All News

Lupusfoto.jpg

TLR Antagonist in Lupus

d Medpage Today

An investigational Toll-like receptor (TLR) antagonist was effective in reducing biomarkers and clinical symptoms of systemic lupus erythematosus (SLE) in a pilot trial, evidence that the innate immune system may hold the key to lupus pathophysiology.

Read Article
RNL24

ICYMI: What are the Early Stages of Lupus?

d Eric Dein, MD

Incomplete lupus? Undifferentiated connective tissue disease? Pre-clinical autoimmune disease? During the lupus pod at RheumNow Live 2024, Dr. David Karp discussed the spectrum of autoimmune disease and the confusing terminology that is used with the complex world of early autoimmune disease. He cautioned against the traditional use of phrases such as incomplete lupus or undifferentiated connective tissue disease, which are heterogeneous and poorly defined.

Read Article
Predicting Infection in Lupus Nephritis Machine learning (ML) models were applied to 3 cohorts of lupus nephritis (LN) patients and established algorithms to predict co-infection in LN. https://t.co/BnV7jVfqj1 https://t.co/LYQd6w1DvD

Links:

Dr. John Cush RheumNow ( View Tweet)
Predicting CKD Outcomes in Lupus Nephritis An observational cohort study suggests that proteinuria levels in lupus nephritis (LN) patients did not predict their histologic class. https://t.co/UHNqj6WTXn https://t.co/IOc0Gv21FM

Links:

Dr. John Cush RheumNow ( View Tweet)
Venous thromboembolic event Risk study in 1854 SLE pts vs controls (12,107) from 1985–2015 in W Australia. VTE affected 12.8% SLE pts; 6 fold higher than controls (RR 6.6). Risk factors: aPL(aHR 4.24), serositis (2.7), nephritis (1.75), low Plts (1.65) https://t.co/efUUQzTNzK https://t.co/XXXXTbQOCn

Links:

Dr. John Cush RheumNow ( View Tweet)
RheumNow Podcast square

Rheum Chapter Notes (4.26.2024)

d Jack Cush, MD

Dr. Jack Cush reviews this past week’s news and journal articles from RheumNow.com.

Read Article
Predicting CKD Outcomes in Lupus Nephritis An observational cohort study suggests that proteinuria levels in lupus nephritis (LN) patients did not predict their histologic class. https://t.co/SCsuYuXgw4 https://t.co/bHB9ggf20H

Links:

Dr. John Cush RheumNow ( View Tweet)
1/3 of lupus nephritis patient classified as ""complete responders"" continued to accrue progressive renal damage despite resolution of proteinuria over 1 year. Dr. @andreafava reviews GFR trajectories after renal bx at #RNL2024 @RheumNow https://t.co/mqwhfIFQsL

Links:

Dr. John Cush RheumNow ( View Tweet)

#RNL2024 @DrDavidKarp Incomplete lupus is heterogeneous term ""Stage 2"" pre-classification stage as ILE/UCTD Stage 1: non-specific antibodies, dysregulation 2: incomplete features 3: classified, multi-system disease 4: irreversible tissue damage https://t.co/lmorwojG49

Links:

Dr. John Cush RheumNow ( View Tweet)

Urine proteomics in lupus nephritis IL-16 and CD163 are urinary biomarkers most correlated w/ histologic activity Myeloid & degranulation sign ass w histo activity -> PR3+cells abundant in LN @andreafava #RNL2024 @RheumNow https://t.co/YpoMiupOlQ

Links:

Dr. John Cush RheumNow ( View Tweet)

Venous thromboembolic event Risk study in 1854 SLE pts vs controls (12,107) from 1985–2015 in W Australia. VTE affected 12.8% SLE pts; 6 fold higher than controls (RR 6.6). Risk factors: aPL(aHR 4.24), serositis (2.7), nephritis (1.75), low Plts (1.65) https://t.co/KNInhNkjmQ https://t.co/jT3cTemxMD

Links:

Dr. John Cush RheumNow ( View Tweet)
Our final TNR for the month of April will take place on 4/30 at 6:30pm ET. Mastering SLE Rethinking Pre-Clinical Disease in Lupus - David Karp, MD Biology and Rx of Lupus Flares - Michelle Kahlenberg, MD Current/Future Biomarkers in SLE - Andrea Fava, MD https://t.co/IoRDAaAJbo https://t.co/C7HpKvehXX

Links:

Dr. John Cush RheumNow ( View Tweet)
bone.infection.gram_.rod_.jpg

Predicting Infection in Lupus Nephritis

d Jack Cush, MD

Machine learning (ML) models were applied to 3 cohorts of lupus nephritis (LN) patients and established algorithms to predict co-infection in LN. 

Read Article
DPGN, lupus, nephritis, GN, glomerulonephritis, biopsy, kidney

Predicting CKD Outcomes in Lupus Nephritis

d Jack Cush, MD

An observational cohort study suggests that proteinuria levels in lupus nephritis (LN) patients did not predict their histologic class.

A multicentre observational study of patients with biopsy-proven LN; either proliferative (PLN) or membranous (MLN) lupus nephritis were compared regarding clinical and laboratory presentation and long-term outcomes. The primary outcome was progression to chronic kidney disease (CKD).

Read Article
Single center retrospective 173 pts w/ CTD-ILD - 34% Sjogren’s, 30 RA, 25 systemic sclerosis, 6 UCTD, 3% idiopathic inflam myositis, 1,2% MCTD, 0.6% SLE. NSIP most common (60%) inSS & SSc; UIP more common in RA. 6 died, mostly infection https://t.co/IL2tnVDtoQ https://t.co/Ada49Qv5XL

Links:

Dr. John Cush RheumNow ( View Tweet)
Lupus Accelerating Breakthroughs Consortium Partners with FDA https://t.co/GW7Zy72oIZ https://t.co/AGYY8WDKcK

Links:

Dr. John Cush RheumNow ( View Tweet)
FDAmeeting.jpg

Lupus Accelerating Breakthroughs Consortium Partners with FDA

d EurekAlert!

The Lupus Research Alliance (LRA), founder and administrator of the Lupus Accelerating Breakthroughs Consortium (Lupus ABC), announced today at the Consortium’s first anniversary meeting an expanded partnership with the U.S.

Read Article
JAMA: SLE Review Drs.Siegel & Sammaritano (from HSS in NYC) published an impressive overview of SLE) in JAMA. This timely, well-written review covers the many complexities of this multi-organ disorder that affects nearly 3.4 million people worldwide. https://t.co/byr1hRA6rV https://t.co/wZeIdfTlH0

Links:

Dr. John Cush RheumNow ( View Tweet)
SLE in JAMA (authored by Drs Siegel & Sammaritano at HSS), impressive, full-read review, Covers: - Presentations: skin, Jts, brain, heme, etc - Treatments - Prognosis - Complications: CV, infx, CA - FAQs https://t.co/7WHYK3DgIf https://t.co/pC2MSCpn52

Links:

Dr. John Cush RheumNow ( View Tweet)
RheumNow Podcast square

Burnout or Retire (4.12.2024)

d Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from this past week on RheumNow.com. Is it time to worry about burnout and those who are leaving healthcare?

Read Article

Do you get our email newsletter?

Looking for the latest rheumatology news & trends? Sign up for the RheumNow weekday newsletter:

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Rheumnow.com is a news source dedicated to the field of Rheumatology. It is written by experts in the field, and written for rheumatologists and individuals working in related fields. Rheumnow.com provides daily updates on the site and in your inbox when you are signed up for our newsletter.

Copyright 2024 All Rights Reserved.

×