Immune Necrotizing Myopathy

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A full read review of immune-mediated necrotizing myopathy is portrayed as a distinct subtype of inflammatory myopathies first described in 2004.

Clinical Trial Boom or Bust in Severe COVID-19

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A number of recently published clinical trials are further defining the efficacy and outcomes of tocilizumab or remdesivir in treating SARs-CoV-2 infection.

Remdesivir

Biologics Beneficial in Eosinophilic Vasculitis

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Two biologic therapies showed promise in the treatment of refractory or relapsing eosinophilic granulomatosis with polyangiitis (EGPA) in a retrospective European study.

Sustained Remission Off Therapy Unlikely in GPA

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A French Vasculitis Study Group analysis of their granulomatosis with polyangiitis (GPA) reveals that after 10 years, only 7% of GPA patients achieved sustained remission off therapy (SROT) and have never relapsed.

Systemic Steroids Reduce Mortality in COVID-19

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JAMA Internal Medicine reports an analysis of COVID-19 clinical trials showing that critically ill patients with COVID-19 treated with systemic corticosteroids have an overall lower mortality rate.

RheumNow Podcast – Cardiovascular Risk in Psoriatic Disease (9.25.20)

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Dr. Jack Cush reviews the news and Journal articles from the past week on RheumNow.com.

EULAR Updated 2019 Recommendations for Psoriatic Arthritis Management

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In June 2020, we failed to report on the ARD publication updating the 2019 update the European League Against Rheumatism (EULAR) recommendations for the pharmacological treatment of psoriatic arthritis (PsA) - these are presented below.

ACR 2020 Reproductive Guidelines - Lactation Guidance

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In this third excerpt from the ACR guidelines on managing reproductive health issues in rheumatic disease patients, we present recommendations regarding the use of glucocorticoids and guidance on lactation and medication use post-partum.

RheumNow Podcast – To Celiac Test or Not? (9.4.20)

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Dr Jack Cush reviews the news, journal articles and takes a few Back Talk questions this week:

Treatment Options for Extraintestinal IBD

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Extraintestinal manifestations (EIMs) frequently accompany inflammatory bowel disease, often augmenting morbidity and mortality are associated with disease activity and may increase the need for surgery or treatment escalation.  A recent review in GUT details the treatment options for patients with EIM.

Steroid Bursts and Adverse Events

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Annals of Internal Medicine has published a population based study showing that the use of (short term) corticosteroid bursts were associated with GI bleeding, sepsis, and heart failure, often occurring within the first month of steroid therapy. 

RheumNow Podcast – Rheum Lives Matter (8.28.20)

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Dr. Jack Cush reviews the news and journal articles from the past week. Of mice and men in cartilage, the efficacy of JAK inhibitors in patients who are having skin problems, nrAxSpa has its own diagnostic code, metformin, talking about Back Talk, plus so much more.

Update on Polymyalgia Rheumatica and Giant Cell Arteritis

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JAMA has published a clinical update of recent studies on GCA. While PET/CT scanning are novel means of demonstrating activity, they have not changed the diagnostic approach to GCA or PMR and although there are no new proven treatment strategies for PMR beyond glucocorticoids, the FDA has approved tocilizumab as a first-line glucocorticoid-sparing agent.