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Fitbit

From Fitbit to first diagnosis: AI is rewriting the RA playbook

d Mrinalini Dey, MD

Artificial intelligence isn’t a distant frontier anymore. It’s here, and it appears able to detect signs of rheumatoid arthritis, possibly before we can clinically detect it. Two studies presented at this year’s ACR meeting highlight just how close we may be to a future where algorithms flag disease before we can and monitor activity with minimal patient burden.

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pregnant, pregnancy, mother, fertility

New Insights into Pregnancy Outcomes and Maternal-Fetal Health in Rheumatic Diseases

d ACR Press Release

At ACR Convergence 2025, the American College of Rheumatology presents new research illuminating critical challenges and advances in pregnancy outcomes for women living with rheumatic diseases, including axial spondyloarthritis, antiphospholipid syndrome, and lupus.

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CAR-T

CAR-T Cell Therapies Show Promise for Autoimmune Disease at ACR Convergence 2025

d

Two pioneering studies presented at ACR Convergence 2025 spotlight the potential of CAR-T cell therapies to transform treatment for systemic lupus erythematosus (SLE) and other autoimmune diseases.

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Kidneys small

Sooner May Still Be Too Late: Kidney Biopsies in SLE

d Michael Putman, MD, MSCI

ACR Convergence 2025 will be kicking off with a Plenary Session by Michelle Petri (Abstract 0772: Redefining When to Biopsy the Kidney in Patients with SLE), which is a great place to kick off our coverage of the meeting. As part of a collaboration with the Accelerating Medicines Partnership, Petri and colleagues have given data to what many of us have long suspected: a biopsy threshold of 0.5g/d of proteinuria may be too high.

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Sleep asleep

Sleep Apnea in Psoriatic Arthritis – A Wake Up Call

d Antoni Chan, MD, PhD

Fatigue is one of the most disabling symptoms in psoriatic arthritis (PsA), yet its causes are often underexplored. At ACR 2025, Abstract #0549, a possible hidden contributor was studied: obstructive sleep apnea (OSA).

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Red puzzle piece

New pieces added to the Pre-RA puzzle

d Aurelie Najm, MD, PhD

We know that pre-RA is a definition that stands under a large umbrella, ranging from asymptomatic individuals with ACPA positivity to individuals with symptomatic pre-clinical synovitis. How can we predict the transition from the at-risk state to clinical RA outside the realm of clinical, conventional serological (RF/anti-CCP) or imaging (US/MRI synovitis) biomarkers?

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ANCA, vasculitis, test

Mimics of ANCA-associated vasculitis: How can we tell?

d Brian Jaros, MD

With increased disease awareness and more regular, accessible testing for anti-neutrophil cytoplasmic antibodies (ANCA), ANCA-associated vasculitis (AAV) has become an increasingly recognized clinical entity in rheumatologic practice. 

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Year in Review: Regency Trial showed that LN pts given obinutuzumab achieved CRR at 76 wks (46.4%) vs. PBO. Take note: the Regency trial did not evaluate the extrarenal effects of Obinutuzumab in #SLE, thats for a diff study. #ACR25 @RheumNow https://t.co/WJssU1DbzZ

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sheila RHEUMarampa ( View Tweet)
High-resolution ultrasound detected subclinical enthesitis in 44% of psoriasis patients without arthritis and 12% had PD positivity. Supports a preclinical PsA phase and use of MSUS to detect entheseal inflammation in both symptomatic and asymptomatic PsO patients for timely

Antoni Chan MD (Prof) synovialjoints ( View Tweet)

#ACR25 New ACR Non-Renal #SLE lifecourse Guideline. 3 strong recommendations: - HCQ routinely unless contraindicated - Taper GC to =< 5mg/d - Escalate therapy in any organ system if refractory to initial therapy *Organ-specific: Conditional recommendations only @RheumNow https://t.co/w9rfcvwGHy

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Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Don’t fight #AI #RCTs - #AI better at soft Skills alone Vs #Medical input and AI as we tend to Disbelieve the model & mess it up! #LLM can accurately take a #history Bottom line EMBRACE AI ?check it too #ACR25 @RheumNow @ACRheum #artificial #intelligence and #medicine 26217 https://t.co/22MYD4QqzH

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Janet Pope Janetbirdope ( View Tweet)
@ACRheum SLE Treatment Guidelines 2025 Key points: - HCQ is standard - steroids with precision - immunosuppressive therapies early - shared decision making #ACR25 @RheumNow https://t.co/AYIXE6dLlW

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David Liew drdavidliew ( View Tweet)
Saphnelo (anifrolumab) has been recommended for approval in EU by CHMP for systemic lupus erythematosus (on top of standard therapy) as a once-weekly pre-filled pen. Recommendation based on TULIP-SC Phase III trial. https://t.co/UurvtLNP7S https://t.co/xeKVdVYu3z

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Dr. John Cush RheumNow ( View Tweet)
Wondering whether rheumatology is the specialty for you? Dr Bryant England kicks off the clinical science #YearInReview with an impressive overview of what a year in rheumatology looks like. New drugs, new devices, new disease names! 🤯 #ChooseRheumatology #ACR25 @RheumNow https://t.co/uLrNFPgeAn

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Mrinalini Dey DrMiniDey ( View Tweet)
#Sjogren disease is here to stay. “The name has caught up to the science of SD and this can translate to better treatment outcomes for patients” - Dr. Bryant England #ACR25 @RheumNow https://t.co/M4r0XXkswv

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sheila RHEUMarampa ( View Tweet)
Basic Sci Year in Review: Dr. Anne Davidson discusses the potential pathologic link bet tryptophan, indole, I3S & IL-17 pathways. I3S induces epidermal thickening in mice and correlated with dse activity in patients with #psoriasis #ACR25 @RheumNow https://t.co/WNNbBBESQ3

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sheila RHEUMarampa ( View Tweet)
Rheum guidelines balance data & context. Beyond evidence, factors like cost, equity & feasibility shape recs. GRADE-ADOLOPMENT = global tool to adopt, adapt, or design local guidance for more rapid integration and with less $$$ @RheumNow #ACR25 #GlobalRheumSummitt https://t.co/Sfsqxsqpt4

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Jiha Lee JihaRheum ( View Tweet)
RheumNow’s expanded coverage of the #ACR25 Annual Meeting is sponsored by Bristol Myers Squibb, Novartis, and UCB. All coverage content is independently selected by RheumNow and its faculty.

Dr. John Cush RheumNow ( View Tweet)

12 yr study of 115 Systemic Sclerosis pts shows Finger-to-palm distance (tip 4th finger to distal palmar crease) may be a useful tool for predicting the progression of skin thickening and the development of digital ulcers in the early stages of severe SSc https://t.co/brCEz5Fqac https://t.co/kZMQ0UsimB

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Dr. John Cush RheumNow ( View Tweet)
From Eye on Cytokine Storm- Decoding MAS by Dr Grant Schulert : “IL-18 is highly elevated in SJIa and other autoinflammatory disorders…can amplify innate signaling as well as induce IFN-gamma”. @RheumNow #ACR2025 https://t.co/6e5yfeDepX

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Gabriela Martinez Zayas, MD MartinezZayasMd ( View Tweet)
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