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RheumNow Podcast – Uppers and Downers

Apr 30, 2021 2:58 pm

Dr. Jack Cush reviews the news and journal reports from the past week on

  1. MMWR CDC study shows that adults >65yrs who are fully vaccinated (w/ Pfizer or Moderna) showed 94% drop in COVID-19 hospitalization (64% for among partially vaccinated adults)

  2. Gout Prophylaxis in patients with severe CKD? Metanalysis of 33 studies suggests 1) lack of good data guidance; 3) Colchicine is associated w/ toxicity w/ CKD (neuromyopathy, rhabdomyolysis; 3) anakinra - works, expensive, little/no toxicity

  3. Analysis of Taiwans National Health Insurance Database, shows from >4.5 million children (<18yrs), 23% received steroid burst < 14 days (URI, allergies, asthma) and shows higher 30 rates of GI Bleed (IRR 1.4), Sepsis (2.02), & pneumonia (2.19)

  4. Hydroxychloroquine related hyperpigmentation appears as Blue or black discoloration of skin or mucosa, occurs in 7-30%; Recent report says ~5%; Risk factors include steroids, bruising, anti-coagulants and trauma - theyr slow to resolve if you D/C

  5. Golimumab Effective in non-radiographic Axial Spondyloarthriti

  6. Little Effect with Multimodal Treatment of CMC1 Osteoarthritis 

  7. Dual IL-17 Targeting is Effective but has More Candidiasis

  8. Tofacitinib in Ankylosing Spondylitis

  9. ACR Updates COVID-19 Vaccine Guidance- April 2021   

  10. Tuesday Nite Rheumatology – Highlights from RNL 2021 – Advance in RA 

  11. BACK TALK – Rheums, got a Rheumatology question or case for Jack Cush? Record it here and we'll feature it on an upcoming podcast. Tell us your name and where you practice rheumatology. 

The author has received compensation as an advisor or consultant on this subject

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