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Diagnosis & Treatment of Osteoarthritis Reviewed

Jack Cush, MD

Katz, Arant and Loeser have published a comprehensive open-read overview of osteoarthritis (OA) of the hip and knee in JAMA; underscoring the impact, advances, disappointments and guidelines put forth. 

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RWCS Highlights - Day 3

Rachel Tate, DO

Day 3 report from the 2021 RWCS meeting in Maui (and virtually) includes pearls from the PsA 2020 Year in Review; fact vs. fiction on evidence based medicine: diet and rheumatic diseases; hot topics in allergy/immunology; and pediatric rheumatology highlights.

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NSAIDs in Osteoarthritis: Study Suggests Need for New Look

Jack Cush, MD

Knee osteoarthritis (OA) patients using nonsteroidal anti-inflammatory drugs (NSAIDs) showed greater loss of medial minimum joint space width than did others taking other drugs, registry data indicated.

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RheumNow Podcast – Don’t Hold the Benlysta, Take the Vaccine (1.22.2021)

Jack Cush, MD

Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com, with more than a dozen items to discuss on this week's podcast.

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Adipose Transplants as a New Regulator of Osteoarthritis

Jack Cush, MD

A novel report from PNAS suggests that in osteoarthritis (OA), the damage is not entirely from body weight and mechanics, instead it may be from adipose tissue itself.

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EULAR Guidance on Patient Adherence to Meds

Jack Cush, MD

Non-adherence may be the single most untold risk to suboptimal outcomes in the care of musculoskeletal disease.  It has been estimated that 30-80% of patients with rheumatic and musculoskeletal diseases (RMDs) are nonadherent to prescribed regimens.  EULAR has commissioned a task force

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News Feature: Diagnosis & Treatment of Osteoarthritis Reviewed Katz, Arant and Loeser have published a comprehensive open-read overview of OA of the hip and knee in JAMA; underscoring the impact, advances, disappointments and guidelines put forth https://t.co/VVnUk02KiP https://t.co/97dFC56Jcb

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Dr. John Cush RheumNow ( View Tweet)
Population based study of smoking cessation & risk of TKR in knee OA. TKR higher in recent quitters (26.7/1000PY vs 17.4/1000PY in smokers). adjusted HR=1.30 (95%CI:1.05-1.59). TKR risk was higher among quitters with weight gain (HR=1.42) https://t.co/6onQWQeFcI

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Dr. John Cush RheumNow ( View Tweet)

SF analysis usually confirms dx, but changes dx 14%. 264 SF samples showed MSU crystals in 89% gout, 9% of CPPD pts. CPP crystals found in 54% of CPPD, 43% of OA & 7% of gout pts. Ca hydroxyapatite seen 1/3 RA, 1/2 OA & 2/3 CPPD https://t.co/B8UkHagXK3 https://t.co/UTncLo6Fyu

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Dr. John Cush RheumNow ( View Tweet)
On March 24, 2021 the FDA Arthritis Advisory Committee and Drug Safety .... Committees will meet online to will discuss biologics license application, for tanezumab, from Pfizer, for the proposed treatment of moderate to severe osteoarthritis in adults https://t.co/NSlutqdHzu

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Dr. John Cush RheumNow ( View Tweet)

RWCS Highlights - Day 4 from Dr. Rachel Tate ( @uptotate) -Novel Therapies Year in Review (RA, SLE, OA) -Novel concepts in Pediatric Rheumatology -TeleRheumatology Update: Post-COVID, Pre-?? https://t.co/JoTV25suxD https://t.co/Id19zgRT37

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Dr. John Cush RheumNow ( View Tweet)
NSAIDs in Osteoarthritis: Study Suggests Need for New Look Knee osteoarthritis (OA) patients using NSAIDs showed greater loss of medial minimum joint space width than did others taking other drugs, registry data indicated. https://t.co/KNbAnNOkva https://t.co/s9mMmAR6TD

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Dr. John Cush RheumNow ( View Tweet)
QD Clinic - Chronic Monarthritis Treatment Considerations on Chronic Monarthritis https://t.co/7VmH1skHhb

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Dr. John Cush RheumNow ( View Tweet)

OpenSAFELY analysis shows that NSAIDs safe w/ COVID. Study 1: 1/2 million NSAID users vs ~2 mill non-users found no difference in COVID-19 death (HR 0.96); Study 2: 1.7 million RA/OA pts, 10% on NSAIDs had a lower risk of COVID-19 death (HR 0.78) https://t.co/1f3JBmaf2e

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Dr. John Cush RheumNow ( View Tweet)

Download Available-- Osteoarthritis vs. Rheumatoid Arthritis https://t.co/qvVEcKqNAM

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Dr. John Cush RheumNow ( View Tweet)

Denosumab inhibiting osteolysis? 22 pts undergoing revision THR surgery for osteolysis, 10 Rx w/ denosumab had 83% fewer osteoclasts @ osteolysis membrane–bone interface. Proof concept: DEN may have osteoclast effects at implant interface https://t.co/dJ06rk0SR3

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Dr. John Cush RheumNow ( View Tweet)

Results from Cohort Hip & Cohort Knee study (early symptomatic hip OA pts) finds that 1/9 went on to receive hip replacement during the 10-year follow-up. Clinical hip and Xray (ROA) OA increased over 10 yrs - ROA 19% to 49%, and clinical hip OA 27% to 43% https://t.co/AJXlkAxZiF https://t.co/PSY4ueXOsC

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Dr. John Cush RheumNow ( View Tweet)
The NEJM has featured an overview of Osteoarthritis of the Knee. https://t.co/1AaNICygOr

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Dr. John Cush RheumNow ( View Tweet)

Adipose Transplants as a New Regulator of Osteoarthritis--A novel report from PNAS suggests that in osteoarthritis (OA), the damage is not entirely from body weight and mechanics, instead it may be from adipose tissue itself. Read more: https://t.co/0VpR4VPmBX https://t.co/jSALMKXrhB

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Dr. John Cush RheumNow ( View Tweet)
Dr. Janet Pope ( @Janetbirdope) reviews Osteoarthritis studies presented at #ACR20. https://t.co/QMQ8DcsK0s https://t.co/W4w9BcsoCH

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Dr. John Cush RheumNow ( View Tweet)
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