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EULAR 2023 Notes from Milan (6.09.2023)
Dr. Jack Cush reviews highlight abstracts and sessions - covering lupus, RA, gout, Still's disease, safety data, AI in medicine and more - from last week's EULAR 2023 Congress held in Milan, Italy.
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Combining a Tyk2 inhibitor with a JAKi in RA?
At EULAR 2023, there was a late breaking abstract that compared difficult to treat patients with RA who had received treatment (including TNFi and JAKi in some patients) previously and still had active disease.
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Zoster protection for JAK inhibitor patients appears achievable
One of the primary questions about JAK inhibitor safety, ever since its first approval, has been the risk of herpes zoster.
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EULAR 2023 – Day 3 Report
Day 3 was a sunny warm day in Milan at the 2023 EULAR Congress meeting. Here are a few of my favorite abstracts from today.
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Metanalysis of 62 RCTs, 16 LTEs of JAKi, placebo, TNFi, & MTX Rx pts shows that malignancy incidence rate =1.15-1.26/100 Pt-Yrs. Neoplasia risk w/ JAKi = PBO or MTX risk (IRR 0.71 & 0.77); but JAKi CA risk if compared to TNFi (IRR 1.50;1.16 to 1.94) https://t.co/uOgPFlJ2z1 https://t.co/Ynh6SMQdke
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Dr. John Cush RheumNow ( View Tweet)
WATCH: JAKpot or JAKnot
Dr. Jack Cush, executive editor of RheumNow, reporting on abstract OP0219 from EULAR 2023 in Milan, Italy.
https://t.co/RSJX4hcMRU https://t.co/XYuOrSCxjf
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Dr. John Cush RheumNow ( View Tweet)
JAKi in Rheumatoid Arthritis: Cancer and Cardiovascular Risks
Dr. Antoni Chan discusses abstracts OP0132, POS0831, and OP0133 presented at EULAR 2023 in Milan, Italy.
https://t.co/ApLaPf7uKP https://t.co/nbZgwIlHyb
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Dr. John Cush RheumNow ( View Tweet)
SLE Trial: Dual BTK JAK Blockade compared Upadacitinib Monotherapy
Dr. Yuz Yusof discusses abstract OP0139 presented at EULAR 2023 in Milan, Italy.
https://t.co/os1tyiDnuT https://t.co/G0owdGek7f
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Dr. John Cush RheumNow ( View Tweet)
CV and Cancer Risk with JAK inhibitors
Dr. Jonathan Kay discusses abstract OP0132 presented at EULAR 2023 in Milan, Italy.
https://t.co/SZLohnNEa1 https://t.co/ZEv0Q2NSBf
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Dr. John Cush RheumNow ( View Tweet)
An update on JAK inhibitors and cardiovascular risks
Dr. Antoni Chan ( @synovialjoints ) shares #EULAR23 developments on JAK/TYK2 inhibitors.
https://t.co/VovWE2OuXW https://t.co/QXKZLh5RuK
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Dr. John Cush RheumNow ( View Tweet)
JaL1/TYK2 inhibitor vs Tofacitinib in #RA at #EULAR2023 phase 2. @RheumNow https://t.co/0F3JQ9dVMA
Bella Mehta bella_mehta ( View Tweet)
Abstracts talking about #RA and JAKs and Biologic comparisons
Huge number of pts to analyze this aftrr the initial NEJM study. Abstract summary pics below
@RheumNow https://t.co/jl5S4fLq19
Bella Mehta bella_mehta ( View Tweet)
#EULAR2023 recommendation update summary from the 2018 in #PsA whats new!
- 3 more drugs now available in PsA. – Guselkumab, Upadacitnib, Risankizumab (1 more in the pipeline)
- safety now to to considered!
- consider the full picture - extraarticular manifestations
@rheumnow https://t.co/7GBILtCX4i
Bella Mehta bella_mehta ( View Tweet)
Obviously lots of real world data at #EULAR2023 on JAKi safety (cardiovascular & cancer, see ORAL Surveillance).
Real problem:
many still have shorter follow-up periods. Cancer in particular takes time. It’s great to see data now, but:
*longer follow-up needed* +++
@RheumNow https://t.co/YH4fZgNQjY
David Liew drdavidliew ( View Tweet)
Amazing the chatter in the room for this one. The idea that a new JAKi might genuinely outperform existing JAKi in hard-to-treat RA, without safety cost, is particularly enticing.
We all want to see the paper & healthy skepticism of ph2, but watch this space #EULAR2023 @RheumNow https://t.co/jEyk8zqZN8
David Liew drdavidliew ( View Tweet)
What about a new oral drug in active #rheumatoid #arthritis vs #JAKi #Tofacitinib? TLL-018 a potent JAK1/TYK2 inhibitor was compared with #Tofa and dose ranging of 10, 20, 30 mg of TLL-018 and many Pts w past TNFi and w JAKi. High dose won #EULAR2023 @RheumNow @eular_org LB0001 https://t.co/UXhT7LV1oD
Janet Pope Janetbirdope ( View Tweet)
An update on JAK inhibitors and cardiovascular risks
Dr. Antoni Chan ( @synovialjoints ) shares #EULAR23 developments on JAK/TYK2 inhibitors.
https://t.co/yZqHEg73bn https://t.co/CzVH62LEgL
Links:
Dr. John Cush RheumNow ( View Tweet)
Tune it at 1pm EST for RheumNow's daily #EULAR23 recaps. You can find us live on Twitter, YouTube and LinkedIn. https://t.co/t531csjXo8
Dr. John Cush RheumNow ( View Tweet)
Herpes Zoster vaccination in RA patients treated with Upadacitinib and MTX showed a satisfactory response,
slight reduction in response compared to general population in both antibody and cell mediated responses Winthrop K, Abst#OP0225 #EULAR2023 @RheumNow https://t.co/wxwbOYsn5K
Dr. Antoni Chan synovialjoints ( View Tweet)
