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RheumNow Podcast – Modern Treatment of RA Pregnancy (6.25.2021)
Dr. Jack Cush reviews this week’s news and journal reports featured on RheumNow.com.
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Better Outcomes with Modern T2T in Pregnancy
With the expansion of knowledge regarding the safety of newer agents in pregnancy comes the PreCARA study showing that when pregnancy is planned and patients with rheumatoid arthritis (RA) are treated with a modified treat-to-target (T2T) approach, superior outcomes can be anticipated.
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Current approach to lupus and pregnancy
All of us are extremely cautious with lupus patients when it comes to pregnancy. Presentation 6888 (Common issues in pregnancy management in lupus and anti-phospholipid syndrome by Dr. Rebecca Fischer-Betz) was an excellent overview of our current approach to lupus and pregnancy.
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What's the impact of RA on male fertility?
Dr. Aurelie Njam shares new data provided at #EULAR2021.
https://t.co/AHwhyLiwD0 https://t.co/pFKoADZ2sh
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Dr. John Cush RheumNow ( View Tweet)
Rheumatoid arthritis in either partner can affect fertility and pregnancy outcomes. Dr. Kay discusses abstract OP0210, abstract OP0212 and abstract OP0211 presented at the virtual EULAR meeting.
https://t.co/Y9uVBGmxcP https://t.co/YVz08q67gc
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Dr. John Cush RheumNow ( View Tweet)
What about Babies of Patients with Inflammatory Arthritis?
Dr. Janet Pope ( @Janetbirdope) shares the results from study OP0211. #EULAR2021
https://t.co/odLknwNlMv https://t.co/AmsaSg9Gwe
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Dr. John Cush RheumNow ( View Tweet)
This three minute video is a great watch-- is Cetrolizumab safe in pregnancy?
Dr. Kathryn Dao ( @kdao2011) shares learnings from #EULAR2021.
https://t.co/Tx4TLr4J1Y https://t.co/rOVBqX07hc
Links:
Dr. John Cush RheumNow ( View Tweet)
Video: Impact of RA on Male Fertility: New Data: Dr. Aurelie Najm
Dr. Aurelie Najm reviews abstracts OP0211 and OP0212 presented at the virtual #EULAR2021 meeting.
https://t.co/AHwhyLiwD0 https://t.co/sm7cSBPIBV
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Dr. John Cush RheumNow ( View Tweet)
Current approach to lupus and pregnancy by Dr. Robert Chao ( @doctorRBC) #EULAR2021
https://t.co/eFd6j9YZo5 https://t.co/tW9tJIRpjm
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Dr. John Cush RheumNow ( View Tweet)
Excellent talk on SLE, APS abs pregancy
⭐️pregnancy counseling is important
⭐️aspirin 81mg in all pregnant SLE pts
⭐️do not discontinue HCQ
⭐️stable LN - can switch MMF to AZA
Abs#6888
#EULAR2021 @RheumNow
Robert B Chao, MD doctorRBC ( View Tweet)
#POS0022 prosp study of CTZ pregnancies: 1392 preg w/1425 outcomes @UCBUSA database
88.4% live births, 10.5% preg loss, 0.8% still birth
2.4% congen malform (w/2.1% major)
Preg loss⬅️Crohn's, NSAIDS, MTX
Preterm labor⬅️GCs, maternal infx
⬇️birth wt⬅️RA & GCs @rheumnow #EULAR2021 https://t.co/qnNcDIz8Ge
k dao KDAO2011 ( View Tweet)
DANBIO + Swedish register SGR linked to national birth registers (matched 1:10): RA-pregnancies: higher preterm birth (OR 1.92, 95CI 1.56-2.35) and small gestational age (OR 1.93, 95CI 1.45-2.57). Association strengthened by high disease activity.
#OP0210 @Rheumnow #EULAR2021 https://t.co/Fjm0uxCPgC
Aurelie Najm AurelieRheumo ( View Tweet)
What is the impact of RA on fertility in men:
#OP0211 and #OP0212 @Rheumnow #EULAR2021
Aurelie Najm AurelieRheumo ( View Tweet)
Dr Hellgren on pregnancy outcomes in RA 📈disease activity assoc preterm birth and small gestational age. Low disease activity = no increased risk compared controls @RheumNow #EULAR2021 Abstr#OP0210 https://t.co/L26xWhIFv6
Richard Conway RichardPAConway ( View Tweet)
Pregnancy is a minefield for RA pts:
dx activity➡️preg risk
PNL➡️preg risk, but dx activity proxy?
bring on Swedish/Danish linked data:
1739 RA preg matched 1:10
⬆️pre-term/SGA risk with bDMARDs/PNL
adj for dx activity: less bad, but still concern?
OP0210 #EULAR2021 @RheumNow https://t.co/AlwFtmGcZH
David Liew drdavidliew ( View Tweet)
Complements that are low in #SLE pregnancy have POORER fetal outcomes. What happens to C3 & C4 in pregnancy? They should ⬆️ by 28% C3, 11% C4 in 1st Trimester @RheumNow #EULAR2021 POS0103. So order C3&C4 early in pregnancy in SLE & follow! https://t.co/FpHHj74e43
Janet Pope Janetbirdope ( View Tweet)
C3 and C4⬆️in SLE pregnancy like they would in pregnancies w/o SLE!
French GR2 prospective study of 290 SLE pregnancies quantifies mean C3 value⬆️by 28%, C4⬆️by 11% from 1st ➡️3rd trimester. Remember this when assessing disease activity. #EULAR2021 Abstr #0103 @rheumnow https://t.co/TXjO4mjNJE
k dao KDAO2011 ( View Tweet)
#LupusAwarenessMonth
Dr. Kathryn Dao - Pregnancy Outcomes in Lupus, SpA
From ACR 2020
https://t.co/TvlqwZqgOv https://t.co/UBeVghYh0g
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Dr. John Cush RheumNow ( View Tweet)
Metanalysis of 9 studies, and 1132 lupus pregnancies shows that hydroxychloroquine treatment significantly reduced the risk of preeclampsia (OR 0.35), pregnancy hypertension (OR0.41)and prematurity (OR 0.55), but no effect on rates of HELLP, DM, Ab https://t.co/P9MXjDpuiO
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Dr. John Cush RheumNow ( View Tweet)
News Feature: Psoriatic Pregnancies Pose Risks to the Mother, Not Child
https://t.co/kZE2yLEvm7
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Dr. John Cush RheumNow ( View Tweet)
