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Psoriatic Pregnancies Pose Risks to the Mother, Not Child
A metanalysis of pregnancy outcomes in women with psoriasis and psoriatic arthritis finds an excess risk of adverse maternal events, but not adverse neonatal events.
This systematic review included 16 studies meeting inclusion criteria.
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RheumNow Podcast – Infection in ANCA-Associated Vasculitis (3.26.2021)
Dr. Jack Cush reviews the news, FDA Denials and journal articles from the past week on RheumNow.com.
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RheumNow Podcast – Tofacitinib Safety Concerns (2.5.2021)
Dr. Jack Cush reviews and discusses the news and journal reports from the past week on RheumNow.com.
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This three minute video is a great watch-- is Cetrolizumab safe in pregnancy?
Dr. Kathryn Dao ( @kdao2011) shares learnings from #EULAR2021.
https://t.co/Tx4TLr4J1Y https://t.co/rOVBqX07hc
Links:
Dr. John Cush RheumNow ( View Tweet)
Video: Impact of RA on Male Fertility: New Data: Dr. Aurelie Najm
Dr. Aurelie Najm reviews abstracts OP0211 and OP0212 presented at the virtual #EULAR2021 meeting.
https://t.co/AHwhyLiwD0 https://t.co/sm7cSBPIBV
Links:
Dr. John Cush RheumNow ( View Tweet)
Current approach to lupus and pregnancy by Dr. Robert Chao ( @doctorRBC) #EULAR2021
https://t.co/eFd6j9YZo5 https://t.co/tW9tJIRpjm
Links:
Dr. John Cush RheumNow ( View Tweet)
Excellent talk on SLE, APS abs pregancy
⭐️pregnancy counseling is important
⭐️aspirin 81mg in all pregnant SLE pts
⭐️do not discontinue HCQ
⭐️stable LN - can switch MMF to AZA
Abs#6888
#EULAR2021 @RheumNow
Robert B Chao, MD doctorRBC ( View Tweet)
#POS0022 prosp study of CTZ pregnancies: 1392 preg w/1425 outcomes @UCBUSA database
88.4% live births, 10.5% preg loss, 0.8% still birth
2.4% congen malform (w/2.1% major)
Preg loss⬅️Crohn's, NSAIDS, MTX
Preterm labor⬅️GCs, maternal infx
⬇️birth wt⬅️RA & GCs @rheumnow #EULAR2021 https://t.co/qnNcDIz8Ge
k dao KDAO2011 ( View Tweet)
DANBIO + Swedish register SGR linked to national birth registers (matched 1:10): RA-pregnancies: higher preterm birth (OR 1.92, 95CI 1.56-2.35) and small gestational age (OR 1.93, 95CI 1.45-2.57). Association strengthened by high disease activity.
#OP0210 @Rheumnow #EULAR2021 https://t.co/Fjm0uxCPgC
Aurelie Najm AurelieRheumo ( View Tweet)
What is the impact of RA on fertility in men:
#OP0211 and #OP0212 @Rheumnow #EULAR2021
Aurelie Najm AurelieRheumo ( View Tweet)
Dr Hellgren on pregnancy outcomes in RA 📈disease activity assoc preterm birth and small gestational age. Low disease activity = no increased risk compared controls @RheumNow #EULAR2021 Abstr#OP0210 https://t.co/L26xWhIFv6
Richard Conway RichardPAConway ( View Tweet)
Pregnancy is a minefield for RA pts:
dx activity➡️preg risk
PNL➡️preg risk, but dx activity proxy?
bring on Swedish/Danish linked data:
1739 RA preg matched 1:10
⬆️pre-term/SGA risk with bDMARDs/PNL
adj for dx activity: less bad, but still concern?
OP0210 #EULAR2021 @RheumNow https://t.co/AlwFtmGcZH
David Liew drdavidliew ( View Tweet)
Complements that are low in #SLE pregnancy have POORER fetal outcomes. What happens to C3 & C4 in pregnancy? They should ⬆️ by 28% C3, 11% C4 in 1st Trimester @RheumNow #EULAR2021 POS0103. So order C3&C4 early in pregnancy in SLE & follow! https://t.co/FpHHj74e43
Janet Pope Janetbirdope ( View Tweet)
C3 and C4⬆️in SLE pregnancy like they would in pregnancies w/o SLE!
French GR2 prospective study of 290 SLE pregnancies quantifies mean C3 value⬆️by 28%, C4⬆️by 11% from 1st ➡️3rd trimester. Remember this when assessing disease activity. #EULAR2021 Abstr #0103 @rheumnow https://t.co/TXjO4mjNJE
k dao KDAO2011 ( View Tweet)
#LupusAwarenessMonth
Dr. Kathryn Dao - Pregnancy Outcomes in Lupus, SpA
From ACR 2020
https://t.co/TvlqwZqgOv https://t.co/UBeVghYh0g
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Dr. John Cush RheumNow ( View Tweet)
Metanalysis of 9 studies, and 1132 lupus pregnancies shows that hydroxychloroquine treatment significantly reduced the risk of preeclampsia (OR 0.35), pregnancy hypertension (OR0.41)and prematurity (OR 0.55), but no effect on rates of HELLP, DM, Ab https://t.co/P9MXjDpuiO
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Dr. John Cush RheumNow ( View Tweet)
News Feature: Psoriatic Pregnancies Pose Risks to the Mother, Not Child
https://t.co/kZE2yLEvm7
Links:
Dr. John Cush RheumNow ( View Tweet)
Email Survey study of HSS rheumatic pts 7,094 responded 1,547 were women (18-50yrs) & 61 (4%) were pregnant during COVID. COVID prevalence was similar in PREG vs nonPREG (8% vs.9% ), PREG COVID pts had shorter Sxs, more loss taste/smell. https://t.co/4HDuXbZVrs
Links:
Dr. John Cush RheumNow ( View Tweet)
Dr Uma Mahadevan presents results of the 14 yr registry study of pregnancy in IBD (Crohn's &UC) 1431 pts on with no Rx, thiopurines, biologics or thiop+biologics, showed no rush of fetal malformation, but did have incr in spont abortions @RWCSmtg @UmaMahadevanIBD https://t.co/SVQ2q1mJNW
Dr. John Cush RheumNow ( View Tweet)
309 RA pts from the Preconception Counseling in Active RA (PreCARA) cohort were treated according to a modified T2T approach, 188 children were born. 47% of pts were on a TNFi during Preg; 75% were in LDAremission before PREG but 90% by 3rd trimester https://t.co/eLffxrH0UV
Links:
Dr. John Cush RheumNow ( View Tweet)
