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"You won't find IgG4-RD anywhere [in the 2012 Chapel Hill nomenclature], but it is absolutely a vasculitis"
-John Stone
#ACR22 @RheumNow
Mike Putman EBRheum ( View Tweet)
LILAC study abstracts 0364 and 0365 SLE pts w/ joint and skin activity treated with BIIB059 had consistent improvements vs PBO. More to come! #ACR22 @RheumNow https://t.co/WPl3tol7v9 and https://t.co/8cyrI3W9rD https://t.co/5W4KMOHHEA
Links:
Dr. Rachel Tate uptoTate ( View Tweet)
Need to know! Wigley says ‘each organ system has unique properties’ so ex Rx of skin may not help vasculopathy or #SSc renal crisis Rx is ACEi vs CCB in #Raynauds. 1 drug won’t be sufficient in complex diseases #13S114 #ACR22 #ACRBest @RheumNow #ClinicalPearl https://t.co/S8fHi7dFoD
Janet Pope Janetbirdope ( View Tweet)
MoA qu in GCA:
Is one JAKi better?
lab in tofa
proof-of-concept in bari
clinical trial in upa
@MdWarrington: unclear if any diff clinically
GM-CSF vs IL-17?
Maria Cid: lots of redundancy in immune system
blocking one pathway, escalation of another?
we will see
#ACR22 @RheumNow
David Liew drdavidliew ( View Tweet)
Combined pulmonary HTN and ILD seen in 7% in large scleroderma database. Unsurprisingly, survival worse then PAH/ILD alone. HAQ also worse in this group.
@RheumNow @earlyARA #ACR22 ABST1058
https://t.co/Jr58wVLC31 https://t.co/UCjKuJB1ev
Julian Segan JulianSegan ( View Tweet)
Abs 0359 TULIP-1&2 data showed nearly 10% of anifrolumab-treated pts achieved remission, suggesting that DORIS response is attainable. #ACR22 @RheumNow https://t.co/laPwd0KpSa https://t.co/6LZ1WLrc97
Dr. Rachel Tate uptoTate ( View Tweet)
Great scientific talk by John Stone, IgG4-RD should be a considered a variable-vessel disease, much like Behcet's and Cogan's syndrome
I had not viewed it from that perspective; adding it to the list! Series of patietns w/coronary involvement esp interesting
#ACR22 @RheumNow https://t.co/JUayLOTnSB
Mike Putman EBRheum ( View Tweet)
Slow pruning of Pulmonary arteries occurs way before we detect #PAH pulmonary hypertension in #scleroderma #SSc 13S114 lecture by Fred Wigley. Screen but need data re earlier Rx before Dx of PAH. May be assoc w anticentrome and +++ telangiectasia @RheumNow #ACR22 https://t.co/AgnIMYFKjB
Janet Pope Janetbirdope ( View Tweet)
#ACR22 Abstr#1464 Press Release #lupus. Should we worry of pts without nephritis & low grade proteinuria UPCR >0.2 & <0.5? A cohort study showed 50% progressed to =>0.5 at 2 yrs & 11% renal biopsy +ve. Important to monitor UPCR. Need biomarkers for this At-Risk @RheumNow #ACRBest https://t.co/eOODUynvP4
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
PCP docs managing AS?
Abstract #0078
🧑⚕️ Assessed differences in management between PCP and rheumatologists
💉RHU prescribed more biologics
💊PCP prescribed more opiate and non-opiate pain medications
💊PCP did not often prescribe csDMARDs or biologics
#ACR22 @RheumNow
Catherine Sims, MD DrCassySims ( View Tweet)
1918 influenza brought us proper design of vaccine trials as well as discovery of the influenza virus
@RheumNow #ACR22 @HRheuminations https://t.co/RlNXSWMWBz
Julian Segan JulianSegan ( View Tweet)
Please see my short review on new data and progress of BAFF/APRIL inhibition in #lupus #SLE presented at #ACR22 @RheumNow https://t.co/pqxdAcMH5e https://t.co/9IIrxVZvGe
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Ab0575 #ACR22 MI/CVA in Osteoporosis Pts on DEN/ ZOL, L Spangler
DEN pts more likely CKD, adjusted analysis
At 36 mos, risk for Den vs Zol in 2 database claims:
- MI: 0.97, 1.22 (0.8-1.7)
- CVA: 0.9 (0.6-1.2), 1.0
No incr. risk identified with Den vs Zol in MI or CVA
@RheumNow https://t.co/hgyG1ZmFLT
Eric Dein ericdeinmd ( View Tweet)
Other potential mechanisms for survival selection against the plague via MHC presentation to CD8 T cells. May be associated with SpA/HLA B27
@RheumNow @HRheuminations #ACR22 #rheuminations https://t.co/Rv117B4IYp
Julian Segan JulianSegan ( View Tweet)
Dr. Wigley describes the edematous phase of early #scleroderma:
☝️ Friction rubs are a sign of active disease and assoc. with poor outcomes
#ACR22 @RheumNow @rheumarhyme https://t.co/ooXYp1wXzu
sheila RHEUMarampa ( View Tweet)
Did you know that the first virus, the tobacco mosaic virus, was described in 1892? @AdamJBrownMD gave a fascinating lecture today regarding that included the history of viruses. #ACR22 @RheumNow
Dr. Rachel Tate uptoTate ( View Tweet)
Ab0577 #ACR22 Sao Paulo Aging & Health (SPAH)
Radius 1/3 BMD enhance fx risk estimates when combined w/ spine (RR 1.4, p=0.03)
For radius+hip or radius+spine/hip, radius DEXA is non-significant - only hip predicted fx
Use radius BMD when hip unattainable- THA/severe OA
@Rheumnow
Eric Dein ericdeinmd ( View Tweet)
Save the date! RheumNow Live is back on 3/18-3/19 in Dallas, Texas.
Register now!
https://t.co/tgce0Mydeh
#RNL23 #ACR22 https://t.co/XI6hcxuNEn
Links:
Dr. John Cush RheumNow ( View Tweet)
Do you know the 3 types of Y. Pestis plague? @AdamJBrownMD reviews the Bubonic, Pneumonic, and Septicemia plagues at #ACR22 @RheumNow. Most recently, there was an outbreak of Pneumonic plague in Madagascar in the 2010s!
Dr. Rachel Tate uptoTate ( View Tweet)
MEFV mutation protected against the plague. Protected against deactivation of inflammasome by yersinia pestis.
@RheumNow #ACR22 #rheuminations https://t.co/OqBay6Svdb
Julian Segan JulianSegan ( View Tweet)