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What Worries You, Masters You (7.1.2022)

d Jack Cush, MD

Dr. Jack Cush reviews recent news, regulatory and guideline updates from the past week on RheumNow.com.  Studies on methotrexate use, COVID vaccination, Supplements and vitamins, and arthrocentesis despite anticoagulation are discussed.

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Novel Anti-TNF Shines in Rheumatoid Arthritis Trial

d MedPage Today

A new way of inhibiting tumor necrosis factor (TNF) for treating rheumatoid arthritis showed strong results in a phase II/III clinical trial, researchers said.

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Placebo Works Best in Combination

d Jack Cush, MD

Analysis of two large clinical trial datasets shows that placebo response rates in randomised controlled trials (RCTs) of patients with rheumatoid arthritis are better when the patient continued background methotrexate (MTX). 

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GRAPPA,PsA,guideline

New Updated GRAPPA Psoriatic Arthritis Recommendations

d Jack Cush, MD

The GRAPPA (Group for Research and Assessment of Psoriasis and Psoriatic Arthritis) treatment recommendations have been updated and the 2021 evidence-based guidance is rich in treatment recommendations based on the key disease "domains" - peripheral arthritis, axial disease, enthesitis, dactylitis, skin and nail psoriasis; with new PsA related domains uveitis and inflammatory bowel disease.

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Idiopathic inflammatory myopathies, Camille Rasmussen #BJHM #MedEd #FOAMed #Medtwitter #Myopathy #rheumtwitter #MedStudentTwitter https://t.co/dsqwHIAqnX
Brown Journal of Hospital Medicine BrownJHM ( View Tweet)
Are you an Expert in Still's disease, Periodic Fevers, FMF or Autoinflammatory Dz? We will add you to our expert referral listing. DM me to get on the list! https://t.co/hCkC1Yu9Nh
Dr. John Cush RheumNow ( View Tweet)
Novel Anti-TNF Shines in Rheumatoid Arthritis Trial A new way of inhibiting tumor necrosis factor (TNF) for treating rheumatoid arthritis showed strong results in a phase II/III clinical trial, researchers said. https://t.co/fTmWeIrVD5 https://t.co/LPk2Ok2gac

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Dr. John Cush RheumNow ( View Tweet)
Placebo Works Best in Combination Analysis of two large clinical trial datasets shows that placebo response rates in randomised controlled trials (RCTs) of patients with rheumatoid arthritis are better when the patient continued background MTX. https://t.co/JmNGRQWv6L https://t.co/77LdcTwCvl

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Dr. John Cush RheumNow ( View Tweet)
New Updated GRAPPA Psoriatic Arthritis Recommendations The GRAPPA treatment recommendations have been updated and the 2021 evidence-based guidance is rich in treatment recommendations based on the key disease "domains." https://t.co/PkDofio1eh https://t.co/kp6UEgwonV

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Video: Post Hoc Analysis of the ORAL Surveillance Study https://t.co/PVzfYlzdQa https://t.co/0RpA3CfTEE

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Gabapentin Implicated in Overdose Deaths Recent FDA and MMWR warnings suggest that gabapentin was present in almost 10% of US overdose deaths between 2019 & 2020. The report also stated that gabapentin was the cause of the death in half of these cases. https://t.co/ilNAd7ifdZ https://t.co/5GIcySXSDZ

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Dr. John Cush RheumNow ( View Tweet)
No science to F/U visit scheduling. Study of 114 outpt SpA visits, 34% considered unnecessary (fewer Rx change 15 v 52%) & clinical actions (23 v 63%) visits) vs. "necessary" visits (predict by ASDAS ≥2.1 & PtGA ≥3 >80%). Remote monitoring role? https://t.co/J8TIQRb0LG https://t.co/TCSN0NaeC8

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Video: Cancer after Biologic Use in Patients with a History of Prior Malignancy https://t.co/jr37Ti7c9J https://t.co/iYCXzhXD44

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Dr. John Cush RheumNow ( View Tweet)
Study of contoured foot orthoses vs sham shoe insoles in 1st MTP #OA pain: 87 pts completed 12 wk trial that showed no differences in 1st MTP walking pain or other 2nd outcomes. Hard orthoses are no more effective than flat sham insoles https://t.co/XAFWwpSjHm https://t.co/g5J9TbG2pQ

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Dr. John Cush RheumNow ( View Tweet)
Study of IV CTX (n 13) vs mepolizumab (n 7)(MPZ; IL-5 inhib) in severe eosinophilic granulomatosis polyangiitis. BVAS & EOS# equal at mo 1 & 6, but MPZ had better retention(61 vs 5%) & less AEs (29% vs 54%) https://t.co/YqfOu0X3jY https://t.co/fPBzogQFal

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Dr. John Cush RheumNow ( View Tweet)
Full read review of Inclusion body myositis: an untreatable, slowly progressive muscle disorder seen w/ aging; distinctive pattern of weakness involving the quadriceps and finger flexor muscles, w/ certain genetic predispositions https://t.co/BxwyTacnZF https://t.co/c4wDkX6Yi9

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Dr. John Cush RheumNow ( View Tweet)
Danish IBD+RA registry study of TNFi induced Psoriasis in 109k non-PSO pts (20K on TNFi). PSO risk equal betw non-TNFi & conventional Rx. Compared to latter, TNFi increased nonpustular PSO (HR 2.12; NNH 342 PY) & pustular PSO (HR 6.5; NNH 909 PY) https://t.co/5l3qlyYoFy https://t.co/Ce4RmnfHOm

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Dr. John Cush RheumNow ( View Tweet)
Are You Wasting Money on Supplements or Vitamins? https://t.co/svXLP3wGlB https://t.co/kz2SFHndrb

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Dr. John Cush RheumNow ( View Tweet)
JAMA Clinical Review 15 min podcast on treatment of carpal tunnel syndrome and trigger finger and common hand problems in clinical practice; featuring Drs. Mary M. McDermott, and Kelly Currie https://t.co/jkk3LEtZjB https://t.co/YIW1Y0leXg

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Dr. John Cush RheumNow ( View Tweet)
The EMA's CHMP has positively recommended upadacitinib for use in Non-radiographic axial spondyloarthritis (nr-axSpA) based on Phase 3 SELECT-AXIS 2 study showing superior ASAS40 responses at week 14 https://t.co/54btcIz2J1 https://t.co/gDCPx1DATM

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Dr. John Cush RheumNow ( View Tweet)

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