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Erosive Hand Osteoarthritis Portends Worse OA

Oct 06, 2021 6:32 pm

An erosive hand osteoarthritis (EOA) study from the Osteoarthritis Initiative shows that EOA is more common in older women and is strongly linked to further progressive, articular structural damage.

This was a longitudinal cohort study of 3,365 individuals without prevalent erosive hand OA at baseline.

During a 48 month observation period, only 86 (2.6%) developed erosive hand OA . Risk factors for EOA included:

  • older age (RR 1.63)
  • female sex (RR 2.47)
  • Greater OA severity (sum K/L grade 13.9 versus 5.3; P < 0.001)
  • Less cortical width (1.38 mm versus 1.52 mm; P < 0.001).

After 2 years, hand EOA patients had more X-ray progression (i.e., joint space narrowing, K/L grade progression [RR 1.35], and loss of cortical thickness [RR 1.23]).

Aside from the progressive nature or EOA, those afflicted have thinner bones prior to erosive hand OA, suggesting that erosive hand OA is a disorder of skeletal frailty.

The author has no conflicts of interest to disclose related to this subject

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