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STING/IFN Activation Promotes ANCA-Associated Vasculitis Progression

d Jack Cush, MD

Research presented in the Journal of Experimental Medicine shows that ANCA-associated vasculitis (AAV) may be propagated by pathogenic mechanisms triggering cGAS/STING/IRF3-dependent IFN-I release.

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Autoimmune Disease Augments Cardiovascular Risk

d Jack Cush, MD

A large UK database study suggests that young adults with autoimmune diseases have an associated increased risk for cardiovascular disease.

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Influenza Vaccination Recommendations

d CDC

The CDC has published an update to the recommendations from the Advisory Committee on Immunization Practices (ACIP) on the use of seasonal influenza vaccines in the United States for the 2022-23 season.

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Influenza Vaccination Recommendations The CDC has published an update to the recommendations from the Advisory Committee on Immunization Practices (ACIP) on the use of seasonal influenza vaccines in the United States for the 2022-23 season. https://t.co/6V21XZUsqX https://t.co/ln9bqta6UT

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Dr. John Cush RheumNow ( View Tweet)
Phase 2 RCTs are evaluating TLR 7 & TLR 8 blockade in SLE - BMS has afimetoran and Merck has enpatoran (both blocking TLR7/8) https://t.co/lSvnAkRvxB https://t.co/i7ZORYyKHP

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Dr. John Cush RheumNow ( View Tweet)
The prospective CARDIA cohort study studied 2110 adults (38 - 50 yrs) for 10+ yrs and showed those taking >7000 steps/day had a 50% to 70% lower risk of mortality (vs those taking <7000 steps/day). https://t.co/lE152z8vTw https://t.co/hjfnCN4bno

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Dr. John Cush RheumNow ( View Tweet)
ALL-HEART study presented in Barcelona at ESC Congress 2022 showed that allopurinol given to 5,721 older adults without gout, failed to reduce # nonfatal myocardial infarction, nonfatal stroke or cardiovascular death in ischaemic heart Dz pts https://t.co/I0dFXQa6Ao https://t.co/8IevQ4uwUY

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Dr. John Cush RheumNow ( View Tweet)
Bidirectional Association Between Depression and Rheumatoid Arthritis A recent meta-analysis suggests a bidirectional association between RA and depression. Finding RA patients with depression yields an 80% increased mortality risk. https://t.co/NUyZ2jAWzE

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Dr. John Cush RheumNow ( View Tweet)

Weight Loss Slows Knee OA Progression Declines in body mass index (BMI) were linked with slower worsening of knee osteoarthritis (OA), according to data from three large longitudinal cohort studies. https://t.co/jJlSTdBdXT https://t.co/9mPJiVT9nE

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Dr. John Cush RheumNow ( View Tweet)
Axial Psoriatic Arthritis and Ankylosing Spondylitis with Psoriasis A cohort analysis from Toronto suggests that axial psoriatic arthritis (PsA) is distinctly different from axial ankylosing spondylitis (AS) with psoriasis. https://t.co/8bAoqp79Mg https://t.co/K2Z1LwPTiS

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Dr. John Cush RheumNow ( View Tweet)

Cochrane review of Stem cell transplantation in systemic sclerosis (3RCTs w/ 125 pts). Non‐myeloablative & myeloablative selective HSCT had moderate evidence for improved survival, skin thickness & function. But these had high Serious AE rates. https://t.co/VKciXY0klN https://t.co/LdMu3RrlZK

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Dr. John Cush RheumNow ( View Tweet)
Learn how to manage lupus: 'The Lupus Encyclopedia: A Comprehensive Guide for Patients and Families' - on #BookBuzz - https://t.co/hvnoFRiabA

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Donald Thomas, MD lupuscyclopedia ( View Tweet)

h/t @alhkim concluded. “Get Evusheld into your patients" - We add give aggressive out pt mgmnt for #Breakthrough @CCalabreseDO @philipcrobinson @drdavidliew B-cell depleting therapies ‘biggest threat’ for reduced SARS-CoV-2 mRNA vaccine response https://t.co/VZRwg0Q6cw

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Leonard Calabrese LCalabreseDO ( View Tweet)

Hyaluronic Acid Knee Injections Equivalent to Placebo In the United States, where over $300 million is spent annually on intraarticular hyaluronic acid injections, yet another study shows such therapy to be no better than placebo. https://t.co/NwJkyECfgM https://t.co/qGLQMWjQG4

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Dr. John Cush RheumNow ( View Tweet)
Charcot (neuropathic) arthropathy of elbow due to Syringomyelia - review of 50 pts. Median age 45 yrs, 2/3 isolated elbow arthritis; other joints: shoulder > wrist > MCPs/IPs. 2/3 had Chiari malformations, sensory/motor deficits, or ulnar neuropathy https://t.co/2hEArpbL8p https://t.co/MK4VTzSSRB

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Dr. John Cush RheumNow ( View Tweet)
Review of VTE risk with JAK inhibitors - Tofacitinib: 10mg or 5 mg bid - PE rates 0.5 & 0.3/100PY; higher w/ risk factors, VTE 0.35/100PY - Baricitinib: IR of DVT/PE was 0.5/100PY - Filgotinib: 200mg VTEs 0.2/100PY Most VTE occured in LT extension of RCT https://t.co/xvf0kQUMel https://t.co/Bj6fmkktP7

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Dr. John Cush RheumNow ( View Tweet)
Dr. Jack Cush delivers this weeks rheumatology "weather report" with the best and least of news and journal articles from the past week on RheumNow. Are you a fan of our podcast? Please rate, like and review us wherever you get your podcast. https://t.co/uj6QF3EqlU https://t.co/lFpoRfkEqU

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Dr. John Cush RheumNow ( View Tweet)
Melatonin Use Growing, Inappropriate & Potentially Unsafe With nearly 1/3 of adults, adolescents and children having sleep difficulties, many resort to using melatonin. But is it effective, safe and warranted? https://t.co/8TA76yAbwr https://t.co/ADYklo0yMz

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Olokizumab, another IL-6 Inhibitor for RA This week's NEJM has published the efficacy results of a large phase 3 trial of olokizumab, a humanized monoclonal antibody that directly targets interleukin-6 (IL-6) in patients with rheumatoid arthritis (RA). https://t.co/VMz8xzffiZ https://t.co/eaA4CUWvrv

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Dr. John Cush RheumNow ( View Tweet)
Hyaluronic Acid Knee Injections Equivalent to Placebo In the United States, where over $300 million is spent annually on intraarticular hyaluronic acid injections, yet another study shows such therapy to be no better than placebo. https://t.co/1pSVr3VI4t https://t.co/DvFN7WQdTp

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Dr. John Cush RheumNow ( View Tweet)
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