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Evidence-Based Guidelines for EGPA

Jack Cush, MD

Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare form of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, affecting between 10 and 14 cases per million globally. This adult disorder has a mean age at diagnosis of nearly 50 years and affects both sexes equally, presenting with pulmonary symptoms (asthma), eosinophilia and granulomatous or vasculitic involvement of several organs. A multidisciplinary, multinational European group has developed evidence-based, guidelines for the diagnosis and management of EGPA, intended to include recent advances.

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One in Ten is Bad! (5.12.2023)

Jack Cush, MD

This week on the Podcast Dr. Jack Cush reviews the news and journal articles, including the risks of dying, developing RA or autoimmune disease!

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Low Risk of Venous Thromboembolism with IVIG and Dermatomyositis

Jack Cush, MD

A cohort study analyzed the risk of venous thromboembolism (VTE) in dermatomyositis (DM) patients treated with intravenous immunoglobulin (IVIG).

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Romosuzumab and Low Sclerostin Levels Underlie CV Risk

EurekAlert!

New research highlights potential safety concerns around women taking romosozumab, a new anti-osteoporosis drug available on the NHS.

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Pericarditis Management

Eric Dein, MD

On the final day of ACR 2023 State of the Art Conference, Dr. Paul Cremer reviewed pericarditis management. Dr. Cremer, a cardiologist at the Cleveland Clinic Foundation, reviewed the questions patients ask about pericarditis including why the disease develops, will it recur, how is it treated, and what will their treatment duration be. 

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The Match Game (4.14.2023)

Jack Cush, MD

Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com, including Rheumatology success in the NRMP MATCH, Cocaine vasculitis and worrisome safety risks with Biologics and tsDMARDs.

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Low Risk of Venous Thromboembolism with IVIG and Dermatomyositis A cohort study analyzed the risk of venous thromboembolism (VTE) in dermatomyositis (DM) patients treated with intravenous immunoglobulin (IVIG). https://t.co/tYOwsNaiGy https://t.co/Bpfft4J9MB

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Dr. John Cush RheumNow ( View Tweet)
JAKinib safety takeaways - avoid in older population 65 yo, malignancy, CV risk, VTE risk - appropriate in younger pts without VTE/CVD risk factors #RNL2023 @RheumNow https://t.co/mFvvqJ9Jbp https://t.co/A76tR2S1Rb

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Dr. John Cush RheumNow ( View Tweet)
Pericarditis Management Dr. Cremer, a cardiologist at the Cleveland Clinic Foundation, reviewed the questions patients ask about pericarditis including why the disease develops, will it recur, how is it treated, and what will their treatment duration be. https://t.co/EiK3YDzXvT https://t.co/MrS9WeYn0r

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Dr. John Cush RheumNow ( View Tweet)
Metanalysis of Steroids in hosp community-acquired pneumonia (CAP). 18 studies 4661 pts. Corticosteroids reduced mortality in more severe CAP (RR 0.62; 0.45 to 0.85), but not less severe CAP(RR 1.08). Steroids lower need for mech ventilation, ICU https://t.co/dj7zABqQ3r https://t.co/Mb4g7ICdX9

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Dr. John Cush RheumNow ( View Tweet)
Dr. Jeff Sparks talks sex differences and rheumatoid arthritis associated interstitial lung disease. https://t.co/asUrfXw2Y1 https://t.co/oLwi8BvquO

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Dr. John Cush RheumNow ( View Tweet)
Clinical Profile of RA-associated Interstitial Lung Disease A prospective, cross-sectional analysis of patients with rheumatoid arthritis (RA) shows those with interstitial lung disease (ILD) tend to be older, obese and have a smoking history. https://t.co/FazEGcHh5H https://t.co/oh6oIpj21k

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Dr. John Cush RheumNow ( View Tweet)
Japanese cohort study shows Lung cancer is more common in males w/ elder-onset dermatomyositis - risk increased by Smoking, anti-TIF1-γ-Abs and elevated MLR (monocyte to lymphocyte ratio) https://t.co/C7BTAV5gCj https://t.co/YGq6sUbLOh

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Dr. John Cush RheumNow ( View Tweet)
Clinical Profile of RA-associated Interstitial Lung Disease A prospective, cross-sectional analysis of patients with rheumatoid arthritis (RA) shows those with interstitial lung disease (ILD) tend to be older, obese and have a smoking history. https://t.co/Khe9jV1jGa https://t.co/WejiaxolQP

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Dr. John Cush RheumNow ( View Tweet)
Predictors of RA-ILD include smoking, Dz activity, steroid use and obesity. @jeffsparks @UTSW_Rheum https://t.co/VRQc9igHWW
Dr. John Cush RheumNow ( View Tweet)
Methotrexate-induced pneumonitis (0.3% risk) is different than RA-ILD. MTX does not increase odds of RA-ILD. @jeffsparks @UTSW_Rheum https://t.co/JV1CcB0sLP
Dr. John Cush RheumNow ( View Tweet)
Japanese cohort study shows Lung cancer is more common in males w/ elder-onset dermatomyositis - risk increased by Smoking, anti-TIF1-γ-Abs and elevated MLR (monocyte to lymphocyte ratio) https://t.co/LlTkiWp7pb https://t.co/Bu9atnI8je

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Dr. John Cush RheumNow ( View Tweet)
Disease activity increases the risk of future RA-ILD. For every one point increase in DAS28, theres a 35% increase risk of RA-ILD @jeffsparks @UTSW_Rheum https://t.co/P3dNDVanuL
Dr. John Cush RheumNow ( View Tweet)
MUC5B is a common genetic variant (~12%) that is strongly assoc w/ IPF, but also RA-ILD (3.1-4.7 fold risk) @jeffsparks @UTSW_Rheum https://t.co/t1Kgmj8a3x
Dr. John Cush RheumNow ( View Tweet)
Survival in RA-ILD is reduced (data from two different eras) @jeffsparks @UTSW_Rheum https://t.co/7eGgGnEgwW
Dr. John Cush RheumNow ( View Tweet)
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