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Normalizing Serologies Enhances Remission in SLE

d Jack Cush, MD

Analysis of five phase III belimumab (BEL) trials reveals that normalizing serologies affords protection against severe and renal SLE flares, supporting the concept of treat-to-target to minimize risk in SLE.

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Knee,injection

Intraarticular Steroids in OA Lowers Need for Pain Meds

d MedPage Today

Is it possible that intra-articular corticosteroid injections for osteoarthritis might affect the use of opioids?

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AI,genes

SOCS1 Insufficiency - a Rare Inborn Error of Immunity

d Jack Cush, MD

Lancet Rheumatology has published a population study of the rare suppressor of cytokine signalling 1 (SOCS1) insufficiency - an inborn error of immunity affecting the negative regulation of cytokine and growth factor signalling.

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Early Hydroxychloroquine Slows Cutaneous Lupus Progression

d Jack Cush, MD

A prospective study of patients with limited cutaneous lupus erythematosus shows that early introduction of hydroxychloroquine may prevent progression to systemic lupus erythematosus.

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Full read review of Hydryoxychloroquine -its pharmacology, MOA (eg, blocking TLR 7 & 9), Dz specific efficacy and adverse effects https://t.co/WVErW1RrCj https://t.co/eQVFIZNSRx

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Bubble Trouble - When Bullous Lupus Bursts onto the SLE Scene Presentation by Dr. Alana Haussmann at the Rheumatology Winter Clinical Symposia - Feb 2025 https://t.co/LRsT1TLEm4 https://t.co/bSi50pDn2O

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Opioid Deaths are Down (2.28.2025) Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow. Opioid deaths are down, IL-33 levels are up and Weight loss is in the news again this week! https://t.co/Lb6F64AlNJ https://t.co/7AjSXOn142

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Loss of Good Sleep Linked to All-Cause Mortality A US study shows that nearly two-thirds of the population had suboptimal 5-year sleep duration trajectories with a resultant 29% increase in risk of all-cause mortality. https://t.co/GXkIDC2uSQ https://t.co/wYzpnK9BMQ

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Recurrent Pericarditis in Lupus A study from the Lupus Hopkins Cohort shows that systemic lupus erythematosus (SLE) patients with pericarditis are at risk for recurrence, and likely to be younger patients, with uncontrolled disease, and linkage to higher doses of oral… https://t.co/hML8NfhBy3 https://t.co/cKX5KaSg3a
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Risk of Cancer on JAKi in RA (12 463 vs 38 345 controls). No incr risk of CA w/ exposure to JAKi (adj OR 1.04), TNFi (0.98), other bDMARDs (0.98). But JAKi was assoc w/ signif more lung CA (1.40; esp in males 2.12) & less breast CA (0.62) in women https://t.co/fr3VjPhJve https://t.co/zNehdWBbeI

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Selective mutation of Traf1/cIAP2 (V196) interaction attenuates inflammatory responses that may contribute to rheumatoid arthritis activity. THis may lead to a new class of therapies for RA https://t.co/kYqAqGsSEA https://t.co/JWUN6iTvxa

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I ALWAYS recommend paraffin wax baths for stiffness, RA, OA, PSS, etc. Here are some instructions for home use https://t.co/CTI4K2kHf9 https://t.co/i0kO99vdYc

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AbbVie Receives Positive CHMP Opinion for Upadacitinib (RINVOQ®) for the Treatment of Adults with Giant Cell Arteritis https://t.co/WP8JGpHc6p https://t.co/x9m870mCJ4

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UK MRCP exam makeup: Cardio 15% Pharm 15% Resp 10% GI 10% Neuro 10% ID 8% Endo 8% RHEUM 6% Heme 5% Renal 5% Derm 4% Eye 2% Psych 2% https://t.co/WG7X3B8a0Y https://t.co/9VF5LkLJjs

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Cochrane review of TNF inhib. in #JIA shows TNFi efficacy, but uncertainty about LT safety, pain, function, & Dz control - esp compared to MTX. 9 studies, 678 JIApts, age 8-15 yrs (80% F), Dz duration 0.8-6.7 yrs. Withdrawls 1% v 3%; Serious AE 6% v 7% (PBO vs TNFi).… https://t.co/i35m5uzG1m https://t.co/VzJN9PmmMh
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"Never take the advice of someone who has not had your kind of trouble" - Sidney J. Harris https://t.co/xdB6u6OiPq
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Ankle Fusion or Total Replacement? In a large study of British patients needing surgical treatment for advanced arthritis in the ankle, fusion appeared to be a better option than total ankle replacement. https://t.co/ZFbd2VinpP https://t.co/QCqMkxNLoQ

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Schnitzler Syndrome: A Rare Autoinflammatory Disorder A credible, quick overview Chronic Urticaria Monoclonal Gammopathy ( Recurrent Fever Bone & Joint Pain Elevated CRP &ESR https://t.co/sQ22t8Z46m https://t.co/nJOVCghoFa

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Diagnoses via Immune ‘Fingerprints’ Science and researchers at Stanford Medicine have reported the use of Mal-ID (machine learning for immunological diagnosis) to analyze B and T cell receptors (BCRs and TCRs) sequences from human blood, showing the ability to predict health… https://t.co/nqyf4iaD10 https://t.co/wt5V6uxLYf
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JAMA Case: A Woman With Painful Digital Ulcers - What would you order next? - chest CT w/ myositis-specific autoAb panel - dsDNA - SCL-70 & Centromere Abs - muscle biopsy https://t.co/t0WCIMtZg2 https://t.co/M1jBhnclLl

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