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The RheumNow Week in Review – 21 July 2017

Jul 21, 2017 7:34 am

Dr. Jack Cush reviews the news from the past week on RheumNow.com: 

  1. FDA accepts Pfizers NDA for Xeljanz (tofacitinib) as treatment for moderately to severely active ulcerative colitis https://t.co/QJi2g2Bfao
  2. FDA rejects Romosuzumab (anti-Sclerostin OP Rx) w/ a complete response letter asking for resubmission, more data https://t.co/Xz8DjEMtUM
  3. RA ACPA+ have higher economic burden with MORE early DMARD use (71 vs 50%) & Biologic use (20 vs 12%); more MD visits; & more Total costs https://t.co/le0vgHKaPL
  4. Mucosal immunity seen in at-risk RA (preclinical) people who had more IgA producing plasmablasts (39%) than established RA or normal controls(1%, 9%) https://t.co/Bi9F2inrtb 
  5. 7 patients with Active Refractory Takayasu arteritis treated with RTX showed mixed results - 3 achieved remission but 4 failed to respond to RTX. https://t.co/rXSNc6qpTn  
  6. Study of 38,924 shows dairy intake assoc with an increased risk of OA hip replacement (unrelated to age, BMI, smoking, activity https://t.co/T37NXzn40B
  7. 1979-2013 Septic arthritis in RA has increased and associated with more biologic use, polyarticular infections, MRSA (6% v 31%); but same outcomes https://t.co/2JNqp5n1GJ
  8. Alcohol & Smoking assoc w/ 2 fold risk of Hand OA. but being overweight or obese is NOT. https://t.co/pAa2uiLa9B
  9. MTX has yet to be shown to benefit Osteoarthritis; but there is a new PROMOTE trial looking at pain reduction. Still enrolling. https://t.co/yc3qSEPujJ
  10. Zurampic 200mg + Uloric fails vs Uloric alone at achieving two primary endpoints SUAhttps://t.co/LtjJyKIQ28
  11. Adverse Maternal and Fetal Outcomes in Lupus - and Pre-Lupus Too 
  12. Acute Coronary Syndrome Increased in Early Rheumatoid Arthritis 
  13. Long-Term Additive Cardiovascular Benefit of Plaquenil and Aspirin in Lupus 
  14. FDA Approves Tremfya (guselkumab) for Plaque Psoriasis

 

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