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Abatacept Most Effective Early and in Seropositive RA
An open-label, 2 year study evaluated the efficacy and safey (drug retention) of subcutaneous (SC) abatacept (ABA) in active rheumatoid arthritis (RA) and showed superior responses when ABA was given to biologic-naive and seropositive RA patients.
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Watch: Remote Monitoring Technologies in the Management of RA
Dr. Antoni Chan interviews Dr. Johannes Knitza at EULAR 2022
https://t.co/SU9SUScHiS https://t.co/YoxQPZH5eQ
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Dr. John Cush RheumNow ( View Tweet)
Seminal Articles on Stills disease Tues Nite Rheum Journal Club tommorrow
Discussants: Drs. Bella Mehta, Michael Weisman & Jack Cush
7pm EDT (4pmPDT) - The 1st articles on AOSD from Bywaters & Bujak https://t.co/yRgHlmZHhi
https://t.co/ooexkgM6ga
Register: https://t.co/kstge3gAcl https://t.co/XjQJi4FRmt
Dr. John Cush RheumNow ( View Tweet)
Study of 50 #AOSD pts refractory to steroids (n=11), DMARDs (34) & biologics (n 30): given canakinumab 150–300 mg q 4wk (47) or q8wk(3). W/ 27 mos F/U: 78% complete resp w/in 3 mos (20% partial). Steroid sparing in 1/2, Low WBC 6%, 4%SIE https://t.co/QMCLictdrL https://t.co/5hkUOBFDG0
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Dr. John Cush RheumNow ( View Tweet)
Myths & Misconceptions with Febrile Disorders
Dr. Rachel Tate ( @uptotate) weighs on the myths and misconceptions with Still's disease and autoinflammatory disorders.
https://t.co/z0KHbxnLjJ https://t.co/ymsXYDP5Zs
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Dr. John Cush RheumNow ( View Tweet)
QD Clinic - Stills (or Not); A Wife's Letter
A letter from the wife of a hospitalized febrile patient says it all.
But, is this Still's disease or not?
https://t.co/MpPbDU9ZTB https://t.co/BqpusOKKLq
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Dr. John Cush RheumNow ( View Tweet)
213 #SLE pts were screened for Cryoglobulinemia (2013 -2017); CG is frequent in SLE (66%), but mostly asymptomatic. Mean levels 40mg/L (0-228). Cryo Vasculitis in 15% w/ purpura, ulcers, digit ischemia, arthritis, GN (5%) or CNS (19%) https://t.co/R6xUJldgC2 https://t.co/mwsSTI3ztk
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Dr. John Cush RheumNow ( View Tweet)
Can Antimalarials be Withdrawn in Quiescent Lupus?
Antimalaria (AM) therapy is a cornerstone to the management of systemic lupus erythematosus (SLE), yet a recent study suggests that slowly tapering AM yields a lower rate of SLE flares.
https://t.co/dYJy5BOKay https://t.co/pgz694ep2G
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Dr. John Cush RheumNow ( View Tweet)
Still’s Disease FAQs
What is the classic 'triad' of Still's disease? Does it affect males and females equally? What are typical lab findings? Which drugs are effective at treating Still's, and which ones are not? What about complications? Read on...
https://t.co/rsFHNPwo9Y https://t.co/AUP1GpbDaN
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Dr. John Cush RheumNow ( View Tweet)
Ustekinumab (IL-12/23i) phase 2 study was successful in #SLE; but the phase 3 LOTUS study of 512 pts, UST was NOT superior to PBO (SRI-4 44% v 56%) at 1 year. Study was halted for lack of efficacy (but no safety concerns). https://t.co/uMY5uPPabA https://t.co/nG2RO6oEJQ
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Dr. John Cush RheumNow ( View Tweet)
Metanalysis (48 pubs, 145 refract pts) of JAK inhibitors in myositis (DM, JDM) shows significant improvement in skin lesions, muscle weakness, and ILD. https://t.co/cYZ1YEGBOr https://t.co/MDNTSje6a2
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Dr. John Cush RheumNow ( View Tweet)
10% of PsA is PsA Sine Psoriasis - how to differentiate from seroneg RA? PsA sine PsO pts have peripheral arthritis, no skin dz, but may have axial sxs, +Family Hx or nail psoriasis, dactylitis, enthesitis, DIP involvement. https://t.co/2RjGU6Fw2j https://t.co/r7Dsqtksh5
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Dr. John Cush RheumNow ( View Tweet)
Watch: Comanagement of Psoriasis and Psoriatic Arthritis
https://t.co/oo2Vhiwubq https://t.co/iikYssIepQ
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Dr. John Cush RheumNow ( View Tweet)
New download available! We're providing an introduction to Still's Disease.
https://t.co/67XzncaUef https://t.co/gaMNGk0grn
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Dr. John Cush RheumNow ( View Tweet)
MTX + Pegloticase Combo FDA Approved
Horizon has announced that the FDA has approved the expanded labeling of pegloticase (Krystexxa) injection to be co-administered with methotrexate (MTX), to improve response rates in patients with uncontrolled gout.
https://t.co/D71dmMuB9B https://t.co/jonfLqQ0lj
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Dr. John Cush RheumNow ( View Tweet)
Proposed investigations (findings) in the diagnosis of Stills disease: - CRP, ESR, Ferritin (high) - W/U for infection, cancer (negative) - Serologies (negative) - consider Imaging (CXR, CT, US, PET) https://t.co/ByNSq8YACC https://t.co/BdhfRjPA6L
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Dr. John Cush RheumNow ( View Tweet)
New podcast ready for download!
Fever Pitch--Dr. Jack Cush reviews the new studies and drug approvals and new insights into febrile disorders from the past week.
https://t.co/GdntsVNyfS https://t.co/3QdJHNlIKQ
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Dr. John Cush RheumNow ( View Tweet)
Should Physical exercise be recommended in dermatomyositis and polymyositis: a systematic review of 19 studies and 298 patients showed significant improvements in strength & aerobic capacity without change in CK levels or exacerbations https://t.co/G09ITAku2U https://t.co/6Mj0UAgkDE
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Dr. John Cush RheumNow ( View Tweet)
MRP8/14 as a Biomarker in Systemic Juvenile Idiopathic Arthritis
A large cohort study of children with febrile disorders has demonstrated the diagnostic utility of MRP8/14 in diagnosing systemic JIA patients (SJIA) in clinical practice.
https://t.co/Gma3h9Iuqn https://t.co/7GOeES4bbA
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Dr. John Cush RheumNow ( View Tweet)
RTX Induction and Maintenance in Older ANCA–Associated Vasculitis Patients
A cohort study suggests that RTX use among patients 75 years and older with ANCA–associated vasculitis (AAV) is efficacious but also has a high risk of serious adverse events.
https://t.co/HF9hyQcHZV https://t.co/xpDSohFcRK
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Dr. John Cush RheumNow ( View Tweet)