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English for the Biologically-Challenged (8.4.2023)

Aug 04, 2023 6:00 am

Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com.  This week highlights Veterans, Vegetarians and Antenatal Corticosteroids.

  1. RABBIT Registry Study 2470 pts (1,245 axSpA; 1,225 PsA) - moderate depressive Sxs in 8% & 21% w/ severe Sxs. Depressive Sxs were assoc w/ fatigue, not engaging in sports, & greater functional limitation - may affect perception of disease activity https://t.co/XTyzLF98BC
  2. Spinal CT study of 40 ankylosing spondylitis pts shows the most common site and region of intervertebral fusion were the posterior vertebrae of the middle thoracic region >50% halffused posterior vertebrae Th4–Th5 to Th7–Th8, followed by Cx, last lumbar https://t.co/Zxchr4yUGI
  3. Vegetarians have a significantly higher hip fracture risk (HR 1.50) than regular meat-eaters, partly (28%)explained by BMI. UK Biobank compared meat-eaters (n=regular 258,765, occasional 137,954), pescatarians (9557), & vegetarians (7638) https://t.co/EyL1PPpfYE
  4. High mortality risk predictors in patients with anti-MDA5 dermatomyositis include: - rapidly progressive interstitial lung disease - anti-Ro52 antibody - age > 57 years (based on study of 126 MDA-5+ DM pts) https://t.co/VCyLhStFgX
  5. Hong Kong study shows Very low dose prednisolone (<5 mg/d) doesn't confer excessive CV risk. 2 233 RA pts (105 826 Pt-years FUV; mean duration 8.7 yrs) - 7% developed MACE. MACE risk incr 7% per month in those taking ≥5 mg pred. https://t.co/lcehOgaqCQ
  6. Study of Veterans, Medicare, Medicaid RA pts (73070) pts, matched 1:10 w/ non-RA (639268) looked at aortic valve Dz risk; RA pts have incr risk incident AS (adj HR 1.48), aortic valve surgery (aHR 1.34) & AS-related death (aHR 1.26). AS incidence=3.97/1000PYs https://t.co/rvA59hn6FE
  7. Synovial T cells from 20 pts Rx w/ immune checkpoint inhibitors who developed ICI-arthritis compared w/ synovial T cells from RA & PsA pts - showing clonal expansion of activated effector CD38hi,CD127−, CD8 T cells, w/ incr type I IFN-assoc transcripts https://t.co/vw2sOGL6jQ
  8. New Full Length from A&R: A Double-Blind, Randomized, Placebo-Controlled, Phase 2 Trial of Obexelimab in Systemic Lupus Erythematosus with Exploration of Response Based on Gene Pathway Co-Expression Patterns https://t.co/5pzBfiZaNt Created with https://t.co/L5O6lHuNSY
  9. Spanish study of 518 #SLE patients, 7% of whom received at least one dose of rituximab(26) or belimumab (11). RTX given for either hemolytic anemia or ITP (11 pts), nephritis & CNS SLE (5 pts ea). BEL mostly for arthritis (8 pts) https://t.co/IqCVfOL5rb
  10. Retrospective study of 1877 pts. W/ granulomatosis with polyangiitis (GPA) on RTX found only 23% received TMP-SMX for a median of 141 days. Prophylaxis was assoc w/ prednisone use (OR 3.96), MTX use (OR 1.48), ICU care (OR 1.95), hospitalization(OR 1.56) https://t.co/JRUC8HUwJU
  11. Antenatal Corticosteroids and Serious Infection in Offspring
  12. 2023-2024 Best Rheumatology Hospitals
  13. "Ask Cush Anything"  -  What is your effective treatment for rheumatoid Nodules?
  14. Bringing pivotal clinical trials to you: RheumNow’s Poster Hall

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Disclosures
The author has no conflicts of interest to disclose related to this subject