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Ozempic will change rheumatology

d David Liew, FRACP

Many of our diseases are made worse by obesity, notably rheumatoid arthritis, psoriatic arthritis, and osteoarthritis. Much of the refractory pain and suffering from these conditions might be attributable to obesity, so active questions will be raised about how GLP-1 agonists can influence the diseases we treat.

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Off-Label Use of JAK Inhibitors in Orphan Diseases and Other Conditions?

d Janet Pope, MD, MPH, FRCPC

When should you consider off-label use of JAKi?

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Novel TYK2 inhibitor Zasocitinib

d Brian Jaros, MD

Similar to JAKs, TYK2 is an important mediator of innate and adaptive immune activation. Unlike JAKs, however, TYK2 is thought to play a minimal role in other pathways, such as metabolic and hematopoietic axes. Therefore, it is hypothesized that TYK2-targeted agents could be effective in rheumatic disease, with a potential for less off-target adverse effects. Zasocitinib is a new, oral TYK2 inhibitor generated using artificial intelligence-assisted compound design.

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Diagnostic Delays in PsA

d Caoilfhionn Marie Connolly, MD

Despite the remarkable expansion of the therapeutic armamentarium for psoriatic arthritis (PsA), the MONITOR-PsA study highlights a persistent and critical issue: delays in diagnosis. The study findings are stark, with about 25% of patients having erosions at diagnosis.

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​​Standardizing Still’s Disease Research: Global Data Harmonization Needed

d Bella Mehta, MBBS, MS

A recent study presented at #ACR24 convergence highlights significant gaps and inconsistencies in the research of systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still’s disease (AOSD).

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What Lies Beneath: Understanding Nailfold Capillaroscopy Capillaroscopy is a non-invasive imaging technique used for the in vivo assessment of the microcirculation. It can be performed using various optical instruments, but only the dermatoscope and videocapillaroscope have… https://t.co/JK9EvuxWEV https://t.co/77AcwfKIzE
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Cyclophosphomide vs Mycophenolate vs Tacrolimus in Lupus Nephritis Dr. Mike Putman discusses abstract 0670, presented at #ACR24. https://t.co/QiWdioliDi https://t.co/DPRA58vyUn

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ANA+ and no Autoimmune Disease? Check the liver Dr. Janet Pope discusses abstract 0627, presented at #ACR24. https://t.co/4HV2kqjibL https://t.co/kmVcvUZtRQ

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Dreaming of Relief: The Importance of Sleep in Lupus and Rheumatoid Arthritis Sleep is crucial for managing inflammation and health. In rheumatic diseases like lupus and RA, disrupted sleep is common and can worsen symptoms and disease progression. Experts stress the importance… https://t.co/u3DmSdaoVN https://t.co/ncMX3uhOMw
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#ACR Best 2024 - Day 4 Although the last day of #ACR24 was but a half day - it was chock full of gems, many coming from the late breaking abstracts presented today. As chosen by the RheumNow faculty, here are some highlight presentations you need to know about.… https://t.co/GseDW1ZfkL https://t.co/35aJs0yG8i
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The Psoriatic March: PsA before PsO https://t.co/lRCrzdKX7Z https://t.co/eabYe3GXrM

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Worried about CV Risk and JAKi? What about the Steroids? Dr. David Liew discusses abstracts 1981 and 2673, presented at #ACR24 https://t.co/OkMgIqxl2A https://t.co/1DVapGcWUn

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#ACR24: What I learned in Sjogren's, Takayasu's and CAR-T Dr. Janet Pope reviews abstract 2527 and abstract 1696. https://t.co/rrrGnOhfIV https://t.co/Ht1UTtYOLI

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What's New in Relapsing Polychondritis? Dr. Bella Mehta discusses abstract 2649 presented at #ACR24. https://t.co/4ibGOFzTAG https://t.co/fnvp1m1nS8

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A useful urinary biomarker for lupus nephritis Dr. Andrea Fava discusses plenary abstract 1642, presented at #ACR24 https://t.co/5kFXUn3xlF https://t.co/mWTX9SbDGm

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Is Frequent Lab Monitoring Necessary? Dr. Bella Mehta discusses abstract 2619, Safety Outcomes of Routine Blood Tests for Monitoring of Biologic and Targeted Synthetic Therapies in Inflammatory Arthritis Patients, presented at #ACR24. https://t.co/vwPueeAVhO https://t.co/5wyTahjMAu

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Maximizing DMARDs to Strive for Steroid-Free Remission in RA In 1950, three scientists won the Nobel Prize for discovering steroids, initially hailed as a "miracle cure" for RA. However, within a year, unrelated side effects like pain and fatigue emerged. Despite these issues,… https://t.co/dQEjXzxU0U https://t.co/NqyZHfBiId
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#ACR24 BEST Abstracts from Day 3 https://t.co/CQ3FxPKfxQ https://t.co/aIQdDhYYMj

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Anti IL-17 on Entheseal Biopsy in PsA Dr. Eric Dein reports on abstract 2586, presented at #ACR24 https://t.co/2JCFnB8HNq https://t.co/2MFCiNnvj2

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Cumulative Steroid Use and Cardiovascular Events Dr. Mrinalini Dey abstract 1719, Cumulative Glucocorticoid Exposure and Major Adverse Cardiovascular Events in a Cohort of Veterans with Rheumatoid Arthritis: A Nested Case-Control Study, presented at #ACR24.… https://t.co/DqkDgOwsP9 https://t.co/RXRU05UPoh
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