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Shifting the Management Paradigm for SLE and Lupus Nephritis

Karen Costenbader, MD, MPH

The paradigm for treating patients with systemic lupus erythematosus (SLE) is rapidly shifting and our patients will surely benefit with improved outcomes.

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Moving Targets in Lupus and Lupus Trials

Joan T. Merrill, MD

Clinical trial data quality is a moving target. Lupus is also a moving target. Can we address the moving target of lupus pathology with the moving targets of quality clinical trials and scientific treatment selection?

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Is Lupus Just a B Cell Disorder?

I'm very happy to give you some insights entitled, “Is Lupus a B-Cell Disorder”. I will review some aspects, mainly pros and cons, but at the end you may forgive me, I will escape a little bit from a clear yes or no.

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Steroids in Lupus Nephritis: No Free Lunch

Michael Putman, MD, MSCI

Today I'm here to talk with you about steroids in lupus nephritis. The impetus for this is the 2024 ACR guideline for the management of lupus nephritis.

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SLE, Antiphospholipid Antibodies, and the Placenta

Catherine Sims, MD

It is well established that women with SLE are at increased risk for adverse pregnancy outcomes, including preeclampsia, preterm birth, and pregnancy loss. However, the pathophysiologic mechanisms driving these complications are not yet fully understood. In this article, we explore several proposed pathways where the immune system and placenta interface, summarized in Figure 1, that may enhance our understanding of these risks.

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Lupus Clinical Slides: Set 1 https://t.co/zFQqHfl8Ch https://t.co/MBzsixwhQc

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Dr. John Cush RheumNow ( View Tweet)
QD Clinic - Tackling Lupus Pregnancies Managing Lupus Pregnancy - pre-pregnancy, labs & safe drugs https://t.co/rtDVCCVqnD https://t.co/IRi1qYYqAA

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Dr. John Cush RheumNow ( View Tweet)
Panacea of Prednisone & Cannabis (5.16.2025) Dr. Jack Cush reviews the news, journal and regulatory reports from this week on RheumNow. Interesting trends and results with prednisone in lupus, cannabis in RA and opioid deaths too! https://t.co/QDtxItYSco https://t.co/s4nYmMe3vs

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Dr. John Cush RheumNow ( View Tweet)
SLE, Antiphospholipid Antibodies, and the Placenta It is well established that women with SLE are at increased risk for adverse pregnancy outcomes, including preeclampsia, preterm birth, and pregnancy loss. However, the pathophysiologic mechanisms driving these complications https://t.co/f8Up1112m9
Dr. John Cush RheumNow ( View Tweet)
Lupus QD Clinic - Rhupus dsDNA+ SLE Plus CCP+ RA = Rhupus https://t.co/lyV7fgd1vp https://t.co/IKkS0enQH9

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Dr. John Cush RheumNow ( View Tweet)
Lupus in an empty house The full house immunofluorescence pattern is the classic histopathologic finding of lupus and lupus nephritis. Glomerular deposits staining for IgG, IgA, IgM, C3 and C1q can help confirm a suspected diagnosis of systemic lupus erythematosus (SLE). This https://t.co/DQWwRJmdqM
Dr. John Cush RheumNow ( View Tweet)
Assessing and Treating CV Risk Increases in Systemic Lupus For nearly 50 years, the heightened CVD risk in SLE patients has been acknowledged since Urowitz et al.'s 1976 study on lupus mortality. Research consistently shows SLE patients have a 2-10 times higher CVD risk than https://t.co/P1AdxHkiQi
Dr. John Cush RheumNow ( View Tweet)
Emulation trials in SLE: Real or Fake? Recently a landmark paper was published in A&R studying the results of an emulation trial. My colleagues and I were able to write an editorial on this paper and describe emulation trials. https://t.co/0ulYG5xz0J https://t.co/y2jo2SSH83

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Dr. John Cush RheumNow ( View Tweet)
SLE Perspectives: Past, Present, Future https://t.co/ggYmVvEtZx https://t.co/VriDjAEcl5

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Dr. John Cush RheumNow ( View Tweet)

Comparing EULAR (2025) and ACR (2020) Guidelines on Safety of Lupus Medications in Pregnancy Attendees at the 2025 RheumaPreg meeting were excited to discuss the newly released EULAR recommendations for use of antirheumatic drugs in reproduction, pregnancy, and lactation. https://t.co/csd0FE08ZO

Dr. John Cush RheumNow ( View Tweet)
New Steroid Rules in Lupus? Let’s Talk. Dr. Michelle Petri breaks down the latest strategies to minimize steroid exposure while managing disease activity in lupus patients. 💡 Smarter steroid use = better outcomes. 👉 Watch now on RheumNow: https://t.co/vbjrXAlixz #Lupus https://t.co/TN5EkZhbef

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Dr. John Cush RheumNow ( View Tweet)
🔓 Lupus Unlocked: Antiphospholipid Syndrome 📅 Tuesday, May 20, 2025 | 🕕 Time: 6:00 PM CT | 7:00 PM ET | 4:00 PM PT Live Webinar w/ Q&A Register Today: https://t.co/71NJsmBNf3 Livestream: X, LinkedIn, YouTube, Facebook This session is designed to provide practical insights https://t.co/jAtduyzl0l

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Dr. John Cush RheumNow ( View Tweet)
Clinical Impacts of the Pre Lupus State on Pregnancy Outcomes Dr. Catherine Sims talks with Dr. Jessica English at the RheumaPreg 2025 meeting in Vienna, Austria. https://t.co/T8ZYQtDNmZ https://t.co/PmVRFVlABd

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Dr. John Cush RheumNow ( View Tweet)
Deep remission in SLE – what is it, and can we achieve it? Recent reports on lupus patients treated with CAR-T cells targeting CD19+ B lymphocytes have sparked excitement. This is due to the patients experiencing ongoing clinical remission without further treatment after two https://t.co/rdBkIhfWWd
Dr. John Cush RheumNow ( View Tweet)
Lupus QD Clinic - SLE Get Ready Young SLE patient wants to get pregnant; but first she needs to get ready! Features Dr. Jack Cush https://t.co/988jrHmdUs https://t.co/qVrBU2lvI5

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Dr. John Cush RheumNow ( View Tweet)
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