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Hydroxychloroquine (HCQ) is one of the safest meds used in rheumatology, but there is new claims data suggesting a small increase in the risk of malformations associated with first-trimester HCQ use.
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Dr. Jack Cush reviews and discusses the news and journal reports from the past week on RheumNow.com.
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2020 was historic, memorable and game-changing. Under the cloud of COVID-19, there were many significant and memorable advances and setbacks for the rheumatology world. In our accounting of most read articles for 2020, (not surprisingly) 17/20 were COVID-related.
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Dr. Jack Cush reviews this week’s news and journal reports featured on RheumNow.com.
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With the expansion of knowledge regarding the safety of newer agents in pregnancy comes the PreCARA study showing that when pregnancy is planned and patients with rheumatoid arthritis (RA) are treated with a modified treat-to-target (T2T) approach, superior outcomes can be anticipated.
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All of us are extremely cautious with lupus patients when it comes to pregnancy. Presentation 6888 (Common issues in pregnancy management in lupus and anti-phospholipid syndrome by Dr. Rebecca Fischer-Betz) was an excellent overview of our current approach to lupus and pregnancy.
Dr. John Cush
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Top Tweet Last Week:
Potential Birth Defects with Hydroxychloroquine
HCQ is one of the safest meds used in rheumatology, but there is new claims data suggesting a small increase in the risk of malformations associated with first-trimester HCQ use.
https://t.co/IHNKjHVXaU https://t.co/Oay2ayVr9m
Dr. John Cush
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Survey of women re: sex & reproduction (SRH) says women prefer 1) Rheums to initiate SRH discussions, 2) clear info on pregnancy & infertility risks w/ Dz & DMARDs, 3) holistic Rx approach, 4) not to be intermediaries betw Rheum & OB https://t.co/Orlh6gLO6P https://t.co/rS4r39Easx
Dr. John Cush
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Metanalysis of 9 studies, and 1132 lupus pregnancies shows that hydroxychloroquine treatment significantly reduced the risk of preeclampsia (OR 0.35), pregnancy hypertension (OR0.41)and prematurity (OR 0.55), but no effect on rates of HELLP, DM, Ab
https://t.co/P9MXjDpuiO https://t.co/DxVWiUAPpe
Dr. John Cush
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With the expansion of knowledge regarding the safety of newer agents in pregnancy comes the PreCARA study showing that when pregnancy is planned and patients with RA are treated with a modified T2T
approach, superior outcomes can be anticipated.
Read on:
https://t.co/sV5hJRzPJW https://t.co/ADppVd3CmZ
Dr. John Cush
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What's the impact of RA on male fertility?
Dr. Aurelie Njam shares new data provided at #EULAR2021.
https://t.co/AHwhyLiwD0 https://t.co/pFKoADZ2sh
Dr. John Cush
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Rheumatoid arthritis in either partner can affect fertility and pregnancy outcomes. Dr. Kay discusses abstract OP0210, abstract OP0212 and abstract OP0211 presented at the virtual EULAR meeting.
https://t.co/Y9uVBGmxcP https://t.co/YVz08q67gc
Dr. John Cush
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What about Babies of Patients with Inflammatory Arthritis?
Dr. Janet Pope ( @Janetbirdope) shares the results from study OP0211. #EULAR2021
https://t.co/odLknwNlMv https://t.co/AmsaSg9Gwe
Dr. John Cush
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This three minute video is a great watch-- is Cetrolizumab safe in pregnancy?
Dr. Kathryn Dao ( @kdao2011) shares learnings from #EULAR2021.
https://t.co/Tx4TLr4J1Y https://t.co/rOVBqX07hc
Dr. John Cush
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Video: Impact of RA on Male Fertility: New Data: Dr. Aurelie Najm
Dr. Aurelie Najm reviews abstracts OP0211 and OP0212 presented at the virtual #EULAR2021 meeting.
https://t.co/AHwhyLiwD0 https://t.co/sm7cSBPIBV
Dr. John Cush
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Current approach to lupus and pregnancy by Dr. Robert Chao ( @doctorRBC) #EULAR2021
https://t.co/eFd6j9YZo5 https://t.co/tW9tJIRpjm
Robert B Chao, MD
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Excellent talk on SLE, APS abs pregancy
⭐️pregnancy counseling is important
⭐️aspirin 81mg in all pregnant SLE pts
⭐️do not discontinue HCQ
⭐️stable LN - can switch MMF to AZA
Abs#6888
#EULAR2021 @RheumNow
k dao
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#POS0022 prosp study of CTZ pregnancies: 1392 preg w/1425 outcomes @UCBUSA database
88.4% live births, 10.5% preg loss, 0.8% still birth
2.4% congen malform (w/2.1% major)
Preg loss⬅️Crohn's, NSAIDS, MTX
Preterm labor⬅️GCs, maternal infx
⬇️birth wt⬅️RA & GCs @rheumnow #EULAR2021 https://t.co/qnNcDIz8Ge
Aurelie Najm
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DANBIO + Swedish register SGR linked to national birth registers (matched 1:10): RA-pregnancies: higher preterm birth (OR 1.92, 95CI 1.56-2.35) and small gestational age (OR 1.93, 95CI 1.45-2.57). Association strengthened by high disease activity.
#OP0210 @Rheumnow #EULAR2021 https://t.co/Fjm0uxCPgC
Aurelie Najm
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What is the impact of RA on fertility in men:
#OP0211 and #OP0212 @Rheumnow #EULAR2021
