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New Side Effect From mRNA COVID Vaccines?

MedPage Today

Herpes zoster reactivation -- a.k.a. shingles -- following COVID-19 vaccination in six patients with comorbid autoimmune/inflammatory diseases may be a new adverse event associated with the Pfizer/BioNTech mRNA vaccine, suggested a new report.

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RheumNow Podcast – Combination Biologics

Jack Cush, MD

Dr. Jack Cush serves up this week's news and articles from RheumNow.com.

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Planes, Trains and COVID Distancing

Jack Cush, MD

MMWR reports the risk of acquiring an infection with SARS-CoV-2 is reduced 23% to 57% when the middle seat was vacant (compared with full aircraft occupancy).

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Autoimmune Risk of Death Up during COVID

Jack Cush, MD

A population-based study in the UK shows that patients with rare autoimmune rheumatic diseases (RAIRD) were 44% more likely to die during the 2020 COVID-19 pandemic (March - April) compared to either the general population or their pre-COVID risk.

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DMARD Dropouts During COVID-19

Jack Cush, MD

A full year from the onset of the SARS-COV-2 pandemic, rheumatologists are still seeing the consequences of COVID, with many patients avoiding usual care, follow-up visits, routine lab testing and with many self-stopping their antirheumatic meds, because it seemed like the right thing to do.

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RheumNow Podcast – Mistakes with Steroids

Jack Cush, MD

Dr Jack Cush gives his spin on this week's RheumNews and Rheum Research from RheumNow.com.

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Rheumatology Care Derailed by COVID-19

Jack Cush, MD

A survey study from the  ArthritisPower PPRN or CreakyJoints database shows that during the COVID-19 pandemic patient care was substantially affected in unforeseen ways.

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Reactogenicity Following mRNA COVID-19 Vaccines

Jack Cush, MD

JAMA has published the real-world reporting of mRNA vaccine side effects (reactogenicity) gathered from CDC V-safe Surveillance system and shows that local and systemic reactions were often mild and transient and most commonly seen during the first day following their second dose.

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RheumNow Podcast – Great Associations (3.19.2021)

Jack Cush, MD

Dr. Jack Cush rants on the journal reports, news and FDA actions featured this past week on RheumNow.com.

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News Feature: New Side Effect From mRNA COVID Vaccines? Herpes zoster reactivation following COVID-19 vaccination in 6 patients with comorbid autoimmune/inflammatory diseases may be a new adverse event associated with the Pfizer/BioNTech mRNA vaccine. https://t.co/GgjoIpYDkC https://t.co/sI2Fx0o05G

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Dr. John Cush RheumNow ( View Tweet)
News Feature: Planes, Trains and COVID Distancing MMWR reports the risk of acquiring an infection with SARS-CoV-2 is reduced 23% to 57% when the middle seat was vacant (compared with full aircraft occupancy). https://t.co/tGs9GopeGu https://t.co/ZRMltTpYgW

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Dr. John Cush RheumNow ( View Tweet)
Study of 26 patients with chronic inflammatory cdiseases vaccinated with mRNA vaccines showed all with considerable immunogenic responses. No unexpected side effects seen and No flares of the underlying inflammatory disease was seen. https://t.co/7Q5bYp5A9i

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Dr. John Cush RheumNow ( View Tweet)

HLA-B27 status does not change the risk of COVID-19 in spondyloarthritis patients. Survey of 3435 SpA pts; shows 76% as HLA-B27 positive. COVID infx was thesame between B27 Pos & Neg pts (1.5% vs 1.4%) and severity was also the same https://t.co/qavodFynr0

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Dr. John Cush RheumNow ( View Tweet)

#RNL2021 Coverage from @KDAO2011 "Psoriatic Arthritis Pearls by Dr. E Ruderman -MTX monoRx is effective -which TNFi does not matter -Secukinumab 300 mg is better than 150 mg dose -OK to use IL-17i in pts with FHx of IBD" #RheumNow

Dr. John Cush RheumNow ( View Tweet)

CDC updates its COVID Comorbid Dz list to include type 1 diabetes (& NIDDMA), mod-severe asthma, liver Dz, dementia , stroke/cerebrovascular disease, HIV infxn, cystic fibrosis, obesity, substance use disorders (NOT ARTHRITIS, PSORIASIS) https://t.co/LbVMVGf4IR

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Dr. John Cush RheumNow ( View Tweet)

Survey of 500 pts with systemic rheumatic diseases during the COVID-19 pandemic showed few who discontinuations Rx - 2.2% D/C for fear of immunosuppression; 3.8% for shortages (mostly HCQ); 2.6%) for resp infx and 6% for side-effects. https://t.co/2BJIYeBSIu

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Dr. John Cush RheumNow ( View Tweet)

Hydroxychloroquine studied vs Vitamin C (PBO) prophylaxis to households (n=671) exposed to COVID-19. 89% were COVD1-9 test neg at baseline. HCQ did not protect against progression to COVID (53 vs 45 events; adj HR, 1.10 [95% CI, 0.73 to 1.66]. A vit C Win! https://t.co/S5qjdIYaXq

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News Feature: Comparison of Three Coronavirus Vaccines https://t.co/omxsA8W3nQ https://t.co/s7dc9NwMQo

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Dr. John Cush RheumNow ( View Tweet)
News Feature: Rheumatic Patients Are at Risk for COVID Death https://t.co/bhJG1vuVA4 https://t.co/VEN3nwSOPB

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Dr. John Cush RheumNow ( View Tweet)
REMDACTA trial of Actemra plus remdesivir failed to meet its primary endpoint of improved time to hospital discharge for patients with severe COVID-19 pneumonia (nor its key secondary endpoints) compared to remdesivir alone https://t.co/OyqpnwUVXU

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Dr. John Cush RheumNow ( View Tweet)

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