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The Journal of Autoimmunity reports that anti-HMRCR antibody positive, necrotizing myositis patients frequently have cutaneous lesions, moreso than previously reported.
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The ARTIS Study Group has published their analysis of (non-skin) cancer risk in rheumatoid arthritis, claiming the overall safety of biologic DMARDs and targeted synthetic DMARDs (tsDMARDs).
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Lancet Rheumatology has published a cohort analysis showing that a small but significant subset of children presenting with arthralgia or arthritis may have a pediatric malignancy.
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Dr. Jack Cush reviews and discusses the news and journal reports from the past week on RheumNow.com.
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Pfizer announced results Wednesday from its FDA-mandated postmarketing safety study of tofacitinib (Xeljanz), and they don't bode well for the drug and possibly others in its class.
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Dr. Jack Cush reviews this week’s news and journal reports featured on RheumNow.com.
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Patients with Sjogren’s syndrome are nearly 19 times more likely to develop lymphoma, so identifying factors that impact this risk development is a major goal in caring for this disorder.
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Check out this compilation of our EULAR 2021 Day 2 broadcasts below.
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Immune checkpoint inhibitors (ICI) are well known to cause immune-related adverse events (irAEs). A study from the Dutch Melanoma Treatment Registry shows that the use of checkpoint inhibitors for advanced melanoma in AID (autoimmune disease) patients did not increase the risk of irAEs, except for those with preexisting IBD.
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Dr. Jack Cush reviews and discusses more than a dozen news and journal articles from the past week on RheumNow.com.
Dr. John Cush
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The ARTIS Study Group has published their analysis of (non-skin) cancer risk in rheumatoid arthritis, claiming the overall safety of biologic DMARDs and targeted synthetic DMARDs (tsDMARDs).
https://t.co/RNWrLR53Wx https://t.co/mMmKKrX9vx
Dr. John Cush
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Analysis of Ph 3 data Tofacitinib in Ulcerative Colitis shows no increase in Cancer; rates equal to that seen w/ Tofa in RA, PsA & other biologics in UC. In 1124 pts (2576 PtYrs) there were 20 cancers, excluding NMSC (IR, 0.75; 0.46–1.16) https://t.co/xiTIKYAtyY
Dr. John Cush
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Can Focus Score Predict Risk of Lymphoma in Sjogren's Patients?
https://t.co/kBptqUx2XG https://t.co/8y1736Kj8T
Dr. John Cush
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Can the Focus Score predict Lymphoma in Sjogren’s syndrome? by Dr. Eric Dein ( @ejdein1 )
https://t.co/B5HN6ju3ru https://t.co/3MuXH66YqJ
Dr. John Cush
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Video: RA and Cancer: Myth or Reality? Dr. Jonathan Kay ( @RheumKay )
Dr. Kay reviewed highlights from the "Oncorheumatology: the crossroads of cancer and musculoskeletal diseases" scientific session including abstract OP0187, presented at #EULAR2021.
https://t.co/KaLEZ67L5S https://t.co/6MHXyffO2W
Eric Dein
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#EULAR2021 POS0230: TNFi changes intestinal microbiota in IBD-SpA
⬇️ Proteobacteria
⬆️Lachnospiraceae, Coprococcus
Does inflammatory changes by TNFi restore intestinal eubiosis and does this affect SpA outcomes?
@Rheumnow
Robert B Chao, MD
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⭐️All cancer excluding NMSC - 0.9HR TNFi vs cDMARD
⭐️Squamous cell CA - 1.2HR of TNFi vs cDMARD
⭐️No overall increase in all CA: RTX, TOCI
⭐️Abatacept 1.21HR for all cancer, mainly NMSC
⭐️needs more data on JAKs, IL-17, IL-23
Abs#6916
#EULAR2021 @RheumNow
ARD & RMD Open
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OP0186 #EULAR2021 by Dr. Mariele Gatto.
Anti-cancer effect of immunotherapy with ICI is believed to be mediated by CD8 positive Tc cells.
It is not known if other cells get activated. This study looks at B cells.
Transitional B cells ⬆️ in ICI induced arthritis (CP-IA).
/TK https://t.co/szFF81SKVL
Dr. John Cush
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Checkpoint Inhibitor Safety in Melanoma Patients with AID
A study from the DMT shows that the use of checkpoint inhibitors for advanced melanoma in AID patients didn't increase the risk of irAEs, except for those with preexisting IBD.
https://t.co/VFzBOlc0wc https://t.co/0zfr8YFmZr
Dr. John Cush
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Great reminder of from Dr. Kathryn Dao, @KDAO2011 from #RNL2021
Caution! Verrucous LE can simulate skin cancer! Both can be found in photosensitivity areas!
#RheumNow
