All News
Ab#0427 #ACR24
HSS: menopause & systemic rheum disease severity
1/3 women report worse disease associated w menopause
Reported more flares, menopausal symptoms
Findings were similar between SLE and RA, but SLE patients were >2x more likely to discuss w their rheum
@RheumNow
Eric Dein ericdeinmd ( View Tweet)
❔Can rheum drugs have beneficial effects on cognition?
💊Possible benefits with MTX and TNFis but certainly an active area of research and more studies needed
#ACR24 @RheumNow https://t.co/lCnIRLwNjK
Mrinalini Dey DrMiniDey ( View Tweet)
#ACR24 abst#0430
- Analyzed 61 SLE pregnancies
- Higher early gestational Mean Arterial Pressure before 20 Weeks linked to increased preeclampsia risk
- MAP trends at 8-10 and 17-19 weeks showed highest predictive accuracy for risk prediction
@RheumNow https://t.co/37mg0WX43v
Bella Mehta bella_mehta ( View Tweet)
Ab#474 #ACR24
Hsieh and @NamrataRheum
Cancer Survival in RA
Unable to do meta-analysis due to lack of data
HR for lung cancer in RA 1.04
No clear evid of increased risk, but more data and studies needed
Great research project by a high school student (!!)
@RheumNow https://t.co/Sfrf2v2UO4
Eric Dein ericdeinmd ( View Tweet)
Global meta-analysis of 61 studies shows TB Preventive treatment (TPT)
- Reduces active TB risk in rheumatic disease patients by 29% (RR: 0.71, CI: 0.57–0.87)
- Best outcomes in high TB-burden countries (RR: 0.51) and with isoniazid for >9 months (RR: 0.52).
- Dual screening… https://t.co/4P1982ngvL
Antoni Chan MD (Prof) synovialjoints ( View Tweet)
Gender based response in Axial SpA. A hot topic at ACR @ACRheum @RheumNow @hac28 @SPARTAN_Updates https://t.co/zbnE6kjQhL
Marina Magrey mmagrey1 ( View Tweet)
Ab#0458 #ACR24
10 year outcomes of 176 patients with seroneg RA
32 pts (18%) had change in dx - SpA (11), seropos RA (6), OA (5), crystal (3), CTD (3), Ifn-related/paraneopl/RS3PE, sarcoid (1)
40 (23%) had drug-free remission
30 (17%) started b/tsDMARD
@RheumNow
Eric Dein ericdeinmd ( View Tweet)
FDA recently approved - fms-like tyrosine kinase 1 (s-Flt1) / placental growth factor (PlGF), for diagnosing preeclampsia.
sFlt1:PlGF≤38 rules out preeclampsia in SLE
sFlt1:PlGF>85 modestly predicts preeclampsia
Proteinuria impacts prediction accuracy #ACR24 abst#0809 @RheumNow
Bella Mehta bella_mehta ( View Tweet)
Langford et al. Abatacept NOT effective in GPA in ABROGATE RCT. 65 patients. Relapse/worsening in 62% vs 68%. No difference in any secondary end-point. @RheumNow #ACR24 Abstr#0823 https://t.co/yRFZ2diJFF https://t.co/LgXkPnDArE
Links:
Richard Conway RichardPAConway ( View Tweet)
Gender differences in axSpA extend to dse activity assessment tools.
PREDICT-SpA:
🔶️BASDAI score performed better in women.
🔶️ ASDAS-CRP homogenous performance on both genders.
Consider BASDAI for assessing dse activity in women?
@RheumNow #ACR24 abs571
@rheumarhyme https://t.co/rKJXn2EPXa
sheila RHEUMarampa ( View Tweet)
👴🏼 Ageing & RMDs at #ACR24
🧠 14 factors associated with dementia
❗️Justin Levenson tells us that if we could address all of these, we could reduce dementia risk by 45%!
@RheumNow https://t.co/SgC5KMohXy
Mrinalini Dey DrMiniDey ( View Tweet)
Nationwide US study
-Prevalence of HLH in SLE: 0.13%
-Higher risk in younger, female, and racial minority patients
- Strong association with high mortality #ACR24 abst#0619 @RheumNow
Bella Mehta bella_mehta ( View Tweet)
Study on #AI-augmented remote care for SLE:
- Combined biometric, self-reported, and NLP-extracted data
- Moderate to strong correlations with physician global assessment
- Potential to improve remote disease management - but now very accurate for now
#ACR24 abst#0635 @RheumNow
Bella Mehta bella_mehta ( View Tweet)
Interim analysis of a Phase 4 study of ARD (RA 25%, SLE 25%) patients shows recombinant herpes zoster vaccine(RZV) good safety profile, with no impact on disease activity (flare rates: 13.6% vs. 12.4%). Immunogenicity: 93% response in ARDs vs. 99% in controls. Rituximab & MMF… https://t.co/U3s48fLduX https://t.co/WTvD5shtXB
Links:
Antoni Chan MD (Prof) synovialjoints ( View Tweet)
Study on socioeconomic factors in SLE hospitalizations - US wide data
- No insurance & non-metro areas linked to shorter LOS, lower costs, higher mortality
- Higher income & age increase charges
- Targeted interventions needed to improve outcomes
#ACR24 abst#0615 @RheumNow
Bella Mehta bella_mehta ( View Tweet)
Can we predict who will develop #RA-#ILD?
Wheeler et al showed a combination of genetic risk score, peripheral protein #biomarkers & clinical risk factors can help identify RA-ILD in RA patients.
Does this bring us closer to #PersonalisedMedicine?
Ab0799 #ACR24 @RheumNow https://t.co/JZkJNGmLM1
Mrinalini Dey DrMiniDey ( View Tweet)
Study on pregnancy outcome disparities in SLE:
- Analyzed 685 women, 1888 pregnancies
- Pre-SLE state linked to fewer live births, higher preeclampsia risk
- Outcomes worse post-SLE diagnosis
#ACR24 abst#0440 @RheumNow https://t.co/NpEYQZ73uo
Links:
Bella Mehta bella_mehta ( View Tweet)
RheumNow’s expanded coverage of the #ACR24 annual meeting is sponsored in part by Bristol Myers Squibb and UCB. All content is chosen by RheumNow & its faculty.
Dr. John Cush RheumNow ( View Tweet)
A systematic review highlights the impact of glucocorticoids (GC) during pregnancy and lactation. Increased risks of preterm birth were noted with GC exposure, advocating for minimized doses and pregnancy-compatible treatments. Encouragingly, low levels of GC found in breast milk… https://t.co/7CnJUBrUDQ https://t.co/ZeGHFHNT13
Links:
Antoni Chan MD (Prof) synovialjoints ( View Tweet)
This abstract reports that patients with ESRD 2/2 to GPA have a higher risk of vertebral fractures compared to individuals with ESRD without GPA. Even low dose steroids (pred 5mg) taken during the first year of HD conferred an increase risk or facture! #ACR24 @RheumNow https://t.co/4xM3XTCHSH
Links:
Gabriela Martinez Zayas, MD MartinezZayasMd ( View Tweet)