ACR 2023 is back in San Diego for its annual convergence of thousands of rheumatologists to partake, discover and learn from thousands of abstracts and hundreds of sessions and presentations. It was a big return for the Poster Hall with rows and rows of research, friends, fellows and poster tours. Below are a few of my favorite presentations from the posters, Plenary and oral sessions on day one.
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Whether it’s RA, SLE or Sjogren’s, the increased prevalence of females affected by auto-immune diseases is well established, yet not fully understood. Often, I have heard that sexual hormones are responsible for every aspect of it. Two abstracts presented this year question this paradigm.
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The RheumNow faculty reporters have been scouring the meeting for what they believe to be the best presentations from the first day at ACR 2023 in San Diego. From hundreds of online presentations, the poster floor and the plenary podium, here are some of the best abstracts from Sunday Nov. 12th. You can spot these on Twitter by looking for the (#ACRbest) hashtag.
Obintuzumab in Lupus Nephritis
Researchers found that treatment with obinutuzumab was superior to placebo for preserving kidney function and preventing flares in patients with lupus nephritis.
https://t.co/Sbh6k6XKjz https://t.co/aDbLUh7WtM
Meral K. El Ramahi, MD
Tweet
Patient perspective: PP09 at #ACR23
"Mindfulness helps me experience less suffering over pain" in patient with PsA + fibromyalgia.
⭐️Consider recommending mindfulness training such as mindfulness based stress reduction
@RheumNow https://t.co/DHwduvTPZL
Meral K. El Ramahi, MD
Tweet
ABS0122 at #ACR23
⭐️Risk of acute MI, stroke & death signif ⬆️ among RA/SLE pts w/ depress, anxiety, &/or PTSD vs w/o both RA/SLE
➡️U.S. pts: 3825 RA, 1862 SLE --> 1790 w/ above mental health dz, no prior CVD
➡️HR 1.28 after adjusting for🚬, obesity, & comorbidities
@RheumNow https://t.co/sXMFtaKmYB
Meral K. El Ramahi, MD
Tweet
ABS0155 @ #ACR23
Economic impact of switching from SQ MTX (Rasuvo) from oral MTX in U.S. RA pts?'
➡️ Rasuvo associated with significantly higher all cause total expenditure $4704 predominantly due to higher costs associated tin all cause pharmacy utilization $4,223!
@Rheumnow https://t.co/ry8XxjvHRg
Meral K. El Ramahi, MD
Tweet
ABS0164 @ #ACR23
Is a virtual MSK test consistent & comparable to in-person assessments w/ regard to dz activity in f/u of RA pts?
YES!
Some variability in # of swollen joints but approach shown below had good reliability & acceptable lvl of agreement
@RheumNow #ACRBEST https://t.co/yxpPb2Br4n
Meral K. El Ramahi, MD
Tweet
TM01 @ #ACR23: Daunting Case of Diarrhea
65 yo F w/ sero+RA + 2ndary SjS p/w 4 wks diarrhea
-CT a/p: thickening of cecum, ascending colon
-Colonoscopy path: ischemia
-R colectomy: enterocoelic lymphocytic phlebitis, no underlying vasculitis. Dx: IgG4-RD, serum IgG4⬆️
@RheumNow https://t.co/jQ57U5EjPo
Meral K. El Ramahi, MD
Tweet
TM02 @ #ACR23:
19yo F w/ SLE p/w 1w DOE
PMHx: SLE (malar, LN, AIHA, ITP) on HCQ x 10yrs
Dx?
HCQ-induced CM (curvilinear bodies, vacuolar degen)
⭐️RF for HCQ-induced cardio-toxicity:
- older age, F
- HCQ > 10 yrs, ⬆️ daily dose
- hx of cardiac dz
- renal insuffic
@RheumNow https://t.co/GgzB2Chgra
Meral K. El Ramahi, MD
Tweet
TM03 @ #ACR23
40 yo healthy F p/w swelling, red papule, hyperpigmentation, firmness, & tightness on R semi-body
Dx? Unilateral generalized morphea (UGM)
No guidelines for tx of morphea or UGM
This case report showed success w/ IVMP + PO Pred & MTX & TCZ for maint
@RheumNow https://t.co/iOVqhwmCVz
Dr. Antoni Chan
Tweet
Come and visit poster 1410 in the poster hall today. I will be sharing our work using the ASAS @Official_ASAS referral guidelines for earlier diagnosis of Axial Spondyloarthritis, Chan A et al Abst#1410 #ACR23 @RheumNow https://t.co/jB3FHPSBqs
CAR-T cell Rx show promise for drug-free remission in refractory #SLE without affecting vaccination response despite depleting CD19+ plasmablasts https://t.co/WXa4ADfcF6 abst#0606 @RheumNow #ACR23 https://t.co/ga4DCcbMhD
Promising! #Cenerimod is a selective S1P1 Receptor modulator has potential in SLE through modulating lymphocyte trafficking, inflammation, and autoantigen transport. Phase 2 showed reduced T/B lymphocytes, autoAb levels, and secretions of IFN-a. #abstr0584 @rheumNow #ACR23
Nouf Al hemmadi
Tweet
Great work by @Yuz6Yusof
ANA positive and diagnosis , prediction tool to rule out/ in autoimmune pathology.
1-High interferon score.
2-FH autoimmune disease.
3- More criteria.
?Monogenic error of immune system , ?genome assessment .
@RheumNow , Daily recap
I vote for the ❤️
Several abstracts evaluated cardiovascular event prevalence and screening tools using ECHO, carotid ultrasound as current CV risk calculators are inadequate when assessing SLE CV risk. See my blog - just published @RheumNow
https://t.co/XLc0YHtJ0B https://t.co/oF0fXBRM6O
Nouf Al hemmadi
Tweet
1-Can we prevent RA ? Vagotomy?
2-CV events in auto immune rheumatic disease pregnancies.
3-CVS vasculitis , challenges and role of Brain biopsy
And others……..
https://t.co/BX8bDSX1M3
@RheumNow , daily recap
#ACR23
Nouf Al hemmadi
Tweet
Sunday recap @RheumNow
Very interesting abstracts:
https://t.co/BX8bDSX1M3
1- Fecal calprotectin in SpA population.
2-SLE; high or low steroids? Rapid or slow taper?
3-Molecular biomarkers for PAH in SLE.
4-Repeating imaging in ? Chronic back pain?
And others …….


