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ICYMI: EULAR Guidelines on Intraarticular Therapy
EULAR has published evidence-based recommendations on the use of intra-articular therapies (IAT) based on the literature review and recommendations of a multidisciplinary international task force. These IAT recommendations apply to adult patients with peripheral arthropathies.
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RheumNow Podcast – As Good As I Ever Was (7.2.2021)
Dr. Jack Cush reviews the news and journal reports from this past week on RheumNow.com.
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Knee Replacement in Obese OA is Cost Effective
Debates over ideal candidates for total knee replacement (TKR) in osteoarthritis patients often excludes those who are obese, but a recent article in the Annals of Internal Medicine suggests that TKR is both effective and cost-effective in obese patients (BMI >40 kg/m2) with
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Botanical extract, Chrysanthemum zawadskii var. latilobum (GCWB) studied in 112 w/ mild-mod. knee OA. Randomized, double-blind, placebo-controlled study finds GCQB signif better than placebo in WOMAC total & function scores https://t.co/xyKlrL2CG7
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Dr. John Cush RheumNow ( View Tweet)
Carpal Tunnel Syndrome has an annual incidence of 0.4%. Population based study shows more likely in women, 50-59 years, w/ obesity, gout, rheumatoid arthritis or a prior hx of wrist injury. https://t.co/X7U5yh0R3l
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Dr. John Cush RheumNow ( View Tweet)
ICYMI: News: EULAR Guidelines on Intraarticular Therapy
EULAR has published evidence-based recommendations on the use of intra-articular therapies (IAT) based on the literature review and recommendations of a multidisciplinary international task force.
https://t.co/Z6vC0x9zY1 https://t.co/dKpjpo50YT
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Dr. John Cush RheumNow ( View Tweet)
Knee corticosteroids injx within 4 wks of total joint arthroplasty may be assoc w/ a higher risk of postop infection (studies suggest a risk w/in 3 mos of TKA). Greatest risk seen w/in 2 wks of injx (OR 2.89), worse in <65 yrs & w/ comorbidities (RA) https://t.co/nZKTkv7ym5 https://t.co/4W6CNsrqpf
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Dr. John Cush RheumNow ( View Tweet)
Hands-Down Rheumatology - Gout doesnt get to the hands until its done its damage below (MTP, ankle, knee) and usually only in those with severe tophaceous gout Can also present as dactylitis or Carpal tunnel. Women on diuretics w/ CKD can get gout in Nodal OA joints https://t.co/Ri5taWpR0p
Dr. John Cush RheumNow ( View Tweet)
Health care utilization by knee OA pts varies. In nearly 1 million Knee OA (Medicare), 33% ended up with TKR. TKR/arthroplasty assoc w/ more clinic visits; PT, specialist care & intraarticular Rx assoc. w/ less TKR. TKR range 26% to 42% by region https://t.co/d1EQTTie8X
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Dr. John Cush RheumNow ( View Tweet)
Higher rate of Parkinsonism in Osteoarthritis? Taiwan Health Insurance claims analysis of 33,360 OA pts (age 50-64 yrs) vs age matched non-OA - found incr risk of Parkinsons in OA pts (aHR=1.41), esp in knee or hip OA (aHR 1.55) group. https://t.co/SHudF5NnwH
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Dr. John Cush RheumNow ( View Tweet)
Stroke risk is increased in arthritis (RR 1.36, 95% CI: 1.27–1.46); esp for RA (RR 1.38), AS (RR 1.49), PsA (1.33) & gout (1.40); but NOT osteoarthritis (RR=1.03). Apparently Inflammation drives this risk. https://t.co/Snb6OrtZJH
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Dr. John Cush RheumNow ( View Tweet)
Don't Kill the Krill!
Dr. Kathryn Dao ( @KDAO2011) reviews abstract POS0276 regarding the efficacy of krill oil in knee OA, presented at the virtual EULAR 2021 meeting.
https://t.co/gX2hivyCs2 https://t.co/QaU7A7gM8j
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Dr. John Cush RheumNow ( View Tweet)
Time to go raspberry picking?
Rubus idaeus leaf extract 400mg and 200mg after 12 weeks
⬇️ VAS pain in knee OA compared to placebo
⭐️no effect on WOMAC, SF-36, 20m walking
Abs#POS0281
#EULAR2021 @RheumNow https://t.co/QAiag2XjRh
Robert B Chao, MD doctorRBC ( View Tweet)
A single dose of LORECIVIVINT IA (Wnt pathway modulator) in Phase 3 study in knee OA: mild improvement of WOMAC pain -8.16[-15.60, -0.71] P=0.032 and function -9.47[-17.09, -1.84] P=0.015 at 6 and 12months with no particular safety signal. #POS0278 #EULAR2021 @RheumNow https://t.co/5qQE6MPjnU
Aurelie Najm AurelieRheumo ( View Tweet)
Sounds fishy! Krill oil in #osteoarthritis is not a good catch! Fully neg RCT POS0276 @eular_org @RheumNow #EULAR2021 https://t.co/OGZbltDyxg
Janet Pope Janetbirdope ( View Tweet)
Bariatric surgery decreases the risk of moderate-to-severe hip or knee osteoarthritis.
Burkard. OP0106
#EULAR2021 > FB https://t.co/qh1RQfcvM2
ARD & RMD Open ARD_BMJ ( View Tweet)
Our meta-analysis on IA GC effects on pain and function in knee OA vs. controls at different time points: short term superiority of IA GC, medium term effect is no longer significant apart vs PBO and long term IA GC non superior vs controls. #EULAR2021 @RheumNow #POS1099 https://t.co/mQ0bMF03IT
Aurelie Najm AurelieRheumo ( View Tweet)
Novartis announced that Cosentyx (secukinumab) has received FDA approval for treatment of children and adolescents with moderate to severe plaque psoriasis #EULAR2021 https://t.co/JlkmjLwqQ8
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Dr. John Cush RheumNow ( View Tweet)
Hands-Down Rheumatology - Gout doesnt get to the hands until its done its damage below (MTP, ankle, knee) and usually only in those with severe tophaceous goutdCan also present as dactylitis or Carpal tunnel. Women on diuretics w/ CKD can get gout in Nodal OA joints https://t.co/EpBpdC31J6
Dr. John Cush RheumNow ( View Tweet)
Hands-Down Rheumatology - Swollen Hands In Rheumatoid Arthritis - could be from synovitis, tenosynovitis, edema, effusion, bony hypertrophy, nodules, secondary OA. https://t.co/dRCMzgdHqf
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Dr. John Cush RheumNow ( View Tweet)
