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High False Negative Rate with PFTs in Scleroderma
Researchers in Zurich studed 102 systemic sclerosis with serial PFTs and high-resolution computed tomography of the chest (HRCT). They found significant interstitial lung disease (ILD) by HRCT in 63 percent.
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The FASSCINATE study presented at EULAR 2015 was instrumental in tocilizumab (TCZ) getting a nod from the FDA to develop TCZ for scleroderma.
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2015 Guidelines for Idiopathic Pulmonary Fibrosis
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrosing form of interstitial pneumonia, with poor survival rates of nearly 50% at 3 years.
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Troponin and BNP in the Diagnosis of Pulmonary Hypertension
Common cardiac biomarkers could be used to identify patients with systemic sclerosis (SSc) at risk for developing pulmonary hypertension, French researchers reported.
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Fresolimumab (anti-TGF beta) Improves Systemic Sclerosis
Transforming growth factor (TGF-β) is known to have potent profibrotic activity and has been implicated in the pathogenesis of systemic sclerosis a futile condition with no effective disease modifying treatments.
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Management of Digital Ulcers in Scleroderma
Currently there are no FDA-approved medications for the treatment of digital ulcerations in the United States. Digital ulcers are a common, unfortunate and difficult to manage consequence of the vascular obliteration and fibrosis that accompanies systemic sclerosis.
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The EULAR 2015 Report- Friday
These abstracts and presentations were presented 12 June at the EULAR 2015 annual meeting.
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Difficulties Diagnosing Interstitial Lung Disease in Scleroderma
The diagnosis of chronic lung disease in patients with systemic sclerosis may be difficult because of atypical symptoms, variable evolution and limitations of current classification criteria for a definite diagnosis. Nevertheless, diagnosis is necessary as patients with SSc-ILD have a p
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Sildenafil May Help Heal Scleroderma Ulcers
A prospective study of sildenafil was conducted in 25 centers that included 83 patients and 192 digital ulcers at entry. The odds of healing ulcers was less, but not significant, for sildenafil.
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