that incident RA was less common in persons w/ HIV (PWH)(matched w/ uninfected). Only 21 RA pts in 56K PWH. PWH+/RA+ have lower autoantibodies and less likely to get DMARDs. #ACR20 Abstr#0195 https://t.co/rERJVQfq7a https://t.co/g5lATtxqOM
Dr. John Cush RheumNow ( View Tweet)
Shoutout to @SattuiSEMD and @NavarroMillanMD showing #dementia is lower in #RA pts on bDMARDs compared to csDMARDs using CMS data #ACR20 ABS#0488 @RADoctor @RheumNow https://t.co/1XOV2zqKko
Bella Mehta bella_mehta ( View Tweet)
How do you treat ACPA+, subclinical synovitis (US/MRI+)? Abst#0481 reviews 3 cohorts for progression to clinical inflam arthritis. 44-68% did not progress to IA in 1 year, is DMARD over treating? #ACR20 #ACRBest @RheumNow
Eric Dein ejdein1 ( View Tweet)
Sustained remission is rare, should we settle for sustained low disease activity? Abst#0480 ESPOIR Cohort says no, get remission if possible for better radiographic (Sharp) and fxnal (HAQ) scores. Maybe perfect isn't enemy of good? @RheumNow. #ACR20 https://t.co/QNQn9n27rm
Eric Dein ejdein1 ( View Tweet)
Early RA pts may develop chronic widespread pain. Not all have fibromyalgia. Multiple areas of pain & inflammation ^ chronic pain & other factors ie women high initial pain longer symptoms @CRASCRRheum @RheumNow #ACR20 abstr#187 1/3 at onset have regional pain 1/4 at 1yr https://t.co/7qOxH4h7Dd https://t.co/IFO1uwyR0o
Janet Pope Janetbirdope ( View Tweet)
#ACR20 Basic Science Year-in-review Really important work by @danaorange showing PRIME cells can predict flares in #RheumatoidArthritis patients #HSSrheum @RheumNow
https://t.co/XTqqinAN2a https://t.co/24HkqgHS0H
Bella Mehta bella_mehta ( View Tweet)
