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virus,injection,COVID,vaccine

Two Week Methotrexate Hold with COVID-19 Vaccination

d Jack Cush, MD

A cohort study of rheumatoid arthritis (RA) patients evaluated immunogenicity of COVID vaccination with and without holding methotrexate (MTX) for and 2-weeks and showed better immunogenicity, but more RA flares with the second MTX withdrawal. 

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Podcast on Podcasting (6.24.22)

d Jack Cush, MD

A tutorial on podcasting - what works and what does not, 7 keys to podcast success, who and what is it for, and more!

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hudsonpsoriasis.jpg

Bimekizumab Safety in Psoriasis Patients

d Jack Cush, MD

A pooled analyses of data from eight, phase 2 and 3 randomized clinical trials shows bimekizumab, a dual IL-17A/F inhibitor, to be effective in plaque psoriasis and was well tolerated aside from an increased incidence of mild to moderate oral candidiasis. 

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Simultaneous Versus Staged Knee Arthoplasty?

d Jack Cush, MD

Aside from cost, there are significant concerns regarding efficacy and safety outcomes and recovery time. These issues are compounded with the need for bilateral TKR, wherein the patient and surgeon need to decide whether to have both TKRs done simultaneously or staged (single TKR one after another with a recovery period in between).

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Modest Benefits of Diet on Arthritis A EULAR taskforce reviewed the literature on the effects of diet and lifestyle behaviors in RMDs, and found little evidence suggesting dietary factors can substantially affect the outcomes in people with RMDs. https://t.co/D31l7dlq9v https://t.co/Kt80Yp74ro

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Dr. John Cush RheumNow ( View Tweet)
#Leadership = serving your team, being the fall guy, getting group through crazy unnecessary beaurocracy, and loving something about each member of the group. Having their back, sacrificing for them. I can only strive to lead....

Janet Pope Janetbirdope ( View Tweet)

Treatment of pyoderma gangrenosum is clinically empiric. Full read ref w/ Graded Rx Recommendations: - 1st line: Steriods or Cyclosporin - Consider biologics: TNFi, IL-1, IL-12/23, IL-17, IL-23 - Others: MTX, MMF, AZA, Dap, colchic, thalidomide, IVIG https://t.co/uMJyfFzsRB https://t.co/vw4VqbjZWh

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Dr. John Cush RheumNow ( View Tweet)
Multinational recs. on Rx of JIA assoc. Uveitis: - Topical steroids are 1st line Rx - Systemic Rx if above fails or w/ poor prognosis or persistence - Options MTX, MMF then Humira EOW, then weekly ADA - Consider non-ETN TNFi's, then TCZ, ABA, JAKi or RTX https://t.co/ZfVeWf5sVg https://t.co/yu3to0LdEd

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Dr. John Cush RheumNow ( View Tweet)
Podcast on Podcasting A tutorial on podcasting - what works and what does not. https://t.co/QINseXd6Z2 https://t.co/OFuVacgcfq

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Dr. John Cush RheumNow ( View Tweet)
Environmental articulate matter (PM2.5) levels can increase the odds of a systemic autoimmune rheumatic disease onset (OR 1.12; 1.08–1.15), , w/ no effect of ozone. Results not changed by controlling for smoking. https://t.co/7BGBh9h0lf https://t.co/LcUo4Lxzgx

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Dr. John Cush RheumNow ( View Tweet)
Axial PsA: Is it for Real? Dr. Janet Pope ( @Janetbirdope) presenting from EULAR 2022. https://t.co/0smaACel5k https://t.co/UJ3hi3rJlY

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Dr. John Cush RheumNow ( View Tweet)
Lupus Research Alliance’s has awarded the Lupus Insight Prize to Akiko Iwasaki, PhD (professor at Yale School of Medicine) for her research on the pathogenic role of retroviruses in lupus published in Journal of Experimental Medicine https://t.co/xmQjFLk63K https://t.co/68Ezlfk00j

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Dr. John Cush RheumNow ( View Tweet)
Lower Fx risk in PsA Rx w/ biologics? Review of 100 RCTs, 51,413 Pso & PsA pts; pts on bDMARDs had signif lower risk of major OP Fx (OR 0.34), hip Fx (OR 0.22) & OP non-vertebral Fx (OR 0.26). Fx risk not changed in RA, axSpA, SLE, IBD pts on biologics https://t.co/Acv1q1K5A9 https://t.co/dAaq2EsTDK

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Dr. John Cush RheumNow ( View Tweet)
RWE & Registries in Psoriatic Arthritis Dr. Alexis Ogdie presents RWE & Registries in Psoriatic Arthritis at the 2022 RheumNow Live meeting. https://t.co/zYcDrhgbNr https://t.co/s4Hv3ub9Av

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Dr. John Cush RheumNow ( View Tweet)
Metanalysis of 7 studies shows that oral anticoagulants need not be discontinued for joint injections or aspiration. Only pts w/ hemorrhage after 5427 procedures, over 32-yrs. INR values of 3 bleeding cases was 1.9, 2.3, and 3.4. https://t.co/l130TsksVi https://t.co/OD7SSBuAS0

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Dr. John Cush RheumNow ( View Tweet)
COVID-19 Death is Dependent on Age and Type I IFN Autoantibodies https://t.co/WrWujgHoA4 https://t.co/NTwUeXHYKr

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Dr. John Cush RheumNow ( View Tweet)
506 ANCA-Assoc vasculitis pt study - 72% were MPO-ANCA+ & 68% w/ renal Dz, & Rx w/ RTX (59%) or CTX (33%) - 16% died, 10% ESRD & 13% relapsed. ANCA negativity had less relapse (HR 0.55; 0.38, 0.81) but not less ESRD or death @ 5 yrs https://t.co/iCrxH9UArl https://t.co/6s3TmQqxVQ

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Dr. John Cush RheumNow ( View Tweet)
Japanese claims data study looked at hospitalizable infections (SIE) in RA pts based on age: young (16-64 y), old (65-74y), very old (>75y) and showed age related increase in SIE - 3.2, 5.0, and 10.1 SIE/100PY, respectively. (#s unaffected by biologic use)https://t.co/deaGy3g0Ai https://t.co/2A5mB8n4FK

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Dr. John Cush RheumNow ( View Tweet)
Does Sunlight Trigger Lupus? Whether exposure to ultraviolet (UV) radiation from the sun can cause new-onset systemic lupus erythematosus (SLE) wasn't settled by data from a large, long-running epidemiologic study, but the trends indicated that it could. https://t.co/IYhPv0dB9Z https://t.co/cza7qGSCbu

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Dr. John Cush RheumNow ( View Tweet)
Military biobank of serial serum samples was used to identify biomarkers of imminent RA (vs reactive arthritis or healthy controls). Soluble programmed cell death receptor-1 (sPD-1) best predicted seropos. RA w/in 6mos of Dx. Specif >89%; sensitivity 48% https://t.co/djOGhLeCIi https://t.co/DzKqwteQku

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Dr. John Cush RheumNow ( View Tweet)

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