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RheumNow Week in Review – 16 December 2016

Dec 16, 2016 11:18 am

Dr. Jack Cush reviews highlights from this week on RheumNow.com

  1. US Life expectancy fell from 78.9 in 2014 to 78.8 in 2015. This is the first drop in 22 yrs; due to rises in 8/10 leading causes of death https://t.co/gfTYUem2BY
  2. Reports on Overuse of medical care doubled in last Yr. Overuse of specialty referrals, hospitalizations, narcotics overuse, testosterone use https://t.co/UHHMxoRaoY
  3. JAMA Internal Medicine reports 1/6 Americans used a psychiatric drug in 2013; higher in older people, women and whites. https://t.co/tCkR9FwVgB
  4. Among 618 PsA patients; 1/2 Rx with a TNFi and 1/2 Rx with DMARDs. Found subsequent Cancer event rates (0.52 vs 1.0/100PY) were significantly lower with the TNFi http://buff.ly/2hPsHgp
  5. PPP Syndrome: Pancreatitis, Panniculitis & Polyarthritis is rare & occurs with pancreatic CA or pancreatitis; Biopsies show panniculitis +/- fat necrosis http://buff.ly/2hCbtUl
  6. 40 Scleroderma patients reported with either very large pericardial effusions (1/3) or pericardial tamponade (2/3); Fluid was exudative. Treatment included. Steroids 50% or surgery 32% https://t.co/bgSdeH0urn
  7. How to ask the Alopecia question Correct: "Is there hair on the pillow in the morning". Less Correct/Specific: "is there hair on the brush or in the shower"
  8. PNAS report of 21 patients with chronic mucocutaneous Candidiasis due to autosomal recessive IL-17RA deficiency, starts infancy with Staph & Candida infections buff.ly/2hB4lLb
  9. IL-33 could be a biomarker for RTX responses – when RA pts are RF+ or CCP+; and have detectable serum IL-33 levels & High IgG levels a 100% EULAR response was seen. https://t.co/meig18rSEX
  10. Study of 219 pregnant IBD pts shows TNF inhibitor use during Pregnancy was not associated with adverse pregnancy or fetal outcomes https://t.co/tk023yiftP
  11. Over 1000 RA patients with resolved HBV (HBsAg -/HBcAb+) infection it was shown that the reactivation rate was 1.9 per 100Pt-Yrs; and not higher with MT or DMARD use https://t.co/0bJA0oF8tp
  12. Rituximab May Reduce Mortality Risk in Rheumatoid Lung Disease
  13. Lupus May Be at Increased Risk for Dementia
  14. Random Drug Levels and Anti-Drug Antibodies Predict Rheumatoid Outcomes 
  15. EULAR 2016 Recommendations on Early Arthritis
Disclosures
The author has received research/grant financial support on this subject
The author has received compensation as an advisor or consultant on this subject

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