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RheumNow Podcast – Like Father, Like Daughter (10.29.2021)

Oct 29, 2021 1:35 am

Dr. Jack Cush reviews the news and journal articles from the past week and discusses parent-child rheumatologists pairs.

  1. Baricitinib long-term safety in #RA - 3770 pts (14744 PYs). Incid rates/100 pt-yrs: - Serious infx 2.6 - H. Zoster 3 - MACE 0.5 - In pts ≥50yr w/ ≥1 CV risk MACE = 0.77 for 1st 2 yrs, then 0.6 - Cancer SIR 1.07 w/ low SMR 0.74 - DVT/PE risk 0.5 & 0.4  https://bit.ly/3mlJQSW

  2. Israeli study of 1497 fully vaccinated health care workers finds 39 (2.4% Breakthrough COVID infections (Jan-May 2021), most cases were mild or asymptomatic, 19% w/ persistent Sxs (>6 ws); infected had lower neutralizing Abs. https://t.co/deYTVLRQCU

  3. MMWR reports those who have recv COVID-19 vaccine have lower risk non–COVID-19 mortality (vs unvaccinated). Adjusted rel risk of non–COVID-19 death for Pfizer-vaccine (2 doses RR 0.34), Moderna (0.31), Janssen (0.54). NO INCR MORTAL RISK IN VACCINATED https://t.co/X6X1w1aYoU

  4. ACR publishes a "White paper on Antimalarial Cardiac Toxicity"- reviewing drug hx, indications, effects and rare risk of arrhythmias, conduction abnormalities, cardiomyopathy, QTc prolongation. torsade de pointes. No evidence for routine ECG monitoring https://t.co/2aemSKzk3T

  5. Short (3 min) walks intstead of sitting benefits RA w/ anticytokine effect (TNF, IL1RA), improved glucose, c-peptide, insulin. Crossover study 15 RA women who had 1) prolonged sitting, 2) 30-min mod-vigor exercise or 3) 3-min of light walking every 30 min https://t.co/36AnhHL9OI

  6. 83 patients w/ ANCA Assoc. Vasculitis, hospital admitted, 44 died in-ICU (53%) w/ death by infection (61%), active vasculitis (34%). Predictors of ICU death were APACHE II score (OR=1.3) and respiratory failure (OR=620). https://t.co/ZPBkVWy40I

  7. Rheumatic pts admitted to ICU, #SLE is most common & Sepsis most common reason. 80 ARD pts adm to ICU: Dx were SLE (42%), RA (26%), vasculitis (12%) FOR Sepsis (31%), (10%) CHF (10%). 20% died in ICU, 5% 30d after ICU, 7.5% w/in 1 yr https://t.co/lX0m3vOukI

  8. Among 825,556 sepsis pts in Taiwan (2003–2017), having SLE increased mortality risk 3 fold (HR 2.8;2.5–3.2), w/ adjustments (HR 1.47). Other risk mortality factors: age (1.02), prednisolone > 5mg/d (1.55), MTX (2.19) & immunosuppressives (1.45) https://t.co/d1OPrjgshz

  9. BEAT-LUPUS: Sequential Belimumab After Rituximab in SLE

  10. Platelet-Rich Plasma Injections Fail in Ankle Osteoarthritis 

  11. Pfizer/Lilly Pull Tanezumab Development 

  12. Like Father Like Daughter

Disclosures
The author has received compensation as an advisor or consultant on this subject

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