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Knee Replacement in Obese OA is Cost Effective

Jack Cush, MD

Debates over ideal candidates for total knee replacement (TKR) in osteoarthritis patients often excludes those who are obese, but a recent article in the Annals of Internal Medicine suggests that TKR is both effective and cost-effective in obese patients (BMI >40 kg/m2) with

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EULAR Guidelines on Intraarticular Therapy

Jack Cush, MD

EULAR has published evidence-based recommendations on the use of intra-articular therapies (IAT) based on the literature review and recommendations of a multidisciplinary international task force. These IAT recommendations apply to adult patients with peripheral arthropathies.

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TAA, TAR, Ankle, replacement

Total Ankle Arthroplasty vs. Arthodeisis?

Jack Cush, MD

 The Journal of Bone & Joint Surgery reports the findings of a 4-year trial comparing outcomes of total ankle arthroplasty (TAA) versus ankle arthrodesis (AA) in patients with severe ankle arthritis; finding that while both groups improved, TAA was associated with less pain and better function after 4 years.

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OA, erosive, inflammatory, DIP

Severity Associated with Erosive Hand Osteoarthritis

Jack Cush, MD

Erosive hand osteoarthritis (EHOA) was studied as part of the Osteoarthritis Initiative, and shown to increase with advanced age and female sex, with developmental findings to suggest that EHOA as a disorder of skeletal frailty.

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NSAID Safety with COVID-19 Infection

Jack Cush, MD

NSAIDs do not affect COVID outcomes; here we are nearly 16 months into the pandemic, and this is the common sense conclusion of a recent trial published in Lancet Rheumatology.

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Higher rate of Parkinsonism in Osteoarthritis? Taiwan Health Insurance claims analysis of 33,360 OA pts (age 50-64 yrs) vs age matched non-OA - found incr risk of Parkinsons in OA pts (aHR=1.41), esp in knee or hip OA (aHR 1.55) group. https://t.co/SHudF5NnwH

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Dr. John Cush RheumNow ( View Tweet)

Stroke risk is increased in arthritis (RR 1.36, 95% CI: 1.27–1.46); esp for RA (RR 1.38), AS (RR 1.49), PsA (1.33) & gout (1.40); but NOT osteoarthritis (RR=1.03). Apparently Inflammation drives this risk. https://t.co/Snb6OrtZJH

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Dr. John Cush RheumNow ( View Tweet)

Don't Kill the Krill! Dr. Kathryn Dao ( @KDAO2011) reviews abstract POS0276 regarding the efficacy of krill oil in knee OA, presented at the virtual EULAR 2021 meeting. https://t.co/gX2hivyCs2 https://t.co/QaU7A7gM8j

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Dr. John Cush RheumNow ( View Tweet)
Time to go raspberry picking? Rubus idaeus leaf extract 400mg and 200mg after 12 weeks ⬇️ VAS pain in knee OA compared to placebo ⭐️no effect on WOMAC, SF-36, 20m walking Abs#POS0281 #EULAR2021 @RheumNow https://t.co/QAiag2XjRh
Robert B Chao, MD doctorRBC ( View Tweet)
A single dose of LORECIVIVINT IA (Wnt pathway modulator) in Phase 3 study in knee OA: mild improvement of WOMAC pain -8.16[-15.60, -0.71] P=0.032 and function -9.47[-17.09, -1.84] P=0.015 at 6 and 12months with no particular safety signal. #POS0278 #EULAR2021 @RheumNow https://t.co/5qQE6MPjnU
Aurelie Najm AurelieRheumo ( View Tweet)
Sounds fishy! Krill oil in #osteoarthritis is not a good catch! Fully neg RCT POS0276 @eular_org @RheumNow #EULAR2021 https://t.co/OGZbltDyxg

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Janet Pope Janetbirdope ( View Tweet)

Bariatric surgery decreases the risk of moderate-to-severe hip or knee osteoarthritis. Burkard. OP0106 #EULAR2021 > FB https://t.co/qh1RQfcvM2
ARD & RMD Open ARD_BMJ ( View Tweet)
Our meta-analysis on IA GC effects on pain and function in knee OA vs. controls at different time points: short term superiority of IA GC, medium term effect is no longer significant apart vs PBO and long term IA GC non superior vs controls. #EULAR2021 @RheumNow #POS1099 https://t.co/mQ0bMF03IT
Aurelie Najm AurelieRheumo ( View Tweet)
Novartis announced that Cosentyx (secukinumab) has received FDA approval for treatment of children and adolescents with moderate to severe plaque psoriasis #EULAR2021 https://t.co/JlkmjLwqQ8

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Dr. John Cush RheumNow ( View Tweet)

Hands-Down Rheumatology - Gout doesnt get to the hands until its done its damage below (MTP, ankle, knee) and usually only in those with severe tophaceous goutdCan also present as dactylitis or Carpal tunnel. Women on diuretics w/ CKD can get gout in Nodal OA joints https://t.co/EpBpdC31J6
Dr. John Cush RheumNow ( View Tweet)
Hands-Down Rheumatology - Swollen Hands In Rheumatoid Arthritis - could be from synovitis, tenosynovitis, edema, effusion, bony hypertrophy, nodules, secondary OA. https://t.co/dRCMzgdHqf

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Dr. John Cush RheumNow ( View Tweet)

Hands-Down Rheumatology - Erosive hand osteoarthritis (EHOA) affects 2.6% of knee OA pts (from Osteoarthritis Initiative) Risk factors - older [RR 0.76), female (RR=1.73), greater OA severity, and "thinner bones" https://t.co/3s8E4F6QDR

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Dr. John Cush RheumNow ( View Tweet)

Popular Read: Little Effect with Multimodal Treatment of CMC1 Osteoarthritis https://t.co/6SnJYOK6nu https://t.co/ldTQRujshq

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Dr. John Cush RheumNow ( View Tweet)
Severity Associated with Erosive Hand Osteoarthritis EHOA was studied as part of the Osteoarthritis Initiative, and shown to increase with advanced age and female sex, with developmental findings to suggest that EHOA as a disorder of skeletal frailty. https://t.co/3s8E4F6QDR https://t.co/xiDb0LGhCv

Links:

Dr. John Cush RheumNow ( View Tweet)
New download available! Osteoarthritis vs. Rheumatoid Arthritis https://t.co/qvVEcKqNAM https://t.co/3f8sRSgyQo

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Dr. John Cush RheumNow ( View Tweet)
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